Skip to main content

Advertisement

SpringerLink
Log in

Metals/Metalloids and Oxidative Status Markers in Saltwater Fish from the Ionic Coast of Sicily, Mediterranean Sea

  • Research paper
  • Published:
International Journal of Environmental Research Aims and scope Submit manuscript

Abstract

The aim of the present work was the assessment of the environmental status of marine biota along the Sicilian ionic coast (Italy). Due to its complex habitat requirements, the fish fauna is a crucial indicator of the ecological integrity of aquatic systems at different scales, from micro-habitat to catchment. Besides environmental contaminants, biomarkers of oxidative stress answer to the Water Framework Directive’s challenges for improved detection of the impacts of chemical compounds on aquatic organisms. Highly consumed seafood species (Solea solea, Mullus barbatus, Sardina pilchardus and Scomber scombrus) were taken at the Gulf of Catania (Sicily). Levels of metals/metalloids (As, Cd, Cr, Cu, Fe, Hg, Mn, Ni, Pb, Se, V, Zn) were estimated in muscle tissue as well as oxidative stress parameter such as malondialdehyde (MDA) and protein carbonyl (PC) derivatives in liver. The total metals/metalloids load indicated as Metal Pollution Index (MPI, unitless) were the following: 0.258 in S. pilchardus, 0.203 in S. scombrus, 0.123 in M. barbatus and 0.071 in S. solea. The greatest contribution was given by As (mean range 2.670–9.748 mg/kg wet weight) and Zn (mean range 2.169–4.736 wet weight) levels. Hg, Ni and Zn presented mean levels progressively higher, with increasing trophic position. From a chemical point of view, the analyzed species were healthy for human consumption and the risk to develop chronic systemic and carcinogenic effects was low; nevertheless, it has highlighted an oxidative stress condition.

Article Highlights

  • Highly consumed seafood species, caught in the Gulf of Catania, were chosen for metals determination.

  • Malondialdehyde (MDA) and protein carbonyl (PC) derivatives were analysed in liver.

  • From a chemical point of view, the analysed species are healthy for human consumption.

  • Nevertheless, fish species resulted stressed by environmental conditions

  • MDA and PC are sensitive indicators of low degree of aquatic pollution.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  • Abarikwu SO, Essien EB, Iyede O-O, John K, Mgbudom-Okah C (2017) Biomarkers of oxidative stress and health risk assessment of heavy metal contaminated aquatic and terrestrial organisms by oil extraction industry in Ogale, Nigeria. Chemosphere 185:412–422. https://doi.org/10.1016/j.chemosphere.2017.07.024

    Article  CAS  Google Scholar 

  • Abdelazim AM, Saadeldin IM, Swelum AA-A, Afifi MM, Alkaladi A (2018) Oxidative stress in the muscles of the fish nile tilapia caused by zinc oxide nanoparticles and its modulation by vitamins C and E. Oxid Med Cell Longev 2018:6926712. https://doi.org/10.1155/2018/6926712

    Article  CAS  Google Scholar 

  • Akbary P, Sartipi Yarahmadi S, Jahanbakhshi A (2018) Hematological, hepatic enzymes’ activity and oxidative stress responses of gray mullet (Mugil cephalus) after sub-acute exposure to copper oxide. Environ Sci Pollut Res Int 25:1800–1808. https://doi.org/10.1007/s11356-017-0582-1

    Article  CAS  Google Scholar 

  • Alkaladi A (2019) Vitamins E and C ameliorate the oxidative stresses induced by zinc oxide nanoparticles on liver and gills of Oreochromis niloticus. Saudi J Biol Sci 26:357–362. https://doi.org/10.1016/j.sjbs.2018.07.001

    Article  CAS  Google Scholar 

  • Allan IJ, Vrana B, Greenwood R, Mills GA, Roig B, Gonzalez C (2006) A “toolbox” for biological and chemical monitoring requirements for the European Union’s Water Framework Directive. Talanta 69:302–322. https://doi.org/10.1016/j.talanta.2005.09.043

    Article  CAS  Google Scholar 

  • Am Pappalardo, Copat C, Ferrito V, Grasso A, Ferrante M (2017) Heavy metal content and molecular species identification in canned tuna: insights into human food safety. Mol Med Rep 15:3430–3437. https://doi.org/10.3892/mmr.2017.6376

    Article  CAS  Google Scholar 

  • Arabi M, Alaeddini MA (2005) Metal-ion-mediated oxidative stress in the gill homogenate of rainbow trout (Oncorhynchus mykiss): antioxidant potential of manganese, selenium, and albumin. Biol Trace Elem Res 108:155–168. https://doi.org/10.1385/BTER:108:1-3:155

