Abstract
Purpose
The purpose of this study was to establish a mouse model of proximal fibular osteotomy (PFO), and to determine if PFO could delay degeneration of the medial compartment of the knee joint in a mouse model.
Methods
An animal model of destabilization of the medial meniscus (DMM) was used to induce post-traumatic knee osteoarthritis (OA). PFO was performed to examine the effectiveness of PFO on protection against medial compartment knee OA. Micro-CT was used to observe osteosclerosis development in the subchondral bone, and Safranin O-fast green staining was used to evaluate the progression of articular cartilage destruction. The condylar-plateau angle (CPA) and anatomical femorotibial angle (aFTA) were measured to determine whether knee alignment was changed after PFO.
Results
PFO treatment could decrease osteophyte formation and osteosclerosis development in the subchondral bone, as observed by micro-CT. The value of the ratio of trabecular bone volume to total volume (BV/TV) of DMM+PFO group was lower than that of DMM group. PFO also inhibited the progression of articular cartilage destruction. DMM + PFO group displayed decreased maximal and summed OA scores, as compared with DMM group. Moreover, the change of knee alignment was reduced by PFO, which might be the mechanism of PFO alleviating medial compartment knee OA.
Conclusion
Our results indicated that PFO could alleviate medial compartment knee OA in a mouse model.
Similar content being viewed by others
References
Hernborg JS, Nilsson BE (1977) The natural course of untreated osteoarthritis of the knee. Clin Orthop Relat Res 123:130–137
Mistry DA, Chandratreya A, Lee PYF (2018) An update on unloading knee braces in the treatment of unicompartmental knee osteoarthritis from the last 10 years: a literature review. Surgery journal 4(3):e110–e118. https://doi.org/10.1055/s-0038-1661382
Wang J, Lv HZ, Chen W et al (2019) Anatomical adaptation of fibula and its mechanism of proximal partial fibulectomy associated with medial compartment knee osteoarthritis. Orthop Surg 11(2):204–211. https://doi.org/10.1111/os.12437
Wu LD, Hahne HJ, Hassenpflug J (2004) A long-term follow-up study of high tibial osteotomy in medial compartment osteoarthrosis. Zhonghua Wai Ke Za Zhi 42(8):474–477
Sprenger TR, Doerzbacher JF (2003) Tibial osteotomy for the treatment of varus gonarthrosis. Survival and failure analysis to twenty-two years. J Bone Joint Surg Am 85(3):469–474
Lei YT, Xie JW, Huang Q et al (2019) The antifibrinolytic and anti-inflammatory effects of a high initial-dose tranexamic acid in total knee arthroplasty: a randomized controlled trial. Int Orthop. https://doi.org/10.1007/s00264-019-04469-w
Popescu R, Haritinian EG, Cristea S (2020) Methods of intra- and post-operative determination of the position of the tibial component during total knee replacement. Int Orthop 44(1):119–128. https://doi.org/10.1007/s00264-019-04424-9
Tapper V, Toom A, Pesola M et al (2020) Knee joint replacement as primary treatment for proximal tibial fractures: analysis of clinical results of twenty-two patients with mean follow-up of nineteen months. Int Orthop 44(1):85–93. https://doi.org/10.1007/s00264-019-04415-w
Yang ZY, Chen W, Li CX et al (2015) Medial compartment decompression by fibular osteotomy to treat medial compartment knee osteoarthritis: a pilot study. Orthopedics 38(12):e1110–e1114. https://doi.org/10.3928/01477447-20151120-08
Wang X, Wei L, Lv Z et al (2017) Proximal fibular osteotomy: a new surgery for pain relief and improvement of joint function in patients with knee osteoarthritis. J Int Med Res 45(1):282–289. https://doi.org/10.1177/0300060516676630
Utomo DN, Mahyudin F, Wijaya AM et al (2018) Proximal fibula osteotomy as an alternative to TKA and HTO in late-stage varus type of knee osteoarthritis. J Orthop 15(3):858–861. https://doi.org/10.1016/j.jor.2018.08.014
Baldini T, Roberts J, Hao J et al (2018) Medial compartment decompression by proximal fibular osteotomy: a biomechanical cadaver study. Orthopedics 41(4):e496–e501. https://doi.org/10.3928/01477447-20180424-05
Qin D, Chen W, Wang J et al (2018) Mechanism and influencing factors of proximal fibular osteotomy for treatment of medial compartment knee osteoarthritis: a prospective study. J Int Med Res 46(8):3114–3123. https://doi.org/10.1177/0300060518772715
