Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

STRUCTURAL BIOLOGY

Structure of an Arc-ane virus-like capsid

Recent findings unveil a viral-like mechanism for the transmission of synaptic plasticity signals involving the activity-regulated cytoskeleton-associated protein (Arc). Arc forms capsid-like particles that package RNA and are transported across synapses. Here Erlendsson et al. present a high-resolution structural representation of Arc capsids, enabling deeper analysis of their function.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Viral-like transfer of Arc across the NMJ.

References

  1. Zhang, W. et al. Neuron 86, 490–500 (2015).

    Article  CAS  Google Scholar 

  2. Ashley, J. et al. Cell 172, 262–274.e11 (2018).

    Article  CAS  Google Scholar 

  3. Pastuzyn, E. D. et al. Cell 172, 275–288.e18 (2018).

    Article  CAS  Google Scholar 

  4. Campillos, M., Doerks, T., Shah, P. K. & Bork, P. Trends Genet. 22, 585–589 (2006).

    Article  CAS  Google Scholar 

  5. Abrusán, G., Szilágyi, A., Zhang, Y. & Papp, B. Nucleic Acids Res. 41, 3190–3200 (2013).

    Article  Google Scholar 

  6. Nikolaienko, O., Patil, S., Eriksen, M. S. & Bramham, C. R. Semin. Cell Dev. Biol. 77, 33–42 (2018).

    Article  CAS  Google Scholar 

  7. Myrum, C. et al. Biochem. J. 468, 145–158 (2015).

    Article  CAS  Google Scholar 

  8. Erlendsson, S. et al. Nat. Neurosci. https://doi.org/10.1038/s41593-019-0569-y (2020).

  9. Siu, Y. L. et al. J. Virol. 82, 11318–11330 (2008).

    Article  CAS  Google Scholar 

  10. Conley, M. J. & Bhella, D. Biophys. Rev. 11, 603–609 (2019).

    Article  CAS  Google Scholar 

  11. Cui, J., Schlub, T. E. & Holmes, E. C. J. Virol. 88, 6403–6410 (2014).

    Article  CAS  Google Scholar 

  12. Mattaliano, M. D., Montana, E. S., Parisky, K. M., Littleton, J. T. & Griffith, L. C. Mol. Cell Neurosci. 36, 211–221 (2007).

    Article  CAS  Google Scholar 

  13. Rogerson, T. et al. Nat. Rev. Neurosci. 15, 157–169 (2014).

    Article  CAS  Google Scholar 

  14. Chowdhury, S. et al. Neuron 52, 445–459 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Vivian Budnik.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Budnik, V., Thomson, T. Structure of an Arc-ane virus-like capsid. Nat Neurosci 23, 153–154 (2020). https://doi.org/10.1038/s41593-019-0580-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41593-019-0580-3

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing