Issue 7, 2020
From the journal:

Analyst

Silicotungstic acid as a highly efficient coreactant for luminol chemiluminescence for sensitive detection of uric acid†

Islam M. Mostafa,abc   Mohamed Ibrahim Halawa,ad   Yequan Chen,a   Abubakar Abdussalam,ab   Yiran Guan*ab  and  Guobao Xu ORCID logo *ab  

* Corresponding authors

a State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, PR China
E-mail: guobaoxu@ciac.ac.cn, guanyr@ciac.ac.cn

b University of Science and Technology of China, Hefei, PR China

c Department of Analytical Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt

d Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura, Egypt

Abstract

Herein, we report luminol–silicotungstic acid (STA) chemiluminescence (CL) for the first time. The luminol–STA system resulted in remarkable CL enhancement (65 times) compared with the known classical luminol–H2O2 system because of the generation of the strong oxidizing agent tungsten trioxide from STA. Based on the quenching effect of uric acid, the new CL system is applied for the sensitive and selective assay of uric acid in its pure state (LOD 0.75 nM) and in real human urine with excellent recoveries in the range of 99.6–102.3%. Furthermore, this system permits the efficient detection of STA (LOD, 0.24 μM).

Graphical abstract: Silicotungstic acid as a highly efficient coreactant for luminol chemiluminescence for sensitive detection of uric acid

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Article information

DOI
https://doi.org/10.1039/C9AN02600B
Article type
Paper
Submitted
23 Dec 2019
Accepted
09 Feb 2020
First published
10 Feb 2020

Analyst, 2020,145, 2709-2715

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Silicotungstic acid as a highly efficient coreactant for luminol chemiluminescence for sensitive detection of uric acid

I. M. Mostafa, M. I. Halawa, Y. Chen, A. Abdussalam, Y. Guan and G. Xu, Analyst, 2020, 145, 2709 DOI: 10.1039/C9AN02600B

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