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InCl3 as an efficient catalyst for synthesis of oxazolines under thermal, ultrasonic and microwave irradiations

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Abstract

Efficient synthesis of 2-oxazolines by the reaction of nitriles with β-aminoalcohols using InCl3 as catalyst under reflux conditions is reported. This catalyst can be successfully applied to the chemoselective conversion of dicyanobenzenes to their corresponding mono- and bis-oxazolines. The application of ultrasonic and microwave irradiation improved the yields and reduced the reaction times. Another advantage of this catalytic system is its ability to carry out large-scale reactions under ultrasonic and MW irradiations. Alkylnitriles such as acetonitrile was also converted to its corresponding 2-methyloxazoline in the presence of catalytic amounts of InCl3.

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Authors and Affiliations

  1. Department of Chemistry, Catalysis Division, University of Isfahan, Isfahan, 81746-73441, Iran

    M. Moghadam, V. Mirkhani, S. Tangestaninejad, I. Mohammadpoor-Baltork & H. Kargar

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  1. M. Moghadam
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  2. V. Mirkhani
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  3. S. Tangestaninejad
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  4. I. Mohammadpoor-Baltork
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  5. H. Kargar
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Correspondence to M. Moghadam.

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Moghadam, M., Mirkhani, V., Tangestaninejad, S. et al. InCl3 as an efficient catalyst for synthesis of oxazolines under thermal, ultrasonic and microwave irradiations. JICS 6, 251–258 (2009). https://doi.org/10.1007/BF03245832

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