Abstract
Magnetic molecularly imprinted polymers (MMIPs) were synthesized on Fe3O4 using methacrylic acid (MAA) and acrylamide (AA) as monomers, ethylene glycol dimethacrylate (EGDMA) as cross-linker and rutin as a template under nitrogen atmosphere in about 90 min. Fourier transform infrared spectroscopy, electron microscopy, vibrating sample magnetometer (VSM), thermo-gravimetric analysis (TGA), and Brunauer–Emmett–Teller (BET) surface area analysis were used for particles characterization. Data showed that MMIPs was well synthesized and had high porosity. Synthetic MMIPs using methacrylic acid had much better performance than synthetic MMIPs using acrylamide. MMIPs were used for rapid separation and determination of rutin. MMIPs solid-phase extraction coupled with UV–visible spectrophotometer method was established for rutin analysis in green tea sample. The developed method had good linear dynamic range (1–90 µM, R2 = 0.996), with a detection limit as low as 0.961 µM, precision (1.5–2.1%) and accuracy (103.1–110.9%).
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Separation of rutin by magnetic molecular-imprinted polymers
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Benito-Pena E, Gonzalez-Vallejo V, Rico-Yuste A, Barbosa-Pereira L, Manuel Cruz J, Bilbao Alvarez-Lorenzo C, Moreno-Bondi MC (2016) Molecularly imprinted hydrogels as functional active packaging materials. Food Chem 190:487–494. https://doi.org/10.1016/j.foodchem.2015.05.128
Dubber MJ, Sewram V, Mshicileli N, Shephard GS, Kanfer I (2005) The simultaneous determination of selected flavonol glycosides and aglycones in Ginkgo biloba oral dosage forms by high-performance liquid chromatography–electrospray ionization–mass spectrometry. J Pharmaceut Biomed 37:723–731. https://doi.org/10.1016/j.jpba.2004.11.052
Duenas M, Surco-Laos F, Gonzalez-Manzano S, Gonzalez-Paramas AM, Santos-Buelga C (2011) Antioxidant properties of major metabolites of quercetin. Eur Food Res Technol 232:103–111. https://doi.org/10.1007/s00217-010-1363-y
Ersoy S, Tutem KE, Baskan K, Apak SR, Nergizc C (2016) Preparation, characterization and usage of molecularly imprinted polymer for the isolation of quercetin from hydrolyzed nettle extract. J Chromatogr B 1017–1018:89–100. https://doi.org/10.1016/j.jchromb.2016.02.034
Guardia T, Rotelli AE, Juarez AO, Pelzer LE (2001) Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat. Farmaco 56:683–687. https://doi.org/10.1016/S0014-827X(01)01111-9
Hassan H, Barsoum B, Habib I (1999) Simultaneous spectrophotometric determination of rutin, quercetin and ascorbic acid in drugs using a Kalman Filter approach. J Pharm Biomed Anal 20:315. https://doi.org/10.1016/S0731-7085(99)00048-5
He C, Cui H, Zhao X, Zhao H, Zhao G (1999) Determination of rutin by flow injection with inhibited chemiluminescence detection. Anal Lett 32:275. https://doi.org/10.1080/00032719908543003
Huang WY, Cai YZ (2010) Natural phenolic compounds from medicinal herbs and dietary plants: potential use for cancer prevention. Nutr Cancer 62:1–20. https://doi.org/10.1080/01635580903191585
Ishii K, Furuta T, Kasuya Y (2003) High-performance liquid chromatographic determination of quercetin in human plasma and urine utilizing solid-phase extraction and ultraviolet detection. J Chromatogr B 794:49–56. https://doi.org/10.1016/S1570-0232(03)00398-2
Landolfi R, Mower RL, Steiner M (1984) Modification of platelet function and arachidonic acid metabolism by bioflavonoid. Biochem Pharmacol 33:1525–1530. https://doi.org/10.1016/0006-2952(84)90423-4
Legnerová Z, Šatíský D, Solich P (2003) Using on-line solid phase extraction for simultaneous determination of ascorbic acid and rutin trihydrate by sequential injection analysis. Anal Chim Acta 497:165. https://doi.org/10.1007/00604-011-0568-5
Lopez MMC, Perez MCC, Garcia MSD, Vilarino JML, Rodriguez MVG, Losada LFB (2012) Preparation, evaluation and characterization of quercetin-molecularly imprinted polymer for preconcentration and clean-up of catechins. Anal Chim Acta 721:68–78. https://doi.org/10.1016/j.aca.2012.01.049
Molnar-Perl I, Fuzfai Z (2005) Chromatographic, capillary electrophoretic and capillary electrochromatographic techniques in the analysis of flavonoids. J Chromatogr A 1073:201–227. https://doi.org/10.1016/j.chroma.2004.10.068
Piacham T, Isarankura-Na-Ayudhya C, Prachayasittikul V (2015) Quercetin-imprinted polymer for anthocyanin extraction from mangosteen pericarp. Mater Sci Eng C 51:127–131. https://doi.org/10.1016/j.msec.2015.02.051
Qingjiang W, Fei D, Hui L, Pingang H, Yuzhi F (2003) Determination of hydrochlorothiazide and rutin in Chinese herb medicines and human urine by capillary zone electrophoresis with amperometric detection. J Pharm Biomed Anal 30:1507–1514. https://doi.org/10.1016/0731-7085(02)00540
Saad EM, Madbouly A, Ayoub N, El Nashar RM (2015) Preparation and application of molecularly imprinted polymer for isolation of chicoric acid from Chicorium intybus L. medicinal plant. Anal Chim Acta 877:80–89. https://doi.org/10.1016/j.aca.2015.03.047
Safdariana M, Ramezania Z, Ghadiri AA (2016) Facile synthesis of magnetic molecularly imprinted polymer: perphenazine template and its application in urine and plasma analysis. J Chromatogr A 1455:28–36. https://doi.org/10.1016/j.chroma.2016.05.083
Sakkiadi AV, Stavrakakis MN, Haroutounian SA (2001) Direct HPLC assay of five biologically interesting phenolic antioxidants in varietal Greek red wines. LWT Food Sci Technol 34:410–413. https://doi.org/10.1006/fstl.2001.0792
Song X, Li J, Wang J, Chen L (2009) Quercetin molecularly imprinted polymers: preparation, recognition characteristics and properties as sorbent for solid-phase extraction. Talanta 80:694–702. https://doi.org/10.1016/j.talanta.2009.07.051
Sun W, Yang M, Li Y, Jiang Q, Liu S, Jiao K (2008) Electrochemical behavior and determination of rutin on a pyridinium-based ionic liquid modified carbon paste electrode. J Pharm Biomed Anal 48:1326. https://doi.org/10.1016/2008.09.014
Xia S, Zhanga K, Xiaoa D, Hea H (2016) Computational-aided design of magnetic ultra-thin dummy molecularly imprinted polymer for selective extraction and determination of morphine from urine by high-performance liquid chromatography. J Chromatogr A 1473:1–9. https://doi.org/10.1016/j.chroma.2016.09.074
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Reza Tabaraki declares that he has no conflict of interest. Negar Sadeghinejad declares that she has no conflict of interest.
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Tabaraki, R., Sadeghinejad, N. Preparation and application of magnetic molecularly imprinted polymers for rutin determination in green tea. Chem. Pap. 74, 1937–1944 (2020). https://doi.org/10.1007/s11696-019-01039-7
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DOI: https://doi.org/10.1007/s11696-019-01039-7