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Synthesis and Cytotoxic Activity of a Series of Functionalized Maleopimarimides

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Chemistry of Natural Compounds Aims and scope

New functionalized maleopimarimides were prepared. Their cytotoxicity against tumor cell lines (HeLa, HEp-2) was studied. Diterpenoids 6, 9, and 10 with allene fragments possessed the greatest cytotoxicity and could be considered lead compounds with potential antitumor activity.

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Acknowledgment

The work was performed on a topic of State Task AAAA-A17-117011910025-6 with financial support of the Russian Foundation for Basic Research (Grant No. 18-53-41004) to Ufa Institute of Chemistry, Russian Academy of Sciences and Grant MRU-FA-21/2017 from the Ministry of Innovative Development, Cabinet of Ministers, Republic of Uzbekistan.

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Authors and Affiliations

  1. Ufa Institute of Chemistry, Russian Academy of Sciences, 69 Prosp. Oktyabrya, Ufa, 450054, Russia

    R. N. Malikova, I. M. Sakhautdinov & M. S. Yunusov

  2. S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, 77 Mirzo Ulugbeka St, 700170, Tashkent, Republic of Uzbekistan

    E. O. Terenteva, Z. S. Khashimova & Sh. S. Azimova

Authors
  1. R. N. Malikova
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  2. I. M. Sakhautdinov
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  3. E. O. Terenteva
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  4. Z. S. Khashimova
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  5. M. S. Yunusov
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  6. Sh. S. Azimova
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Corresponding author

Correspondence to I. M. Sakhautdinov.

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Translated from Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2020, pp. 91–93.

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Malikova, R.N., Sakhautdinov, I.M., Terenteva, E.O. et al. Synthesis and Cytotoxic Activity of a Series of Functionalized Maleopimarimides. Chem Nat Compd 56, 101–104 (2020). https://doi.org/10.1007/s10600-020-02953-z

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  • DOI: https://doi.org/10.1007/s10600-020-02953-z

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