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Micro or nano: Evaluation of biosafety and biopotency of magnesium metal organic framework-74 with different particle sizes

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Abstract

In recent years, various particulate materials have played important roles in medical applications. However, nano- and micron-sized particles of the same material could exhibit distinct properties due to different particle sizes. This finding provided a simple and effective way to improve the biological applications of particulate materials. Therefore, as a highly promising member, the effect of the particle size change of the magnesium metal organic framework-74 (Mg-MOF74) was well worth evaluating. Here we firstly assessed the in vitro and in vivo toxicity of micron/nanoscale Mg-MOF74 (m-Mg-MOF74/n-Mg-MOF74) in detail. Our in vitro study revealed that compared to micron-sized subjects, n-Mg-MOF74 provided a wider range of safe concentrations. Furthermore, both micron/nanoscale Mg-MOF74 showed good biocompatibility and allowed all the rats under the treatment to survive through the expected experimental periods, with n-Mg-MOF74 still showing lower cardiotoxicity. These advantages of nanoscale Mg-MOF74 might benefit from its sustainable and balanced release of Mg2+ both inside and outside the cells. Based on the biosafety evaluation, advanced bio-functional assessments of m/n-Mg-MOF74 including early osteogenesis and angiogenesis were also performed. Similarly, the suitable dose groups of n-Mg-MOF74 achieved optimal early osteogenic promotion and angiogenic stimulation effects. Overall, our combined data delineated the toxicity and biological behaviors of Mg-MOF74 of different scales, and suggested nanoscale Mg-MOF74 as a better choice for future applications. This result revealed that particle size reduction might be a viable strategy to improve and expand medical applications of MOFs or other particulate materials.

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Acknowledgements

This study was supported by the National Natural Science Foundation of China (Nos. 8160161 381771122 81970985, and 81970984), Key research program of Sichuan Science and technology Department (No. 2018SZ0037).

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  1. Zhou Zhu, Shaokang Jiang, and Yanhua Liu contributed equally to this work.

Authors and Affiliations

  1. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 61004, China

    Zhou Zhu, Shaokang Jiang, Yanhua Liu, Xiaomeng Gao, Shanshan Hu, Xin Zhang, Qianbing Wan, Jian Wang & Xibo Pei

  2. College of Chemistry, Sichuan University, Chengdu, 610064, China

    Chao Huang

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  1. Zhou Zhu
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Correspondence to Jian Wang or Xibo Pei.

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Micro or nano: Evaluation of biosafety and biopotency of magnesium metal organic framework-74 with different particle sizes

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Zhu, Z., Jiang, S., Liu, Y. et al. Micro or nano: Evaluation of biosafety and biopotency of magnesium metal organic framework-74 with different particle sizes. Nano Res. 13, 511–526 (2020). https://doi.org/10.1007/s12274-020-2642-y

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