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Development of new antituberculosis drugs among of 1,3- and 1,4-diazines. Highlights and perspectives

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Abstract

The properties of pyrimidine and pyrazine derivatives responsible for the existence of antituberculosis activity are considered. Examples of synthesis and biological activity of the most promising compounds containing the pyrimidine or pyrazine rings in the molecular structure are presented.

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Authors and Affiliations

  1. I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 ul. S. Kovalevskoi, 620137, Ekaterinburg, Russian Federation

    E. V. Verbitskiy, G. L. Rusinov, V. N. Charushin & O. N. Chupakhin

  2. Ural Federal University named after the first President of Russia B. N. Yeltsin, 9 ul. Mira, 620002, Ekaterinburg, Russian Federation

    E. V. Verbitskiy, G. L. Rusinov, V. N. Charushin & O. N. Chupakhin

Authors
  1. E. V. Verbitskiy
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  2. G. L. Rusinov
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  3. V. N. Charushin
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  4. O. N. Chupakhin
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Correspondence to E. V. Verbitskiy.

Additional information

The work was financially supported by the Russian Science Foundation (Project No. 15-13-00077-P).

Based on the materials of the 4th Russian Conference on Medicinal Chemistry with International participation (June 9–14, 2019, Ekaterinburg, Russia).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 12, pp. 2172–2189, December, 2019.

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Verbitskiy, E.V., Rusinov, G.L., Charushin, V.N. et al. Development of new antituberculosis drugs among of 1,3- and 1,4-diazines. Highlights and perspectives. Russ Chem Bull 68, 2172–2189 (2019). https://doi.org/10.1007/s11172-019-2686-x

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  • DOI: https://doi.org/10.1007/s11172-019-2686-x

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