    Article  CAS  Google Scholar 

  • Arena G, Copat C, Dimartino A, Grasso A, Fallico R, Sciacca S, Fiore M, Ferrante M (2015) Determination of total vanadium and vanadium(V) in groundwater from Mt. Etna and estimate of daily intake of vanadium(V) through drinking water. J Water Health 13:522–530. https://doi.org/10.2166/wh.2014.209

    Article  Google Scholar 

  • Ates B, Orun I, Talas ZS, Durmaz G, Yilmaz I (2008) Effects of sodium selenite on some biochemical and hematological parameters of rainbow trout (Oncorhynchus mykiss Walbaum, 1792) exposed to Pb2 + and Cu2+. Fish Physiol Biochem 34:53–59. https://doi.org/10.1007/s10695-007-9146-5

    Article  CAS  Google Scholar 

  • Ayala A, Muñoz MF, Argüelles S (2014) Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxid Med Cell Longev. https://doi.org/10.1155/2014/360438

    Article  Google Scholar 

  • Balogh K, Weber M, Erdélyi M, Mézes M (2007) Investigation of lipid peroxide and glutathione redox status of chicken concerning on high dietary selenium intake. Acta Biol Hung 58:269–279. https://doi.org/10.1556/ABiol.58.2007.3.3

    Article  CAS  Google Scholar 

  • Banni M, Chouchene L, Said K, Kerkeni A, Messaoudi I (2011) Mechanisms underlying the protective effect of zinc and selenium against cadmium-induced oxidative stress in zebrafish Danio rerio. Biometals. Int J Role Met Ions Biol Biochem Med 24:981–992. https://doi.org/10.1007/s10534-011-9456-z

    Article  CAS  Google Scholar 

  • Berntssen MHG, Sundal TK, Olsvik PA, Amlund H, Rasinger JD, Sele V, Hamre K, Hillestad M, Buttle L, Ørnsrud R (2017) Sensitivity and toxic mode of action of dietary organic and inorganic selenium in Atlantic salmon (Salmo salar). Aquat Toxicol 192:116–126. https://doi.org/10.1016/j.aquatox.2017.09.014

    Article  CAS  Google Scholar 

  • Bonilla E, Contreras R, Medina-Leendertz S, Mora M, Villalobos V, Bravo Y (2012) Minocycline increases the life span and motor activity and decreases lipid peroxidation in manganese treated Drosophila melanogaster. Toxicology 294:50–53. https://doi.org/10.1016/j.tox.2012.01.016

    Article  CAS  Google Scholar 

  • Burk RF (2002) Selenium, an antioxidant nutrient. Nutr Clin Care Off Publ Tufts Univ 5:75–79

    Article  Google Scholar 

  • Cappon CJ, Smith JC (1982) Chemical form and distribution of mercury and selenium in canned tuna. J Appl Toxicol 2:181–189

    Article  CAS  Google Scholar 

  • Chovanec A, Hofer R, Schiemer F (2003) Chapter 18 Fish as bioindicators. In: Markert BA, Breure AM, Zechmeister HG (eds) Trace metals and other contaminants in the environment, bioindicators & biomonitors. Elsevier, Amsterdam, pp 639–676. https://doi.org/10.1016/S0927-5215(03)80148-0

    Chapter  Google Scholar 

  • Conti GO, Copat C, Ledda C, Fiore M, Fallico R, Sciacca S, Ferrante M (2012) Evaluation of heavy metals and polycyclic aromatic hydrocarbons (PAHs) in Mullus barbatus from Sicily Channel and risk-based consumption limits. Bull Environ Contam Toxicol 88:946–950. https://doi.org/10.1007/s00128-012-0611-1

    Article  CAS  Google Scholar 

  • Copat C, Brundo MV, Arena G, Grasso A, Oliveri Conti G, Ledda C, Fallico R, Sciacca S, Ferrante M (2012a) Seasonal variation of bioaccumulation in Engraulis encrasicolus (Linneaus, 1758) and related biomarkers of exposure. Ecotoxicol Environ Saf 86:31–37. https://doi.org/10.1016/j.ecoenv.2012.09.006

    Article  CAS  Google Scholar 

  • Copat C, Maggiore R, Arena G, Lanzafame S, Fallico R, Sciacca S, Ferrante M (2012b) Evaluation of a temporal trend heavy metals contamination in Posidonia oceanica (L.) Delile, (1813) along the western coastline of Sicily (Italy). J Environ Monit 14:187–192. https://doi.org/10.1039/C1EM10575B

    Article  CAS  Google Scholar 

  • Copat C, Arena G, Fiore M, Ledda C, Fallico R, Sciacca S, Ferrante M (2013) Heavy metals concentrations in fish and shellfish from eastern Mediterranean Sea: consumption advisories. Food Chem Toxicol Int JPubl Br Ind Biol Res Assoc 53:33–37. https://doi.org/10.1016/j.fct.2012.11.038

