Skip to main content
SpringerLink
Log in

Arylbenzofuran Lignans from the Seeds of Arctium lappa and Their Bioactivity

  • Published:
Chemistry of Natural Compounds Aims and scope

Two new (1 and 2) and two known arylbenzofuran lignans (3 and 4) were isolated from the seeds of Arctium lappa. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1–4 were evaluated for their anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity. The results revealed that compound 3 showed good inhibition with IZD of 13.5 ± 1.5 mm), and compounds 1, 2, and 4 showed weak inhibition with IZD of 9.6 ± 1.0, 11.6 ± 1.2, and 10.8 ± 1.2 mm, respectively. Compounds 1–4 were also tested for the antioxidant activity, and they show good antioxidant activity with an IC50 values of 4.38, 4.22, 3.96, and 4.15 μg/mL, respectively.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.

Similar content being viewed by others

References

  1. R. Lin and Z. Shi, Flora of China, Vol. 78, Beijing, Chinese Science Press, 1987, p. 58.

    Google Scholar 

  2. T. Ozawa, J. Pharm. Soc. Jpn., 16, 551 (1952).

    Article  Google Scholar 

  3. M. Abe, K. Ueno, Y. Ishiguro, T. Omori, S. Onodera, and N. Shiomi, J. Appl. Glycosci., 56, 239 (2009).

    Article  CAS  Google Scholar 

  4. Y. S. Chan, L. N. Cheng, J. H. Wu, E. Chan, Y. W. Kwan, S. M. Lee, G. P., Leung, P. H. Yu, and S. C. Wan, Inflammopharmacology, 19, 245 (2011).

  5. S. H. Wu, J. H. Du, N. B. Abula, Y. H. Yu, and J. H. Han, Chin. J. Trad. Med. Pharm., 32, 3093 (2017).

    Google Scholar 

  6. T. Matsumoto, K. Hosononishiyama, and H. Yamada, Planta Med., 72, 276 (2005).

    Article  Google Scholar 

  7. Y. N. Yang, X. Y. Huang, Z. M. Feng, J. S. Jiang, and P. C. Zhang, J. Agric. Food Chem., 63, 7958 (2015).

    Article  CAS  Google Scholar 

  8. C. Lou, Z. Zhu, Y. Zhao, R. Zhu, and H. Zhao, Oncol. Rep., 37, 179 (2017).

    Article  Google Scholar 

  9. J. M. Yoo, J. H. Yang, H. J. Yang, W. K. Cho, and J. Y. Ma, Int. J. Mol. Med., 37, 501 (2016).

    Article  CAS  Google Scholar 

  10. I. Iochkova, Dokl. Bolg. Akad. Nauk, 42, 43 (1989).

    CAS  Google Scholar 

  11. X. W. Jiang, J. P. Bai, Q. Zhang, X. L. Hu, X. Tian, J. Zhu, J. Liu, W. H. Meng, and Q. C. Zhao, Phytochem. Lett., 15, 159 (2016).

    Article  CAS  Google Scholar 

  12. B. Hou, W. Wang, H. Gao, S. Cai, and C. Wang, J. Int. Med. Res., 46, 158 (2018).

    Article  Google Scholar 

  13. Z. Zheng, X. Wang, P. Liu, M. Li, H. Dong, and X. Qiao, Molecules, 23, E429 (2018).

    Article  Google Scholar 

  14. A. R. C. Souza, A. R. Guedesa, J. M. F. Rodriguez, M. C. M. Bombardelli, and M. L. Corazza, J. Supercrit. Fluids, 140, 137 (2018).

    Article  Google Scholar 

  15. Z. Lou, C. Li, X. Kou, F. Yu, H. Wang, G. M. Smith, and S. Zhu, J. Food. Protect., 79, 1404 (2016).

    Article  CAS  Google Scholar 

  16. M. Saleem, H. J. Kim, M. S. Ali, and Y. S. Lee, Nat. Prod. Rep., 22, 696 (2005).

    Article  CAS  Google Scholar 

  17. K. Sowndhararajan, P. Deepa, M. Kim, S. J. Park, and S. Kim, Biomed. Pharmacother., 97, 958 (2018).

    Article  CAS  Google Scholar 

  18. H. Y. Ma, L. Zhou, W. Dong, Y. D. Wang, K. Zhou, Y. Yang, H. H. Xing, M. Zhou, Y. Q. Ye, and Q. F. Hu, Chin. Trad. Herb. Drugs, 47, 2975 (2016).

    Google Scholar 

  19. S. Y. Tang, J. L. Shi, C. B. Liu, F. M. Zhang, N. J. Xiang, X. Liu, Y. K. Chen, J. H. You, Q. P Shen, M. M. Miao, Z. H. Liu, and G. Y. Yang, Phytochem. Lett., 19, 60 (2017).

  20. Q. F. Hu, B. Zhou, X. M. Gao, L. Y. Yang, L. D. Shu, Y. Q. Shen, G. P. Li, C. T. Che, and G. Y, Yang, J. Nat. Prod., 75, 1909 (2012).

    Article  CAS  Google Scholar 

  21. X. Liu, W. S. Kong, P. Li, J. Li, L. Ye, Y. Q. Gen, C. Q. Jiang, Y. P. Li, G. X. Rao, M. Zhou, G. Y. Yang, X. M. Li, and Q. F. Hu, Chem. Nat. Compd., 54, 1052 (2018).

    Article  CAS  Google Scholar 

  22. Clinical and Laboratory Standards Institute, Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically, Approved Standard, Vol. 32, Clinical and Laboratory Standards Institute, Wayne, Pa, USA, 9th edition, 2012.

  23. E. Tripoli, M. Guardia, S. Giammanco, D. Majo, and M. Giammanco, Food Chem., 104, 466 (2007).

    Article  CAS  Google Scholar 

Download references

Acknowledgment

This work was financially supported by the National Natural Science Foundation of China (No. 21562044), the Joint Foundation of Yunnan Province-Kunming Medical University [2017FE468(-186)], and the Research Foundation of China Tobacco Yunnan Industrial Co., Ltd. (No. 2019SC04).

Author information

Authors and Affiliations

  1. Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industrial Co., Ltd., Kunming, 650231, China

    Qi-Li Mi, Meng-Jie Liang, Qian Gao, Chun-Man Song, Hai-Tao Huang, Yong Xu, Jin Wang, Guang-Yu Yang, Zhang-Yu Chen & Xue-Mei Li

  2. School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, 650500, China

    Qi-Li Mi, Meng-Jie Liang, Liang Deng & Ya-Dong Guo

Authors
  1. Qi-Li Mi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Meng-Jie Liang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Qian Gao
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Chun-Man Song
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hai-Tao Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yong Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Jin Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Liang Deng
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Guang-Yu Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Ya-Dong Guo
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Zhang-Yu Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Xue-Mei Li
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Zhang-Yu Chen or Xue-Mei Li.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2020, pp. 52–55.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mi, QL., Liang, MJ., Gao, Q. et al. Arylbenzofuran Lignans from the Seeds of Arctium lappa and Their Bioactivity. Chem Nat Compd 56, 53–57 (2020). https://doi.org/10.1007/s10600-020-02942-2

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10600-020-02942-2

Keywords

Search

Navigation