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Proximal fibular osteotomy alleviates medial compartment knee osteoarthritis in a mouse model

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Abstract

Purpose

The purpose of this study was to establish a mouse model of proximal fibular osteotomy (PFO), and to determine if PFO could delay degeneration of the medial compartment of the knee joint in a mouse model.

Methods

An animal model of destabilization of the medial meniscus (DMM) was used to induce post-traumatic knee osteoarthritis (OA). PFO was performed to examine the effectiveness of PFO on protection against medial compartment knee OA. Micro-CT was used to observe osteosclerosis development in the subchondral bone, and Safranin O-fast green staining was used to evaluate the progression of articular cartilage destruction. The condylar-plateau angle (CPA) and anatomical femorotibial angle (aFTA) were measured to determine whether knee alignment was changed after PFO.

Results

PFO treatment could decrease osteophyte formation and osteosclerosis development in the subchondral bone, as observed by micro-CT. The value of the ratio of trabecular bone volume to total volume (BV/TV) of DMM+PFO group was lower than that of DMM group. PFO also inhibited the progression of articular cartilage destruction. DMM + PFO group displayed decreased maximal and summed OA scores, as compared with DMM group. Moreover, the change of knee alignment was reduced by PFO, which might be the mechanism of PFO alleviating medial compartment knee OA.

Conclusion

Our results indicated that PFO could alleviate medial compartment knee OA in a mouse model.

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Funding

The study was funded by major projects of the National Natural Science Foundation of China (91949203), 3-3-3 talent project for high-level talents of Hebei Province (A2017005073), Innovation funding projects for doctoral candidates in Hebei province (CXZZBS2019111).

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Author notes

  1. Tian-Rui Wang, Hong-De Wang and Wei Chen contributed equally to this work.

Authors and Affiliations

  1. Department of Orthopedic Surgery, The Third Hospital of Hebei Medical University, No. 139 Ziqiang Road, Qiaoxi District, Shijiazhuang, 050051, Hebei, People’s Republic of China

    Tian-Rui Wang, Hong-De Wang, Wei Chen & Ying-Ze Zhang

  2. Key Laboratory of Biomechanics of Hebei Province, The Third Hospital of Hebei Medical University, Shijiazhuang, 050051, Hebei, People’s Republic of China

    Tian-Rui Wang, Hong-De Wang, Wei Chen & Ying-Ze Zhang

  3. Department of Orthopedic Surgery, Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong, People’s Republic of China

    Teng-Bo Yu

  4. Department of Biochemistry and Molecular Biology, Hebei Medical university, Shijiazhuang, 050017, People’s Republic of China

    Yan Qin

  5. Chinese Academy of Engineering, Beijing, People’s Republic of China

    Ying-Ze Zhang

Authors
  1. Tian-Rui Wang
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  2. Hong-De Wang
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  3. Wei Chen
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  4. Teng-Bo Yu
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  5. Yan Qin
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Contributions

Tian-Rui Wang, Hong-De Wang, and Ying-Ze Zhang contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Tian-Rui Wang, Hong-De Wang, Wei Chen, Teng-Bo Yu, and Yan-Qin. The first draft of the manuscript was written by Tian-Rui Wang and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Ying-Ze Zhang.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving animals were in accordance with the ethical standards of Hebei Medical University.

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Wang, TR., Wang, HD., Chen, W. et al. Proximal fibular osteotomy alleviates medial compartment knee osteoarthritis in a mouse model. International Orthopaedics (SICOT) 44, 1107–1113 (2020). https://doi.org/10.1007/s00264-020-04497-x

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  • DOI: https://doi.org/10.1007/s00264-020-04497-x

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