    Article  CAS  Google Scholar 

  • Copat C, Vinceti M, D’Agati MG, Arena G, Mauceri V, Grasso A, Fallico R, Sciacca S, Ferrante M (2014) Mercury and selenium intake by seafood from the Ionian Sea: a risk evaluation. Ecotoxicol Environ Saf 100:87–92. https://doi.org/10.1016/j.ecoenv.2013.11.009

    Article  CAS  Google Scholar 

  • Copat C, Grasso A, Fiore M, Cristaldi A, Zuccarello P, Signorelli SS, Conti GO, Ferrante M (2018) Trace elements in seafood from the Mediterranean sea: an exposure risk assessment. Food Chem Toxicol Int J Publ Br Ind Biol Res Assoc 115:13–19. https://doi.org/10.1016/j.fct.2018.03.001

    Article  CAS  Google Scholar 

  • Dalle-Donne I, Rossi R, Giustarini D, Milzani A, Colombo R (2003) Protein carbonyl groups as biomarkers of oxidative stress. Clin Chim Acta Int J Clin Chem 329:23–38

    Article  CAS  Google Scholar 

  • Das D, Moniruzzaman M, Mukhopadhyay S, Karan S, Sarbajna A, Chakraborty SB (2018) Impact of metal toxicity on oxidative balance and mitochondrial enzyme function in muscle of Tilapia. Bull Environ Contam Toxicol 100:647–652. https://doi.org/10.1007/s00128-018-2303-y

    Article  CAS  Google Scholar 

  • Davies MJ, Fu S, Wang H, Dean RT (1999) Stable markers of oxidant damage to proteins and their application in the study of human disease. Free Radic Biol Med 27:1151–1163

    Article  CAS  Google Scholar 

  • de Oliveira LF, Santos C, Risso WE, Martinez CBDR (2018) Triple-mixture of Zn, Mn and Fe increases bioaccumulation and causes oxidative stress in freshwater neotropical fish. Environ Toxicol Chem. https://doi.org/10.1002/etc.4133

    Article  Google Scholar 

  • Dean RT, Fu S, Stocker R, Davies MJ (1997) Biochemistry and pathology of radical-mediated protein oxidation. Biochem J 324:1–18

    Article  CAS  Google Scholar 

  • Del Rio D, Stewart AJ, Pellegrini N (2005) A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316–328. https://doi.org/10.1016/j.numecd.2005.05.003

    Article  Google Scholar 

  • Droutsa A, Emmanouil N, Raptopoulos K, Salvaggio A, Mazzei V, Pecoraro R, Messina G, Copat C, Ferrante M, Brundo MV, Lombardo BM (2019) Trace elements bioaccumulation in Porcellionides pruinosus (Brandt, 1833) and related biomarkers of exposure. Res Tech, Microsc. https://doi.org/10.1002/jemt.23211

    Book  Google Scholar 

  • Reg. EC (2006) Commission Regulation (EC) N. 1881/2006 of 19 December 2006 setting maximum levels for certain contaminants in foodstuffs

  • Ensibi C, Daly Yahia MN (2017) Toxicity assessment of cadmium chloride on planktonic copepodsCentropages ponticususing biochemical markers. Toxicol Rep 4:83–88. https://doi.org/10.1016/j.toxrep.2017.01.005

    Article  CAS  Google Scholar 

  • EPA3051A (2017) Microwave assisted acid digestion of sediments, sludges, soils, and oils

  • Eybl V, Kotyzová D (2010) Protective effect of manganese in cadmium-induced hepatic oxidative damage, changes in cadmium distribution and trace elements level in mice. Interdiscip Toxicol 3:68–72. https://doi.org/10.2478/v10102-010-0013-3

    Article  CAS  Google Scholar 

  • Fairweather-Tait SJ, Collings R, Hurst R (2010) Selenium bioavailability: current knowledge and future research requirements. Am J Clin Nutr 91:1484S–1491S. https://doi.org/10.3945/ajcn.2010.28674J

    Article  CAS  Google Scholar 

  • Farombi EO, Adelowo OA, Ajimoko YR (2007) Biomarkers of oxidative stress and heavy metal levels as indicators of environmental pollution in African cat fish (Clarias gariepinus) from Nigeria Ogun River. Int J Environ Res Public Health 4:158–165

    Article  CAS  Google Scholar 

  • FDA (2000) Analytical procedures and methods validation: chemistry, manufacturing, and controls. Federal Regist (Not) 65:776–777

    Google Scholar 

  • Ferrante M, Copat C, Mauceri C, Grasso A, Schilirò T, Gilli G (2015) The importance of indicators in monitoring water quality according to European directives. Epidemiol Prev 39:71–75

