Cell Metabolism
Volume 31, Issue 2, 4 February 2020, Pages 213-214
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Alcohol Makes Its Epigenetic Marks

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The toxic effects of alcohol consumption are dependent upon its metabolism in the liver to downstream metabolites: acetaldehyde, acetate, and acetyl-CoA. Recently, in Nature, Mews et al. (2019) have discovered that acetyl-CoA derived from alcohol plays an important epigenetic role in regulating ethanol’s effects on the brain through histone acetylation.

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