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A New Kavalactone Dimer from Piper methysticum

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A new kavalactone dimer, named kavalactone A (1), and three known compounds, desmethoxyyangonin (2), yangonin (3), and 11-methoxyyangonin (4), were isolated from the leaves of Piper methysticum (kava). Their structures were determined by spectroscopic methods, mainly 1D and 2D NMR and mass spectrpscopic data. Primary bioassays showed that compound 3 had very strong cytotoxicity against A549 and NCI-H460 Cells with IC50 values of 13.6 and 13.7 μg/mL, respectively, compound 2 had moderate cytotoxicity against A549 and NCI-H460 cells (with IC50 values of 35.8 and 37.6 μg/mL, respectively), and compounds 1 and 4 had very weak cytotoxicity against A549 and NCI-H460 cells.

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Acknowledgment

This research was supported by the Guibei Characteristic Pharmaceutical Resources Research Center Project of Guangxi Province, China (KYA201702).

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Authors and Affiliations

  1. Editorial Department, Guilin Normal College, Guilin, Guangxi Province, 541199, Guangxi, P. R. China

    Jian Xiang Yang

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  1. Jian Xiang Yang
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Correspondence to Jian Xiang Yang.

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Published in Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2019, pp. 524–526.

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Yang, J.X. A New Kavalactone Dimer from Piper methysticum. Chem Nat Compd 55, 606–609 (2019). https://doi.org/10.1007/s10600-019-02759-8

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  • DOI: https://doi.org/10.1007/s10600-019-02759-8

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