In a cross-sectional study of individuals with type 1 diabetes mellitus, those who were designated to be slow disease progressors had an increased proportion of autoreactive, islet-specific CD8+ T cells expressing an ‘exhausted’ phenotype. By contrast, rapid disease progressors had increased numbers of islet-specific CD8+ T cells with a transitional memory phenotype.
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Acknowledgements
F.S.W. acknowledges the support of a grant from Diabetes UK (18/0005805), and L.W. acknowledges the support of Diabetes Research Connection (19–004803) and Yale Diabetes Research Center (P30-DK-45735).
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Wong, F.S., Wen, L. A predictive CD8+ T cell phenotype for T1DM progression. Nat Rev Endocrinol 16, 198–199 (2020). https://doi.org/10.1038/s41574-020-0330-3
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DOI: https://doi.org/10.1038/s41574-020-0330-3
