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Synthesis, physicochemical investigation and biological studies of Zinc(II) complexes with 1,2,4-triazole Schiff bases

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Abstract

A series of metal complexes of Zn(II) have been synthesized with newly synthesized biologically active 1,2,4-triazole Schiff bases derived from the condensation of 3-substituted-4-amino-5-mercapto-1,2,4-triazole with 8-formyl-7-hydroxy-4-methylcoumarin. The structure of the complexes has been proposed in the light of elemental analyses, spectroscopic data (IR, UV-Vis, 1H NMR and FAB-mass), thermal studies. Electrochemical study of the complexes is also reported. All the complexes are soluble to limited extent in common organic solvents but soluble to larger extent in DMF and DMSO and are non-electrolytes in these two solvent. All these Schiff bases and their complexes have also been screened for their antibacterial (Escherichia. coli, S. aureus, S. pyogenes, P. aeruginosa and Salmonella typhi) and antifungal activities (Aspergillus niger, Aspergillus flavus and cladosporium) by MIC method. The brine shrimp bioassay was also carried out to study their in vitro cytotoxic properties.

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References

  1. I. Kostova, Curr. Med. Chem. -Anti-Cancer Agents 5 (2005) 29.

    CAS  Google Scholar 

  2. A. Scozzafava, C.T. Supuran, J. Med. Chem. 43 (2000) 3677.

    CAS  Google Scholar 

  3. S.A. Rice, M. Givskov, P. Steinberg, S. Kjelleberg, J. Mol. Microbiol. Biotechnol. 1 (1999) 23.

    CAS  Google Scholar 

  4. J.G. Lara, M. Masalha, S.J. Foster, Drug Disc Today 10 (2005) 643.

    Google Scholar 

  5. G.D. Wright, Chem. Biol. 7 (2000) R127.

    Google Scholar 

  6. J. Travis, J. Potempa, Biochim. Biophys Acta 14 (2000) 35.

    Google Scholar 

  7. H.J. Smith, C. Simons, Proteinase Peptidase Inhibition, Recent Potential Targets for Drug Development Taylor and Francis London, 2001.

    Google Scholar 

  8. S.J. Lippard, J.M. Berg, Principles of Bioinorganic Chemistry, University Science Books, Mill Valey, 1999.

    Google Scholar 

  9. Y. Al-Sound, M.N. Al-Dweri, N. Al-Masoudi, Il Farmaco 59 (2004) 775.

    Google Scholar 

  10. H. Michael, C. Dines, J. Mol. Struct. 705 (2004) 177.

    Google Scholar 

  11. Z.H. Chohan, Synth. React. Inorg. Met-Org. Chem. 34 (2004) 833.

    CAS  Google Scholar 

  12. Z.H. Chohan, A. Scozzafava, C.T. Supuran, J. Enz. Inhib. Med. Chem. 17 (2002) 261.

    CAS  Google Scholar 

  13. S.A. Patil, B.M. Badiger, S.M. Kudari, V.H. Kulkarni, Transition Met. Chem 8 (1983) 238.

    CAS  Google Scholar 

  14. B.M. Badiger, S.A. Patil, S.M. Kudari, V.H. Kulkarni, Rev. Roum. Chim 31(1986) 849.

    CAS  Google Scholar 

  15. A.Y. Naik, S.D. Angadi, V.H. Kulkarni, Orient. J. Chem. 10 (1994) 23.

    CAS  Google Scholar 

  16. M.S. Yadawe, S.A. Patil, Trans. Met. Chem. 22 (1997) 220.

    CAS  Google Scholar 

  17. P.G. Avaji, B.N. Reddy, P.S. Badami, S.A. Patil, Trans. Met. Chem. 31 (2006) 842.

    CAS  Google Scholar 

  18. K. Lagannadha Charyulu, K.L. Omprakash, A.V. Chandra Pal, M.L.N Reddy, J. Indian Chem. Soc. LXII (1985) 121.

    Google Scholar 

  19. H.P. Michael, C. Dines, J. Mol. Struct. 705 (2004) 177.

    Google Scholar 

  20. D. Heng-Shan, Q. Bin, W. Kun, W. Qing-Lian, Z. Zi-Yi, Mag. Res. Chem. 38 (2000) 210.

    Google Scholar 

  21. S.S. Papakonstantinou-Garuofalia, E. Tani, O. Todoulou, A. Papadaki-Valiraki, F. Filippators, E.D. Clercq, P.N. Kourounakis, J. Pharm. Pharmacol. 50 (1998) 117.

