Rhinitis, sinusitis, and ocular allergySensitization to grass pollen allergen molecules in a birth cohort—natural Phl p 4 as an early indicator of grass pollen allergy
Section snippets
The BAMSE cohort
We used data from the population-based BAMSE (Barn/Children, Allergy, Milieu, Stockholm, Epidemiology) birth cohort. The details of the study have been published previously.15 In brief, the cohort consists of 4089 children recruited shortly after birth, when baseline data were obtained; parental questionnaires on symptoms of allergy-related disorders were used repeatedly thereafter to obtain data until the children were 16 years old. The response rate at the latest follow up at the age of 16
Study population
Comparison of baseline characteristics between the study population (N = 763) and the original cohort of 4089 children revealed no major differences (Table E1, Online Repository).
IgE reactivity from childhood to adolescence
Sensitization to any Phl p molecule increased with increasing age (Fig 1). Among the molecules analyzed, the most prevalent sensitizing allergen molecule was Phl p 1, irrespective of age (Fig 1) (6.6% at the age of 4 years, 22.8% at the age of 8 years, and 31.2% at the age of 16 years), followed in order by Phl p 4
Discussion
Here we used a molecular allergen approach to detect grass pollen sensitization and to predict, early in life, symptoms up to adolescence in the population-based BAMSE birth cohort. The results revealed that grass pollen sensitization was significantly more prevalent when detected with allergen molecules than with timothy extract alone. At 4 years of age, the majority of the sensitized children were still asymptomatic and the probability of later symptoms increased with increasing number of
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Phl p 4: An early indicator of grass pollen allergy?
2020, Journal of Allergy and Clinical ImmunologyIgE to cross-reactive carbohydrate determinants: Origins, functions, and confounding role in nPhl p 4-IgE assays
2020, Journal of Allergy and Clinical Immunology
Supported by the Acta Oto-Laryngologica Foundation, the Stockholm County Council, the Swedish Asthma and Allergy Research Foundation, the Swedish Heart-Lung Foundation, the Swedish Research Council, and the European Commissionś Seventh Framework 29 Program MeDALL under grant agreement No. 261357.
Disclosure of potential conflict of interest: M. Westman reports personal fees from ALK and Mylan outside the submitted work. C. Lupinek reports personal fees from Thermo Fisher Scientific outside the submitted work. I. Mittermann reports grants from the Austrian Science Fund outside the submitted work. E. Melén reports personal fees from Thermo Fisher Scientific and Novartis outside the submitted work. J. Bousquet reports personal fees from Chiesi, Cipla, Hikma, Menarini, Mundipharma, Mylan, Novartis, Purina, Sanofi-Aventis, Takeda, Teva, and Uriach and shares from KYomed-Innov outside the submitted work. R. Valenta reports grants from the Austrian Science Fund and grants and personal fees from Viravaxx outside the submitted work. M. van Hage reports personal fees from Biomay AG, Hycor Biomedical LLC, Thermo Fisher Scientific, and ALK outside the submitted work. The rest of the authors declare that they have no relevant conflicts of interest.