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Sonochemical Decoration of Graphene Oxide with Magnetic Fe3O4@CuO Nanocomposite for Efficient Click Synthesis of Coumarin-Sugar Based Bioconjugates and Their Cytotoxic Activity

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Abstract

A magnetic nanocomposite of GO-Fe3O4@CuO was fabricated via a simple sonochemical technique and successfully utilized for the ultrasound promoted synthesis of regioselective 1,4-disubstituted mono/bis/tris-1,2,3-triazoles (3a–k). This catalyst could be separated conveniently from the reaction mixture using an external magnet and reused up to eight consecutive runs without noticeable drop in the desired product yield. Other noteworthy features of this green protocol are negligible metal leaching from the support during reaction, high yield in lesser time, aqueous media and good results with gram scale synthesis. Representative compounds were also screened for their cytotoxic activity against PC-12 cell line using standard MTT assay and flow cytometry. Trifluoromethyl group containing triazole derivative (3f) displayed cytotoxic activity (IC50 8.3 µg/mL) comparable to the standard drug cisplatin (IC50 5.8 µg/mL).

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Acknowledgements

Authors are thankful to Materials Research Centre, MNIT Jaipur for providing spectral facilities. Y. Jain and M. Kumari are acknowledges to MNIT Jaipur for providing financial assistance and DST, New Delhi for awarding INSPIRE fellowship scheme (IF140506) respectively.

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Authors and Affiliations

  1. Department of Chemistry, Malaviya National Institute of Technology Jaipur, Jaipur, 302017, India

    Yachana Jain, Mitlesh Kumari & Ragini Gupta

  2. Materials Research Centre, Malaviya National Institute of Technology Jaipur, Jaipur, 302017, India

    Ragini Gupta

  3. School of Pharmaceutical Sciences, Shoolini University, Solan, 173229, India

    Raman Preet Singh & Deepak Kumar

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  1. Yachana Jain
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  2. Mitlesh Kumari
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  3. Raman Preet Singh
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  4. Deepak Kumar
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  5. Ragini Gupta
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Correspondence to Ragini Gupta.

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Jain, Y., Kumari, M., Singh, R.P. et al. Sonochemical Decoration of Graphene Oxide with Magnetic Fe3O4@CuO Nanocomposite for Efficient Click Synthesis of Coumarin-Sugar Based Bioconjugates and Their Cytotoxic Activity. Catal Lett 150, 1142–1154 (2020). https://doi.org/10.1007/s10562-019-02982-6

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