    Google Scholar 

  22. E. Spath, M. Pailer, Chem. Ber. 68 (1935) 940.

    Google Scholar 

  23. A.L. Vogal, A Text Book of Quantitative Chemical Analysis, fifth Addition Wesley Longman, London, 1999.

    Google Scholar 

  24. G. Singh, P.A. Singh, K. Singh, D.P. Singh, R.N. Handa, S.N. Dubey, Proc. Nat. Acad. Sci. Ind. 72A (2002) 87.

    Google Scholar 

  25. W.J. Geary, Coord. Chem. Rev. 7 (1971) 8.

    Google Scholar 

  26. P.R. Shukla, V.K. Singh, A.M. Jaiswal, J. Narain, J. Ind. Chem. Soc. 60 (1983) 321.

    CAS  Google Scholar 

  27. V.J. Tyaga Raju, Vilas Ranbaore, Vasudha Atre, M.C. Ganorkar, J. Ind. Chem. Soc. LIX (1982) 199.

    Google Scholar 

  28. B.S. Jhaumeer-Laulloo, M.G. Bhowon, Ind. J. Chem. 42A (2003) 2536.

    CAS  Google Scholar 

  29. N.C. Bhardwaj, R.V. Singh, Proc. Indian Acad. Sci. 106 (1994) 15.

    CAS  Google Scholar 

  30. E.W. Ainssough, A.M. Brodie, J. Rangford, J.M. Waters, J. Chem. Soc., Dalton Trans. (1997) 279.

    Google Scholar 

  31. T. James, P. Linnane, S. Shinkai, Chem. Commun. (1996) 281.

    Google Scholar 

  32. J. Yoon, A.W. Czarnik, J. Am. Chem. Soc. 114 (1992) 5874.

    CAS  Google Scholar 

  33. W. Wang, G. Springsreen, G. Shouhai, Wang Binghe, Chem. Commun. (2000) 1283.

    Google Scholar 

  34. T. Burgemeister, R. Grobe-Einster, R. Grotstollen, A. Mannschreck, G. Wulff, Chem. Ber. 114 (1981) 3403.

    CAS  Google Scholar 

  35. E.S. Freeman, Corroll, J. Phys. Chem 62 (1958) 394.

    CAS  Google Scholar 

  36. A.-J. Bard, L.-R. Izatt (Eds.), Electrochemical Methods, Fundamentals and Applications, 2nd ed., Wiley, New York, 2001.

    Google Scholar 

  37. A.K. Sadana, Y. Miraza, K.R. Aneja, O. Prakash, Eur. J. Med. Chem 38 (2003) 533.

    CAS  Google Scholar 

  38. Z.H. Chohan, C.T. Supuran, A. Scozzafava, J. Enz. Inhib. Med. Chem. 19 (2004) 79.

    CAS  Google Scholar 

  39. Z.H. Chohan, M. Praveen, Appl. Organomet Chem. 15 (2001) 617.

    CAS  Google Scholar 

  40. B.N. Meyer, N.R. Ferrigni, J.E. Putnam, L.B. Jacobsen, D.E. Nichols, J.L. McLaughlin, Planta Medica 45 (1982) 31.

    CAS  Google Scholar 

  41. A.W. Bauer, W.M. Kirby, J.C. Sherris, M. Turck, Clin. Pathol. 45 (1966) 493.

    CAS  Google Scholar 

  42. T. Kaliyappan, S. Rajagopan, P. Kannan, J. Appl. Polym. Sci. 91 (2003) 494.

    Google Scholar 

  43. G.S.V. Kumar, B. Mathew, J. Mac. Sci. 41 (2004) 1037.

    Google Scholar 

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Authors and Affiliations

  1. P. G. Department of Chemistry Karnatak University, Dharwad, 580003, Karnataka, India

    G. B. Bagihalli & S. A. Patil

  2. Department of Chemistry, Shri Sharanabasaveswar College of Science, Gulbarga, 585 102, India

    P. S. Badami

Authors
  1. G. B. Bagihalli
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  2. S. A. Patil
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  3. P. S. Badami
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Correspondence to S. A. Patil.

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Bagihalli, G.B., Patil, S.A. & Badami, P.S. Synthesis, physicochemical investigation and biological studies of Zinc(II) complexes with 1,2,4-triazole Schiff bases. JICS 6, 259–270 (2009). https://doi.org/10.1007/BF03245833

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  • DOI: https://doi.org/10.1007/BF03245833

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