ReportPrevalence of Maculopathy Associated with Long-Term Pentosan Polysulfate Therapy
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2022, American Journal of OphthalmologyRedefining the Spectrum of Pentosan Polysulfate Retinopathy: Multimodal Imaging Findings from a Cross-Sectional Screening Study
2022, Ophthalmology RetinaCitation Excerpt :Others have described lower thresholds for diagnosing toxicity, with the report of a case of possible macular toxicity at a dose < 500 g and 7 affected patients with doses between 500 and 1000g.4 The odds ratio of developing toxicity was 2.95 in a patient group with cumulative doses between 500 and 999 g (prevalence of PPS toxicity of 11%) and 4.91 in a patient group taking > 1500 g (prevalence of PPS toxicity of 42%).5 Based on these results, it has been recommended that patients taking cumulative dosages > 500 g receive annual imaging.13
Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
HUMAN SUBJECTS: Human subjects were not included in this study. This study is based on review of medical records. The human ethics committees at the Kaiser Permanente IRB approved the study. All research adhered to the tenets of the Declaration of Helsinki. This is a retrospective study using de-identified subject details. Informed consent was not obtained.
No animal subjects were used in this study.
Author Contributions:
Conception and design: Vora, Patel, Melles
Data collection: Vora, Patel, Melles
Analysis and interpretation: Vora, Patel, Melles
Obtained funding: Not applicable
Overall responsibility: Vora, Patel, Melles