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NaIO4-catalyzed one-pot synthesis of dihydropyrimidinones at room temperature under solvent-free conditions

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Abstract

Sodium periodate efficiently catalyzed the three-component Biginelli reaction of an aldehyde, α β-keto ester or β-keto ketone, and urea or thiourea at room temperature under solvent-free conditions and afforded the corresponding 3,4-dihydropyrimidine-2-(1H)-ones in excellent yields.

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Authors and Affiliations

  1. College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225002, P. R. China

    X. Jing, Z. Li, X. Pan, Y. Shi & C. Yan

Authors
  1. X. Jing
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  2. Z. Li
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  3. X. Pan
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  4. Y. Shi
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  5. C. Yan
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Correspondence to X. Jing.

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Jing, X., Li, Z., Pan, X. et al. NaIO4-catalyzed one-pot synthesis of dihydropyrimidinones at room temperature under solvent-free conditions. JICS 6, 514–518 (2009). https://doi.org/10.1007/BF03246529

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  • DOI: https://doi.org/10.1007/BF03246529

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