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Modification of biologically active amides and amines with fluorine-containing heterocycles

14.* Modification of the drug “riluzole” with an alkyne-azide “click”-reaction with pharmacologically active fragments

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Russian Chemical Bulletin Aims and scope

Abstract

A synthetic approach to the modification of the drug “riluzole” with pharmacologically active fragments such as carbazole, tetrahydrocarbazole, phenothiazine, and aminothiophene, based on the copper-catalyzed alkyne-azide 1,3-dipolar cycloaddition of azide-containing pharmacophores with “riluzole” decorated with 5-trifluoromethylhydantoin, has been suggested.

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Authors and Affiliations

  1. Institute of Physiologically Active Substances, Russian Academy of Sciences, 1 Sevemyiproezd, 142432, Chernogolovka, Moscow Region, Russian Federation

    V. B. Sokolov, A. Yu. Aksinenko, T. V. Goreva, T. A. Epishina & S. O. Bachurin

Authors
  1. V. B. Sokolov
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  2. A. Yu. Aksinenko
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  3. T. V. Goreva
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  4. T. A. Epishina
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  5. S. O. Bachurin
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Corresponding author

Correspondence to A. Yu. Aksinenko.

Additional information

This study was financially supported by the Russian Science Foundation (Project No. 19-13-00378: synthesis of compounds 8–11), and the State Task of 2018 (Theme No. 0090-2019-0001: synthesis of compounds 4–7).

For Part 13 see Ref. 1.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 12, pp. 2241–2244, December, 2019.

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Sokolov, V.B., Aksinenko, A.Y., Goreva, T.V. et al. Modification of biologically active amides and amines with fluorine-containing heterocycles. Russ Chem Bull 68, 2241–2244 (2019). https://doi.org/10.1007/s11172-019-2693-y

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  • DOI: https://doi.org/10.1007/s11172-019-2693-y

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