    Google Scholar 

  • Ferrante M, Pappalardo AM, Ferrito V, Pulvirenti V, Fruciano C, Grasso A, Sciacca S, Tigano C, Copat C (2017) Bioaccumulation of metals and biomarkers of environmental stress in Parablennius sanguinolentus (Pallas, 1814) sampled along the Italian coast. Mar Pollut Bull 122:288–296. https://doi.org/10.1016/j.marpolbul.2017.06.060

    Article  CAS  Google Scholar 

  • Ferrante M, Signorelli SS, Ferlito SL, Grasso A, Dimartino A, Copat C (2018a) Groundwater-based water wells characterization from Guinea Bissau (Western Africa): a risk evaluation for the local population. Sci Total Environ 619–620:916–926. https://doi.org/10.1016/j.scitotenv.2017.11.176

    Article  CAS  Google Scholar 

  • Ferrante M, Spena MT, Hernout BV, Grasso A, Messina A, Grasso R, Agnelli P, Brundo MV, Copat C (2018b) Trace elements bioaccumulation in liver and fur of Myotis myotis from two caves of the eastern side of Sicily (Italy): a comparison between a control and a polluted area. Environ Pollut Barking Essex 1987(240):273–285. https://doi.org/10.1016/j.envpol.2018.04.133

    Article  CAS  Google Scholar 

  • Ferrante M, Vassallo M, Mazzola A, Brundo MV, Pecoraro R, Grasso A, Copat C (2018c) In vivo exposure of the marine sponge Chondrilla nucula Schmidt, 1862 to cadmium (Cd), copper (Cu) and lead (Pb) and its potential use for bioremediation purposes. Chemosphere 193:1049–1057. https://doi.org/10.1016/j.chemosphere.2017.11.144

    Article  CAS  Google Scholar 

  • Ferrante M, Napoli S, Grasso A, Zuccarello P, Cristaldi A, Copat C (2019) Systematic review of arsenic in fresh seafood from the Mediterranean Sea and European Atlantic coasts: a health risk assessment. Food Chem Toxicol Int J Publ Br Ind Biol Res Assoc 126:322–331. https://doi.org/10.1016/j.fct.2019.01.010

    Article  CAS  Google Scholar 

  • Filippini T, Michalke B, Wise LA, Malagoli C, Malavolti M, Vescovi L, Salvia C, Bargellini A, Sieri S, Krogh V, Ferrante M, Vinceti M (2018) Diet composition and serum levels of selenium species: a cross-sectional study. Food Chem Toxicol Int J Publ Br Ind Biol Res Assoc 115:482–490. https://doi.org/10.1016/j.fct.2018.03.048

    Article  CAS  Google Scholar 

  • Folarin OR, Adaramoye OA, Akanni OO, Olopade JO (2018) Changes in the brain antioxidant profile after chronic vanadium administration in mice. Metab Brain Dis 33:377–385. https://doi.org/10.1007/s11011-017-0070-9

    Article  CAS  Google Scholar 

  • Galan-Chilet I, Tellez-Plaza M, Guallar E, De Marco G, Lopez-Izquierdo R, Gonzalez-Manzano I, Carmen Tormos M, Martin-Nuñez GM, Rojo-Martinez G, Saez GT, Martín-Escudero JC, Redon J, Javier Chaves F (2014) Plasma selenium levels and oxidative stress biomarkers: a gene–environment interaction population-based study. Free Radic Biol Med 74:229–236. https://doi.org/10.1016/j.freeradbiomed.2014.07.005

    Article  CAS  Google Scholar 

  • García-Medina S, Galar-Martínez M, Gómez-Oliván LM, Ruiz-Lara K, Islas-Flores H, Gasca-Pérez E (2017) Relationship between genotoxicity and oxidative stress induced by mercury on common carp (Cyprinus carpio) tissues. Aquat Toxicol Amst Neth 192:207–215. https://doi.org/10.1016/j.aquatox.2017.09.019

    Article  CAS  Google Scholar 

  • Ghafari Farsani H, Binde Doria H, Jamali H, Hasanpour S, Mehdipour N, Rashidiyan G (2017) The protective role of vitamin E on Oreochromis niloticus exposed to ZnONP. Ecotoxicol Environ Saf 145:1–7. https://doi.org/10.1016/j.ecoenv.2017.07.005

    Article  CAS  Google Scholar 

  • Greani S, Lourkisti R, Berti L, Marchand B, Giannettini J, Santini J, Quilichini Y (2017) Effect of chronic arsenic exposure under environmental conditions on bioaccumulation, oxidative stress, and antioxidant enzymatic defenses in wild trout Salmo trutta (Pisces, Teleostei). Ecotoxicol Lond Engl 26:930–941. https://doi.org/10.1007/s10646-017-1822-3

    Article  CAS  Google Scholar 

  • Guo R, Pan L, Ji R (2017) A multi-biomarker approach in scallop Chlamys farreri to assess the impact of contaminants in Qingdao coastal area of China. Ecotoxicol Environ Saf 142:399–409. https://doi.org/10.1016/j.ecoenv.2017.04.043

