Original articleClinical endoscopyFamily history of colorectal cancer and prevalence of advanced colorectal neoplasia in asymptomatic screened populations in different age groups
Section snippets
Study setting and design
This study was approved by the Ethics Committee for Clinical Research of the National Cancer Center in Tokyo, Japan. The study was conducted using the database of screened individuals at the Cancer Screening Center of the National Cancer Center in Tokyo, Japan. The Cancer Screening Center was founded in February 2004 to prospectively evaluate cancer screening programs.19,20 Since then, opportunistic cancer screening has been provided for asymptomatic average-risk individuals; total colonoscopy
Baseline characteristics of screened individuals aged 40 to 54 and 55 to 69 years
A flowchart of the data used in this study is shown in Figure 1. Data from 4884 asymptomatic screened individuals were used. None of these individuals had inflammatory bowel disease, a history of bowel resection, or an FH of hereditary CRC.
Of 2263 screened individuals aged 40 to 54 years, 249 (11.0%) had FDRs with CRC. No significant difference in the baseline characteristics was observed between these 249 individuals with affected FDRs and the remaining 2014 individuals without affected FDRs (
Discussion
The present study demonstrated the clinical significance of an FH of CRC in FDRs as a risk factor for ACN in younger asymptomatic screened individuals aged 40 to 54 years. In contrast, a positive FH had a weaker impact on relatively older screened individuals aged 55 to 69 years except those with 2 affected FDRs. Under the current circumstances in which no consensus has been reached regarding the relationship between the age of screened individuals and the influence of FH, the findings from our
Acknowledgments
We thank H. Nikki March, PhD, and Angela Morben, DVM, ELS, from Edanz Group (www.edanzediting.com/ac) and Editage (www.editage.com) for editing a draft of this manuscript.
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DISCLOSURE: All authors disclosed no financial relationships. Research support for this study was provided by JSPS KAKENHI (grant no. 17K15978) (M.S.) and the National Cancer Center Research and Development Fund (30-A-16) (M.S., T.M.).
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