Abstract
A new type of glycine bridged Cu(II)-containing Schiff base coordination polymer {[Cu2(HL)2](H2O)4}n (1, H3L = (2,2′-(((1E,1′E)-(2-hydroxy-5-methyl-1,3-phenylene)bis(methaneylylidene))bis(azaneylylidene))diacetic acid) was composed by the condensation of glycine, Cu(NO3)2·6H2O as well as 2,6-diformyl-4-methylphenol in the water surrounding. To make the size of complex 1 in nanoscale, a green grinding treatment approach was utilized to generate the nano sheets of complex 1 which has excellent water dispersibility. We firstly constructed the primary focal segmental glomerulosclerosis mice model and evaluate the reduction effect of nano 1 on the level of 24-h urine protein contents. Then, the nf-κb and tlr4 gene expression level was measured by RT-PCR to reveal the mechanism of nano 1. Further, motivated by the drug-like potential that observed from experimental results, the binding interaction has been probed by using molecular docking simulation.
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Zhang, HP., Xu, D., Zhang, J. et al. A New Cu(II)-Containing Coordination Polymer: Crystal Structure, Molecular Docking and Protective Effect on Primary Focal Segmental Glomerulosclerosis by Regulating NF-κB Pathway. J Inorg Organomet Polym 30, 1412–1418 (2020). https://doi.org/10.1007/s10904-019-01353-3
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DOI: https://doi.org/10.1007/s10904-019-01353-3