Kamekura S, Hoshi K, Shimoaka T et al (2005) Osteoarthritis development in novel experimental mouse models induced by knee joint instability. Osteoarthr Cartil 13(7):632–641. https://doi.org/10.1016/j.joca.2005.03.004
Glasson SS, Chambers MG, Van Den Berg WB et al (2010) The OARSI histopathology initiative-recommendations for histological assessments of osteoarthritis in the mouse. Osteoarthr Cartil 18(Suppl 3):S17–S23. https://doi.org/10.1016/j.joca.2010.05.025
Harvey WF, Niu J, Zhang Y et al (2008) Knee alignment differences between Chinese and Caucasian subjects without osteoarthritis. Ann Rheum Dis 67(11):1524–1528. https://doi.org/10.1136/ard.2007.074294
Hashimoto S, Rai MF, Janiszak KL et al (2012) Cartilage and bone changes during development of post-traumatic osteoarthritis in selected LGXSM recombinant inbred mice. Osteoarthr Cartil 20(6):562–571. https://doi.org/10.1016/j.joca.2012.01.022
Carlson CS, Loeser RF, Purser CB et al (1996) Osteoarthritis in cynomolgus macaques III: effects of age, gender, and subchondral bone thickness on the severity of disease. J Bone Miner Res 11(9):1209–1217. https://doi.org/10.1002/jbmr.5650110904
Burr DB, Gallant MA (2012) Bone remodelling in osteoarthritis. Nat Rev Rheumatol 8(11):665–673. https://doi.org/10.1038/nrrheum.2012.130
Fang H, Huang L, Welch I et al (2018) Early changes of articular cartilage and subchondral bone in the DMM mouse model of osteoarthritis. Sci Rep 8(1):2855. https://doi.org/10.1038/s41598-018-21184-5
Vos T, Flaxman AD, Naghavi M et al (2012) Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380(9859):2163–2196. https://doi.org/10.1016/S0140-6736(12)61729-2
Arshi A, Leong NL, D'Oro A et al (2017) Outpatient total knee arthroplasty is associated with higher risk of perioperative complications. J Bone Joint Surg Am 99(23):1978–1986. https://doi.org/10.2106/JBJS.16.01332
Bass AR, McHugh K, Fields K et al (2016) Higher total knee arthroplasty revision rates among United States blacks than whites: a systematic literature review and meta-analysis. J Bone Joint Surg Am 98(24):2103–2108. https://doi.org/10.2106/JBJS.15.00976
Ghinelli D, Parma A, Baldassarri M et al (2016) High tibial osteotomy for the treatment of medial osteoarthritis of the knee with new iBalance system: 2 years of follow-up. Eur J Orthop Surg Traumatol 26(5):523–535. https://doi.org/10.1007/s00590-016-1768-9
Hernigou P, Medevielle D, Debeyre J et al (1987) Proximal tibial osteotomy for osteoarthritis with varus deformity. A ten to thirteen-year follow-up study. J Bone Joint Surg Am 69(3):332–354
Weidenhielm L, Svensson OK, Brostrom Lk LA (1995) Surgical correction of leg alignment in unilateral knee osteoarthrosis reduces the load on the hip and knee joint bilaterally. Clin Biomech 10(4):217–221
Dong T, Chen W, Zhang F et al (2016) Radiographic measures of settlement phenomenon in patients with medial compartment knee osteoarthritis. Clin Rheumatol 35(6):1573–1578. https://doi.org/10.1007/s10067-015-3146-0
Wang J, Chen W, Hou ZY et al (2019) Law of dynamic deformation of bone. Chin Med J 132(21):2636–2637. https://doi.org/10.1097/CM9.0000000000000483
Funding
The study was funded by major projects of the National Natural Science Foundation of China (91949203), 3-3-3 talent project for high-level talents of Hebei Province (A2017005073), Innovation funding projects for doctoral candidates in Hebei province (CXZZBS2019111).
Author information
Authors and Affiliations
Contributions
Tian-Rui Wang, Hong-De Wang, and Ying-Ze Zhang contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Tian-Rui Wang, Hong-De Wang, Wei Chen, Teng-Bo Yu, and Yan-Qin. The first draft of the manuscript was written by Tian-Rui Wang and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Ethical approval
All procedures performed in studies involving animals were in accordance with the ethical standards of Hebei Medical University.
Additional information
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Wang, TR., Wang, HD., Chen, W. et al. Proximal fibular osteotomy alleviates medial compartment knee osteoarthritis in a mouse model. International Orthopaedics (SICOT) 44, 1107–1113 (2020). https://doi.org/10.1007/s00264-020-04497-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00264-020-04497-x