    Article  CAS  Google Scholar 

  • Hernández RB, Farina M, Espósito BP, Souza-Pinto NC, Barbosa F, Suñol C (2011) Mechanisms of manganese-induced neurotoxicity in primary neuronal cultures: the role of manganese speciation and cell type. Toxicol Sci Off J Soc Toxicol 124:414–423. https://doi.org/10.1093/toxsci/kfr234

    Article  CAS  Google Scholar 

  • Husak VV, Mosiichuk NM, Kubrak OI, Matviishyn TM, Storey JM, Storey KB, Lushchak VI (2018) Acute exposure to copper induces variable intensity of oxidative stress in goldfish tissues. Fish Physiol Biochem 44:841–852. https://doi.org/10.1007/s10695-018-0473-5

    Article  CAS  Google Scholar 

  • Kaya H, Aydın F, Gürkan M, Yılmaz S, Ates M, Demir V, Arslan Z (2015) Effects of zinc oxide nanoparticles on bioaccumulation and oxidative stress in different organs of tilapia (Oreochromis niloticus). Environ Toxicol Pharmacol 40:936–947. https://doi.org/10.1016/j.etap.2015.10.001

    Article  CAS  Google Scholar 

  • Kryndushkin D, Rao VA (2016) Comparative effects of metal-catalyzed oxidizing systems on carbonylation and integrity of therapeutic proteins. Pharm Res 33:526–539. https://doi.org/10.1007/s11095-015-1807-y

    Article  CAS  Google Scholar 

  • LeBlanc G, Buchwalter D (2010) Basics of environmental toxicology. In: Hodgson E (ed) A textbook of modern toxicology (4th edn). Hoboken, pp 531–547

  • Machado C, Zaleski T, Rodrigues E, Carvalho CDS, Cadena SMSC, Gozzi GJ, Krebsbach P, Rios FS, Donatti L (2014) Effect of temperature acclimation on the liver antioxidant defence system of the Antarctic nototheniids Notothenia coriiceps and Notothenia rossii. Comp Biochem Physiol B Biochem Mol Biol 172–173:21–28. https://doi.org/10.1016/j.cbpb.2014.02.003

    Article  CAS  Google Scholar 

  • Mansouri M, Khorasani N, Karbassi A, Riazi B, Panahandeh M (2013) Assessing human risk of contaminants in Anzali Wetland fishes. Interntional J Appl Innov Eng Manag 2:119–126

    Google Scholar 

  • Martínez-Gómez C, Fernández B, Benedicto J, Valdés J, Campillo JA, León VM, Vethaak AD (2012) Health status of red mullets from polluted areas of the Spanish Mediterranean coast, with special reference to Portmán (SE Spain). Mar Environ Res 77:50–59. https://doi.org/10.1016/j.marenvres.2012.02.002

    Article  CAS  Google Scholar 

  • Mazzariol S, Di Guardo G, Petrella A, Marsili L, Fossi CM, Leonzio C, Zizzo N, Vizzini S, Gaspari S, Pavan G, Podestà M, Garibaldi F, Ferrante M, Copat C, Traversa D, Marcer F, Airoldi S, Frantzis A, Quirós YDB, Cozzi B, Fernández A (2011) Sometimes sperm whales (Physeter macrocephalus) cannot find their way back to the high seas: a multidisciplinary study on a mass stranding. PLoS One 6:e19417. https://doi.org/10.1371/journal.pone.0019417

    Article  CAS  Google Scholar 

  • Mazzei V, Longo G, Brundo MV, Copat C, Oliveri Conti G, Ferrante M (2013) Effects of heavy metal accumulation on some reproductive characters in Armadillidium granulatum Brandt (Crustacea, Isopoda, Oniscidea). Ecotoxicol Environ Saf 98:66–73. https://doi.org/10.1016/j.ecoenv.2013.09.023

    Article  CAS  Google Scholar 

  • Mazzei V, Giannetto A, Brundo MV, Maisano M, Ferrante M, Copat C, Mauceri A, Longo G (2015) Metallothioneins and heat shock proteins 70 in Armadillidium vulgare (Isopoda, Oniscidea) exposed to cadmium and lead. Ecotoxicol Environ Saf 116:99–106. https://doi.org/10.1016/j.ecoenv.2015.03.007

    Article  CAS  Google Scholar 

  • Mendes R, Cardoso C, Pestana C (2009) Measurement of malondialdehyde in fish: a comparison study between HPLC methods and the traditional spectrophotometric test. Food Chem 112:1038–1045. https://doi.org/10.1016/j.foodchem.2008.06.052

