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Novel derivatives of 3,5-di-tert-butylpyrocatechol with pharmacophore substituents

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Abstract

New potentially bioactive derivatives comprising spatially hindered pyrocatechol linked to hydrazine, acid hydrazides (including isoniazid), and acetylcysteine by a covalent bridge, have been obtained. The structure of the obtained compounds was studied by X-ray diffraction analysis.

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Authors and Affiliations

  1. Scientific Research Institute of Physical and Organic Chemistry, Southern Federal University, 194/2 prosp. Stachki, 344090, Rostov-on-Don, Russian Federation

    L. Yu. Ukhin, D. V. Alexeenko, L. V. Belousova, A. S. Morkovnik, V. A. Podshibyakin, G. S. Borodkin & O. I. Dmitrieva

  2. N. S. Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, 31 Leninsky prosp., 119991, Moscow, Russian Federation

    L. G. Kuz´mina

  3. Federal Research Center Southern Scientific Center of the Russian Academy of Sciences, 41 ul. Chekhova, 344006, Rostov-on-Don, Russian Federation

    E. N. Shepelenko

Authors
  1. L. Yu. Ukhin
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  2. L. G. Kuz´mina
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  3. D. V. Alexeenko
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  4. L. V. Belousova
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  5. A. S. Morkovnik
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  6. E. N. Shepelenko
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  7. V. A. Podshibyakin
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  8. G. S. Borodkin
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  9. O. I. Dmitrieva
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Corresponding author

Correspondence to L. Yu. Ukhin.

Additional information

The work was financially supported by the Russian Ministry of Education and Research (Project No. 4.5821. 2017/8.9) using the equipment of the Center for Collective Use of the Southern Federal University.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 12, pp. 2290–2297, December, 2019.

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Ukhin, L.Y., Kuz´mina, L.G., Alexeenko, D.V. et al. Novel derivatives of 3,5-di-tert-butylpyrocatechol with pharmacophore substituents. Russ Chem Bull 68, 2290–2297 (2019). https://doi.org/10.1007/s11172-019-2702-1

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  • DOI: https://doi.org/10.1007/s11172-019-2702-1

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