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Polyelectrolyte nanoparticles based on functionalized silica and pillar[5]arene derivatives for recognition of model proteins

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Abstract

The paper reports the first synthesis of positively charged hybrid organic-inorganic silicon dioxide nanoparticles with an average particle diameter of 28 nm modified with 1-[3-(diethylamino)propyl]-3-[3-(triethoxysilyl)propyl]urea and pillar[5]arene derivatives containing negatively charged groups, which form nanoparticles with an average diameter of 40 nm in an aqueous solution. These nanoparticles were utilized in a new procedure developed for the preparation of mixed polyelectrolyte particles. Spectroscopic studies (UV spectroscopy, dynamic light scattering) showed that the resulting compounds are able to recognize biopolymers, proteins (bovine serum albumin and lysozyme).

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Correspondence to A. A. Nazarova or I. I. Stoikov.

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Based on the materials of the V International Scientific Conference “Advances in Synthesis and Complexing” (April 22–26, 2019, Moscow, Russia).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2065–2074, November, 2019.

This study was financially supported by the Russian Science Foundation (Project No. 18-73-10094).

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Ziatdinova, R.V., Nazarova, A.A., Yakimova, L.S. et al. Polyelectrolyte nanoparticles based on functionalized silica and pillar[5]arene derivatives for recognition of model proteins. Russ Chem Bull 68, 2065–2074 (2019). https://doi.org/10.1007/s11172-019-2667-0

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  • DOI: https://doi.org/10.1007/s11172-019-2667-0

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