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Combined bioscaffold with stem cells and exosomes can improve traumatic brain injury

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Abstract

The intricacy of the brain, along with the existence of blood brain barrier (BBB) does complicate the delivery of effective therapeutics through simple intravascular injection. Hence, an effective delivery mechanism of therapeutics in the event of either traumatic brain injury (TBI) or other brain injuries is needed. Stem cells can promote regeneration and repair injury. The usage of biomaterials and exosomes in transporting stem cells to target lesion sites has been suggested as a potential option. The combination of biomaterials with modified exosomes can help in transporting stem cells to injury sites, whiles also increasing their survival and promoting effective treatment. Herein, we review the current researches pertinent to biological scaffolds and exosomes in repairing TBI and present the current progress and new direction in the clinical setting. We begin with the role of bioscaffold in treating neuronal conditions, the effect of exosomes in injury, and conclude with the improvement of TBI via the employment of combined exosomes, bioscaffold and stem cells.

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Funding

This work was supported by the Natural Science Foundation of Zhejiang Province (no. LY19H170001).

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Authors and Affiliations

  1. Department of Histology and Embryology, Medical College, Shaoxing University, 312000, Shaoxing, Zhejiang, China

    Jiaying Yuan, Yong Zhang, Xizhi Wang & Xuehong Liu

  2. Institute of Neuroscience, Zhejiang University School of Medicine, Hangzhou, China

    Benson O. A. Botchway

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  1. Jiaying Yuan
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  2. Benson O. A. Botchway
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  3. Yong Zhang
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  4. Xizhi Wang
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XL designed the study. JY, BOAB, YZ, XW and XL prepared the first draft of the manuscript. JY, BOAB, YZ, XW and XL revised the manuscript. All authors approved the final paper.

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Correspondence to Xuehong Liu.

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Yuan, J., Botchway, B.O.A., Zhang, Y. et al. Combined bioscaffold with stem cells and exosomes can improve traumatic brain injury. Stem Cell Rev and Rep 16, 323–334 (2020). https://doi.org/10.1007/s12015-019-09927-x

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