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Green protocol for synthesis of the 3,5-disubstituted 1,2,4-thiadiazoles using N-benzyl-DABCO-tribromide in aqueous media

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Abstract

A novel and simple method for rapid conversion of thioamides to the corresponding 1,2,4-thiadiazole derivatives was developed. It was shown that, thioamides undergo clean and efficient oxidation and cyclization in their conversion to 1,2,4-thiadiazoles using N-benzyl-DABCO-tribromide in wet solid-solid conditions.

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Zali Boeini, H. Green protocol for synthesis of the 3,5-disubstituted 1,2,4-thiadiazoles using N-benzyl-DABCO-tribromide in aqueous media. JICS 6, 547–551 (2009). https://doi.org/10.1007/BF03246534

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  • DOI: https://doi.org/10.1007/BF03246534

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