Abstract
To evaluate the safety and efficacy of Glycyrrhiza uralensis root extracts produced using artificial hydroponic and artificial hydroponic-field hybrid cultivation systems, we investigated anti-allergic action in mice using IgE-mediated immediate hypersensitivity. Hot water extracts obtained from the roots of Glycyrrhiza uralensis cultivated using two systems were orally administered at a dose of 100 mg/kg as glycyrrhizin (GL) and compared with the commercial crude drug, Glycyrrhizae Radix. Both the artificial hydroponic and artificial hydroponic-field hybrid cultivated root extracts showed anti-allergic effects on IgE-mediated immediate hypersensitivity in mice, as did the commercial crude drugs. These results highlight the potential for artificially cultivated roots of Glycyrrhiza uralensis to be used as an alternative medicinal source.
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Acknowledgements
This study was supported by a Health and Labour Sciences Research grant from the Ministry of Health, Labour and Welfare of Japan, and a research and development grant from the Japan Agency for Medicinal Research and Development (AMED: 15ak0101034h0001). The authors would like to thank the Japan Kampo Medicines Manufacturers Association and the Japan Medicinal Plant Federation for providing the commercial crude drugs, Glycyrrhiza Radix. We would like to thank Editage (www.editage.jp) for English language editing.
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Nose, M., Tsutsui, R., Hisaka, S. et al. Evaluation of the safety and efficacy of Glycyrrhiza uralensis root extracts produced using artificial hydroponic and artificial hydroponic-field hybrid cultivation systems III: anti-allergic effects of hot water extracts on IgE-mediated immediate hypersensitivity in mice. J Nat Med 74, 463–466 (2020). https://doi.org/10.1007/s11418-019-01378-5
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DOI: https://doi.org/10.1007/s11418-019-01378-5