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Fabrication and Characterization of Biodegradable pH-Responsive Halloysite Poly(lactic-co-glycolic acid) Micro-sphere for Controlled Released of Phenytoin Sodium

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Abstract

In this paper, new porous pH-responsive microspheres based on functionalized halloysite nanotubes (HNTs) with poly-lactic-co-glycolic acid (PLGA) are investigated as the phenytoin sodium (PHT-Na) carrier. For this purpose, the surfaces of HNTs were modified by a silane coupling agent, (3-aminopropyl)triethoxysilane (APTES) and then the desired microsphere was synthesized through PLGA coating on modified HNTs. Formation of these hybrid particles are confirmed using various characterization methods like Fourier transform infrared (FT-IR), transmission electron microscope (TEM), scanning electron microscope (SEM), EDX, zeta-potential, and X-ray diffraction. The results of the FT-IR spectrum show the presence of APTES, PHT-Na and PLGA peaks, which supported the modification of HNTs and drug capsulation. TEM images confirm the presence of APTES on HNTs, due to the increase in outer diameter. SEM images displayed that by grafting PLGA polymer to modified HNTs, the shape of nanotubes has changed from rod-like to microsphere. Hence, the prospering connection of APTES and PLGA on HNTs was emphasized by zeta-potential results. Moreover, the profile of drug release is recorded via HPLC. In vitro drug release tests show that both the presence of polymer chains around drug containers and the pH value of the release medium play an important role in controlled release. Eventually, the kinetics of drug release was evaluated based on Korsmeyer–Peppas kinetic model.

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Authors and Affiliations

  1. Department of Polymer and Chemical Engineering, South Tehran Branch, Islamic Azad University, Tehran, Iran

    Hassan Malakinezhad & Mohammadreza Kalaee

  2. Department of Chemistry, Amirkabir University of Technology, Tehran, Iran

    Majid Abdouss & Alireza Mohebali

  3. Department of Polymer Engineering and Color Technology, Amirkabir University of Technology, Tehran, Iran

    Mahsa Hakani

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  1. Hassan Malakinezhad
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  2. Mohammadreza Kalaee
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  3. Majid Abdouss
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  4. Alireza Mohebali
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  5. Mahsa Hakani
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Correspondence to Mohammadreza Kalaee.

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Malakinezhad, H., Kalaee, M., Abdouss, M. et al. Fabrication and Characterization of Biodegradable pH-Responsive Halloysite Poly(lactic-co-glycolic acid) Micro-sphere for Controlled Released of Phenytoin Sodium. J Inorg Organomet Polym 30, 722–730 (2020). https://doi.org/10.1007/s10904-019-01263-4

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  • DOI: https://doi.org/10.1007/s10904-019-01263-4

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