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COPD: Original ResearchAssociations Among 25-Hydroxyvitamin D Levels, Lung Function, and Exacerbation Outcomes in COPD: An Analysis of the SPIROMICS Cohort
Section snippets
Study Participants
SPIROMICS is a multicenter, observational, prospective, cohort study that includes current or former smokers (≥ 20 pack-years), with or without chronic airflow obstruction, between the ages of 40 and 80 years, and nonsmoking control subjects recruited from 12 clinical centers (n = 2,974).24,25 Participants included in this analysis had spirometry-confirmed COPD (FEV1/FVC < 0.70) and available baseline clinical data (n = 1,609) (Fig 1). Institutional review boards at each center approved
Cohort Characteristics
There were 1,609 participants in the analytical cohort (Table 1). Participants had a mean age of 65 years, 42% were female, and 14% were black. Severe COPD (Global Initiative for Chronic Obstructive Lung Disease [GOLD] stage III-IV) was present in 34% of participants, and 31% reported one or more AECOPD in the year before enrollment. All participants had 25-OH-vitamin D levels above the limit of detection (> 3.7 ng/mL). The median vitamin D level in the cohort was 28.9 ng/mL (quartile
Discussion
This study presents the relationship between 25-OH-vitamin D levels and COPD outcomes among 1,609 participants in the SPIROMICS cohort. VDD was seen in 21% of the study cohort and was associated with black race, younger age, and current smoking. VDD was independently associated with lower FEV1 at baseline, a greater rate of lung function decrement after 1 year, and experiencing AECOPD in the year before study enrollment. These findings demonstrate the association between VDD and COPD outcomes,
Conclusion
We have observed VDD in approximately one of five participants with COPD in a multicenter cohort. Active smokers, blacks, and younger participants were more likely to have VDD. Lower 25-OH-vitamin D levels are independently associated with lower baseline lung function as well as greater odds of an AECOPD in the year before enrollment. VDD was associated with a greater rate of lung function decline over 1 year. These findings describe potential adverse effects of VDD on lung function decline in
Acknowledgments
Author contributions: R. M. B. had access to the data and is the guarantor for the content of the manuscript including data and analysis. R. M. B. and M. B. D. had full access to the data and take responsibility for the integrity of the data and accuracy of analysis presented herein. M. B. D. and R. M. B. contributed substantially to the design of the study, data interpretation, and drafting of the manuscript. A. S. C., M. B. D., and R. M. B. contributed to data analysis. D. C., E. A. H., A. P.
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2021, Respiratory MedicineCitation Excerpt :The ubiquitous distribution of vitamin D (25-hydroxyvitamin D [25(OH)D]) receptor suggests that 25(OH)D plays various roles unrelated to calcium homeostasis and bone metabolism in our body [1]. For example, an association between serum 25(OH)D level (SVDL) and lung function decline (LFD) in subjects with established respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD) [2,3]. So far, a few studies have searched possible associations between SVDL and LFD in healthy individuals [4–6].
FUNDING/SUPPORT: R. M. B. has received support from the National Institutes of Health, National Heart, Lung, and Blood Institute (NIH-NHLBI) [Grant F32HL143867-01] related to this work. M. B. D. has received support from the NIH-NHLBI [Grant R01HL125432-01A1] related to this work. For SPIROMICS funding, see Acknowledgments.
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Collaborators from the SPIROMICS study are listed in the Acknowledgments.