    Article  CAS  Google Scholar 

  • Mohinuzzaman M, Saadat A, Mostof K, Islam S, Hossain S, Tareq S (2018) Health risk assessment of chromium-accumulated fish and vegetables at Gulshan Lake of Bangladesh: a case study. Pollution 4:459–469

    CAS  Google Scholar 

  • Moreda-Piñeiro J, Moreda-Piñeiro A, Romarís-Hortas V, Domínguez-González R, Alonso-Rodríguez E, López-Mahía P, Muniategui-Lorenzo S, Prada-Rodríguez D, Bermejo-Barrera P (2013) In vitro bioavailability of total selenium and selenium species from seafood. Food Chem 139:872–877. https://doi.org/10.1016/j.foodchem.2013.01.116

    Article  CAS  Google Scholar 

  • Moreno JA, Yeomans EC, Streifel KM, Brattin BL, Taylor RJ, Tjalkens RB (2009) Age-dependent susceptibility to manganese-induced neurological dysfunction. Toxicol Sci Off J Soc Toxicol 112:394–404. https://doi.org/10.1093/toxsci/kfp220

    Article  CAS  Google Scholar 

  • Muñoz S, Méndez L, Dasilva G, Torres JL, Ramos-Romero S, Romeu M, Nogués MR, Medina I (2018) Targeting hepatic protein carbonylation and oxidative stress occurring on diet-induced metabolic diseases through the supplementation with fish oils. Mar Drugs. https://doi.org/10.3390/md16100353

    Article  Google Scholar 

  • Ngwa HA, Ay M, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG (2017) Neurotoxicity of vanadium. Adv Neurobiol 18:287–301. https://doi.org/10.1007/978-3-319-60189-2_14

    Article  Google Scholar 

  • Nicoletti A, Vasta R, Venti V, Mostile G, Lo Fermo S, Patti F, Scillieri R, De Cicco D, Volanti P, Marziolo R, Maimone D, Fiore M, Ferrante M, Zappia M (2016) The epidemiology of amyotrophic lateral sclerosis in the Mount Etna region: a possible pathogenic role of volcanogenic metals. Eur J Neurol 23:964–972. https://doi.org/10.1111/ene.12973

    Article  CAS  Google Scholar 

  • Oymak S, Karadede-Akin H, Dogan N (2009) Heavy metal in tissues of Tor grypus from Atatürk Dam Lake, Euphrates River-Turkey. Biologia (Bratisl.) 69:151–155

    Google Scholar 

  • Pan L, Zhang M, Jin Q, Ji R (2017) Multi-biomarker approach in the scallop Chlamys farreri to assess PAHs pollution in Qingdao coastal areas of China. Environ Sci Process Impacts 19:1387–1403. https://doi.org/10.1039/c7em00186j

    Article  CAS  Google Scholar 

  • Penezić AZ, Jovanović VB, Pavićević ID, Aćimović JM, Mandić LM (2015) HSA carbonylation with methylglyoxal and the binding/release of copper(II) ions. Metallomics 7:1431–1438. https://doi.org/10.1039/C5MT00159E

    Article  CAS  Google Scholar 

  • Penland TN, Grieshaber CA, Kwak TJ, Cope WG, Heise RJ, Sessions FW (2018) Food web contaminant dynamics of a large Atlantic Slope river: implications for common and imperiled species. Sci Total Environ 633:1062–1077. https://doi.org/10.1016/j.scitotenv.2018.03.251

    Article  CAS  Google Scholar 

  • Piazzolla D, Scanu S, Frattarelli FM, Mancini E, Tiralongo F, Brundo MV, Tibullo D, Pecoraro R, Copat C, Ferrante M, Marcelli M (2015) Trace-metal enrichment and pollution in coastal sediments in the Northern Tyrrhenian Sea, Italy. Arch Environ Contam Toxicol 69:470–481. https://doi.org/10.1007/s00244-015-0166-3

    Article  CAS  Google Scholar 

  • Pringault O, Lafabrie C, Avezac M, Bancon-Montigny C, Carre C, Chalghaf M, Delpoux S, Duvivier A, Elbaz-Poulichet F, Gonzalez C, Got P, Leboulanger C, Spinelli S, Sakka Hlaili A, Bouvy M (2016) Consequences of contaminant mixture on the dynamics and functional diversity of bacterioplankton in a southwestern Mediterranean coastal ecosystem. Chemosphere 144:1060–1073. https://doi.org/10.1016/j.chemosphere.2015.09.093

    Article  CAS  Google Scholar 

  • Recknagel RO, Glende EA (2011) Lipid peroxidation: a specific form of cellular injury. Comprehensive physiology. American Cancer Society, Atlanta, pp 591–601. https://doi.org/10.1002/cphy.cp090138

