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Synthesis, properties, and antibacterial activity of a new nitric oxide donor — a nitrosyl iron complex with 5-phenyl-1H-1,2,4-triazole-3-thiol

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Abstract

A new binuclear μ-NSC-type nitrosyl iron complex [Fe2(SR)2(NO)4] (R is 5-phenyl-1H-1,2,4-triazole-3-thiolyl) was synthesized. The composition and structure of the newly synthesized complex were determined by atomic absorption, IR, EPR, and Mössbauer spectroscopy and SQUID magnetometry. Amperometric analysis showed that the new complex is an effective nitric oxide (NO) donor in a 1% aqueous DMSO solution. The amounts of NO generated by the complex [Fe2(SR)2(NO)4] in aqueous solutions at physiological pH values were determined. The new complex was shown to have higher antibacterial activity against the gram-positive bacteria Micrococcus luteus compared to kanamycin and streptomycin. According to assays, sulfur-containing ligands of the 1,2,4-triazole-3-thiol series are promising for the design of new antibacterial agents containing the {Fe(NO)2} structural moiety.

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Authors and Affiliations

  1. Institute of Problems of Chemical Physics, Russian Academy of Sciences, 1 prosp. Akad. Semenova, 142432, Chernogolovka, Moscow Region, Russian Federation

    N. A. Sanina, V. A. Mumyatova, A. A. Terent´ev, R. B. Morgunov, N. S. Ovanesyan & A. V. Kulikov

  2. Department of Fundamental Physical and Chemical Engineering, Lomonosov Moscow State University, 1 Leninskie Gory, 119991, Moscow, Russian Federation

    N. A. Sanina & A. A. Terent´ev

  3. Scientific and Educational Center “Medicinal Chemistry”, Moscow State Regional University, 24 ul. Very Voloshinoi, 141014, Mytishchi, Moscow region, Russian Federation

    N. A. Sanina & A. A. Terent´ev

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  1. N. A. Sanina
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  2. V. A. Mumyatova
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  6. A. V. Kulikov
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Correspondence to N. A. Sanina.

Additional information

This study was financially supported by the Russian Foundation for Basic Research (Project No. 17-03-00837).

Based on the materials of the 4th Russian Conference on Medicinal Chemistry with International participation (June 9–14, 2019, Ekaterinburg, Russia).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 12, pp. 2225–2231, December, 2019.

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Sanina, N.A., Mumyatova, V.A., Terent´ev, A.A. et al. Synthesis, properties, and antibacterial activity of a new nitric oxide donor — a nitrosyl iron complex with 5-phenyl-1H-1,2,4-triazole-3-thiol. Russ Chem Bull 68, 2225–2231 (2019). https://doi.org/10.1007/s11172-019-2691-0

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  • DOI: https://doi.org/10.1007/s11172-019-2691-0

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