Synergistic effects of S-alkenylmercaptocysteine (CySSR) species derived from Allium tissue and selenium on inducing apoptosis in ER− breast cancer cells
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Graphical abstract
Keywords
Apoptosis
Synergism
S-alkenylmercaptocysteine
Sodium selenite
Allium
Abbreviations
CySSR
cysteine-mixed disulfide conjugate
CySSA
S-allylmercaptocysteine
CySSPe
S-1-propenylmercaptocysteine
CySH
cysteine
CySSCy
cystine
GSH
glutathione (reduced)
Se
sodium selenite
GSK
glycogen synthase kinase
JNK
c-Jun NH2-terminal kinase
MTT
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide
DTNB
5,5′-dithiobis(2-nitrobenzoate)
ROS
reactive oxygen species
SSZ
sulfasalazine
xC-
cystine/glutamate antiporter
ER
estrogen receptor
OSC
organosulfur compounds
ACSO
S-alk(en)yl-l-cysteine sulfoxides
IC50
the half maximal inhibitory concentration
Akt
protein kinase B
FITC
fluorescein isothiocyanate
PI
propidium iodide
Bax
Bcl-2-associated X protein
Bak
Bcl-2 homologous antagonist killer
H2Se
hydrogen selenide
RSH
conjugate thiols
Cited by (0)
- 1
Present address: Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
- 2
Present address: Department of Pharmacy Practice, University of Illinois at Chicago College of Pharmacy, Chicago IL, 60612, USA.
© 2020 The Authors. Published by Elsevier Ltd.