    Chapter  Google Scholar 

  • Rizzo M, Ventrice D, Giannetto F, Cirinnà S, Santagati NA, Procopio A, Mollace V, Muscoli C (2017) Antioxidant activity of oleuropein and semisynthetic acetyl-derivatives determined by measuring malondialdehyde in rat brain. J Pharm Pharmacol 69:1502–1512. https://doi.org/10.1111/jphp.12807

    Article  CAS  Google Scholar 

  • Salvaggio A, Pecoraro R, Scalisi EM, Tibullo D, Lombardo BM, Messina G, Loreto F, Copat C, Ferrante M, Avola R, D’amante G, Genovese C, Raccuia SA, Brundo MV (2017) Morphostructural and immunohistochemical study on the role of metallothionein in the detoxification of heavy metals in Apis mellifera L., 1758. Microsc Res Tech 80:1215–1220. https://doi.org/10.1002/jemt.22919

    Article  CAS  Google Scholar 

  • Salvaggio A, Tiralongo F, Krasakopoulou E, Marmara D, Giovos I, Crupi R, Messina G, Lombardo BM, Marzullo A, Pecoraro R, Scalisi EM, Copat C, Zuccarello P, Ferrante M, Brundo MV (2019) Biomarkers of exposure to chemical contamination in the commercial fish species Lepidopus caudatus (Euphrasen, 1788): a particular focus on plastic additives. Front Physiol 10:905. https://doi.org/10.3389/fphys.2019.00905

    Article  Google Scholar 

  • Sanchez W, Porcher J-M (2009) Fish biomarkers for environmental monitoring within the Water Framework Directive of the European Union. TrAC Trends Anal Chem 28:150–158. https://doi.org/10.1016/j.trac.2008.10.012

    Article  CAS  Google Scholar 

  • Scanu S, Piazzolla D, Frattarelli FM, Mancini E, Tiralongo F, Brundo MV, Tibullo D, Pecoraro R, Copat C, Ferrante M, Marcelli M (2016) Mercury enrichment in sediments of the coastal area of Northern Latium, Italy. Bull Environ Contam Toxicol 96:630–637. https://doi.org/10.1007/s00128-016-1776-9

    Article  CAS  Google Scholar 

  • Sele V, Ørnsrud R, Sloth JJ, Berntssen MHG, Amlund H (2018) Selenium and selenium species in feeds and muscle tissue of Atlantic salmon. J Trace Elem Med Biol 47:124–133. https://doi.org/10.1016/j.jtemb.2018.02.005

    Article  CAS  Google Scholar 

  • Soares SS, Martins H, Duarte RO, Moura JJG, Coucelo J, Gutiérrez-Merino C, Aureliano M (2007) Vanadium distribution, lipid peroxidation and oxidative stress markers upon decavanadate in vivo administration. J Inorg Biochem 101:80–88. https://doi.org/10.1016/j.jinorgbio.2006.08.002

    Article  CAS  Google Scholar 

  • Sunjog K, Kolarević S, Kračun-Kolarević M, Višnjić-Jeftić Ž, Gačić Z, Lenhardt M, Vuković-Gačić B (2019) Seasonal variation in metal concentration in various tissues of the European chub (Squalius cephalus L.). Environ Sci Pollut Res Int 26:9232–9243. https://doi.org/10.1007/s11356-019-04274-3

    Article  CAS  Google Scholar 

  • Talavera EJ, Arcaya JL, Giraldoth D, Suárez J, Bonilla E (1999) Decrease in spontaneous motor activity and in brain lipid peroxidation in manganese and melatonin treated mice. Neurochem Res 24:705–708

    Article  CAS  Google Scholar 

  • Taylor MD, Erikson KM, Dobson AW, Fitsanakis VA, Dorman DC, Aschner M (2006) Effects of inhaled manganese on biomarkers of oxidative stress in the rat brain. Neurotoxicology 27:788–797. https://doi.org/10.1016/j.neuro.2006.05.006

    Article  CAS  Google Scholar 

  • Tigano C, Tomasello B, Pulvirenti V, Ferrito V, Copat C, Carpinteri G, Mollica E, Sciacca S, Renis M (2009) Assessment of environmental stress in Parablennius sanguinolentus (Pallas, 1814) of the Sicilian Ionian coast. Ecotoxicol Environ Saf 72:1278–1286. https://doi.org/10.1016/j.ecoenv.2008.09.028

    Article  CAS  Google Scholar 

  • Tomasello B, Copat C, Pulvirenti V, Ferrito V, Ferrante M, Renis M, Sciacca S, Tigano C (2012) Biochemical and bioaccumulation approaches for investigating marine pollution using Mediterranean rainbow wrasse, Coris julis (Linneaus 1798). Ecotoxicol Environ Saf 86:168–175. https://doi.org/10.1016/j.ecoenv.2012.09.012

