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Comparison of two-stage Gamma Knife radiosurgery outcomes for large brain metastases among primary cancers

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Abstract

Purpose

Stereotactic radiosurgery (SRS) is typically considered for patients who cannot undergo surgical resection for large (> 10 cm3) brain metastases (BMs). Staged SRS requires adaptive planning during each stage of the irradiation period for improved tumor control and reduced radiation damage. However, there has been no study on the tumor reduction rates of this method. We evaluated the outcomes of two-stage SRS across multiple primary cancer types.

Methods

We analyzed 178 patients with 182 large BMs initially treated with two-stage SRS. The primary cancers included breast (BC), non-small cell lung (NSCLC), and gastrointestinal tract cancers (GIC). We analyzed the overall survival (OS), neurological death, systemic death (SD), tumor progression (TP), tumor recurrence (TR), radiation necrosis (RN), and the tumor reduction rate during both stages.

Results

The median survival time after the first Gamma Knife surgery (GKS) procedure was 6.6 months. Compared with patients with BC and NSCLC, patients with GIC had shorter OS and a higher incidence of SD. Compared with patients with NSCLC and GIC, patients with BC had significantly higher tumor reduction rates in both sessions. TP rates were similar among primary cancer types. There was no association of the tumor reduction rate with tumor control. The overall cumulative incidence of RN was 4.2%; further, the RN rates were similar among primary cancer types.

Conclusions

Two-stage SRS should be considered for BC and NSCLC if surgical resection is not indicated. For BMs from GIC, staged SRS should be carefully considered and adapted to each unique case given its lower tumor reduction rate and shorter OS.

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Funding

This study received no financial support.

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Authors and Affiliations

  1. Gamma Knife House, Chiba Cerebral and Cardiovascular Center, 575 Tsurumai, Ichihara, Chiba, 2900512, Japan

    Daisuke Ito, Kyoko Aoyagi & Osamu Nagano

  2. Department of Neurological Surgery, Chiba University Graduate School of Medicine, Chiba, Japan

    Yasuo Iwadate & Yoshinori Higuchi

  3. Tokyo Gamma Unit Center, Tsukiji Neurological Clinic, Tokyo, Japan

    Toru Serizawa

Authors
  1. Daisuke Ito
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  2. Kyoko Aoyagi
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  3. Osamu Nagano
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  4. Toru Serizawa
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  5. Yasuo Iwadate
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  6. Yoshinori Higuchi
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Daisuke Ito, Kyoko Aoyagi, Osamu Nagano, Yoshinori Higuchi, and Toru Serizawa. The first draft of the manuscript was written by Daisuke Ito and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Daisuke Ito.

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The authors declare that they have no conflicts of interest.

Research involving human participants

The institutional review board of Chiba Cerebral and Cardiovascular Center IRB (IRB Number: #456) approved this retrospective study.

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Ito, D., Aoyagi, K., Nagano, O. et al. Comparison of two-stage Gamma Knife radiosurgery outcomes for large brain metastases among primary cancers. J Neurooncol 147, 237–246 (2020). https://doi.org/10.1007/s11060-020-03421-y

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  • DOI: https://doi.org/10.1007/s11060-020-03421-y

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