    Article  CAS  Google Scholar 

  • Traina A, Bono G, Bonsignore M, Falco F, Giuga M, Quinci EM, Vitale S, Sprovieri M (2019) Heavy metals concentrations in some commercially key species from Sicilian coasts (Mediterranean Sea): potential human health risk estimation. Ecotoxicol Environ Saf 168:466–478. https://doi.org/10.1016/j.ecoenv.2018.10.056

    Article  CAS  Google Scholar 

  • Uysal K, Emre Y, Köse E (2008) The determination of heavy metal accumulation ratios in muscle, skin and gills of some migratory fish species by inductively coupled plasma-optical emission spectrometry (ICP-OES) in Beymelek Lagoon (Antalya/Turkey). Microchem J 90:67–70

    Article  CAS  Google Scholar 

  • van der Oost R, Beyer J, Vermeulen NPE (2003) Fish bioaccumulation and biomarkers in environmental risk assessment: a review. Environ Toxicol Pharmacol 13:57–149

    Article  Google Scholar 

  • Vinceti M, Bottecchi I, Fan A, Finkelstein Y, Mandrioli J (2012) Are environmental exposures to selenium, heavy metals, and pesticides risk factors for amyotrophic lateral sclerosis? Rev Environ Health 27:19–41

    Article  CAS  Google Scholar 

  • Wei K, Yang J (2016) Copper-induced oxidative damage to the prophenoloxidase-activating system in the freshwater crayfish Procambarus clarkii. Fish Shellfish Immunol 52:221–229. https://doi.org/10.1016/j.fsi.2016.03.151

    Article  CAS  Google Scholar 

  • Levine RL, Garland D, Oliver CN, Amici A, Climent I, Lenz A-G, Ahn B-W, Shaltiel S, Stadtman ER (1990) [49] Determination of carbonyl content in oxidatively modified proteins. Methods in enzymology, oxygen radicals in biological systems part B: oxygen radicals and antioxidants. Academic Press, New York, pp 464–478. https://doi.org/10.1016/0076-6879(90)86141-H

    Chapter  Google Scholar 

  • Yan L-J, Forster MJ (2011) Chemical probes for analysis of carbonylated proteins: a review. J. Chromatogr B Anal Technol Biomed Life Sci 879:1308–1315. https://doi.org/10.1016/j.jchromb.2010.08.004

    Article  CAS  Google Scholar 

  • Yin J, Wang A-P, Li W-F, Shi R, Jin H-T, Wei J-F (2018) Time-response characteristic and potential biomarker identification of heavy metal induced toxicity in zebrafish. Fish Shellfish Immunol 72:309–317. https://doi.org/10.1016/j.fsi.2017.10.047

    Article  CAS  Google Scholar 

  • Zuccarello P, Ferrante M, Cristaldi A, Copat C, Grasso A, Sangregorio D, Fiore M, Oliveri Conti G (2019a) Exposure to microplastics (< 10 μm) associated to plastic bottles mineral water consumption: the first quantitative study. Water Res 157:365–371. https://doi.org/10.1016/j.watres.2019.03.091

    Article  CAS  Google Scholar 

  • Zuccarello P, Ferrante M, Cristaldi A, Copat C, Grasso A, Sangregorio D, Fiore M, Oliveri Conti G (2019b) Reply for comment on “exposure to microplastics (< 10 μm) associated to plastic bottles mineral water consumption: the first quantitative study by Zuccarello et al. [Water Research 157 (2019) 365–371]. Water Res. https://doi.org/10.1016/j.watres.2019.115077

    Article  Google Scholar 

Download references

Acknowledgements

University Research Funding (FIR) 2014, University of Catania. Grant Number 9A410A.

Author information

Authors and Affiliations

  1. Department of Medical, Surgery Sciences and Advanced Technologies, G. F. Ingrassia, University of Catania, Catania, Italy

    Chiara Copat, Alfina Grasso, Pietro Zuccarello, Maria Fiore & Margherita Ferrante

  2. Department of Drug Sciences, University of Catania, Catania, Italy

    Milena Rizzo & Agata Zuccaro

  3. Department of Civil and Environmental Engineering (DICA), University of Catania, Catania, Italy

    Giuseppe Mancini

Authors
  1. Chiara Copat
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Milena Rizzo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Agata Zuccaro
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Alfina Grasso
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Pietro Zuccarello
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Maria Fiore
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Giuseppe Mancini
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Margherita Ferrante
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Chiara Copat.

Ethics declarations

Conflict of interest

All authors declare that they have no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Copat, C., Rizzo, M., Zuccaro, A. et al. Metals/Metalloids and Oxidative Status Markers in Saltwater Fish from the Ionic Coast of Sicily, Mediterranean Sea. Int J Environ Res 14, 15–27 (2020). https://doi.org/10.1007/s41742-019-00237-1

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s41742-019-00237-1

Keywords

Search

Navigation