N-Oxide polymer–cupric ion nanogels potentiate disulfiram for cancer therapy

Yin Zhong; Rui Sun; Yu Geng; Quan Zhou; Ying Piao; Tao Xie; Ruhong Zhou; Youqing Shen

doi:10.1039/C9BM01841G

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N-Oxide polymer–cupric ion nanogels potentiate disulfiram for cancer therapy†

Yin Zhong,‡^a Rui Sun,‡^a Yu Geng,^a Quan Zhou,^a Ying Piao,^a Tao Xie,

^a Ruhong Zhou^b and Youqing Shen

*^a

Author affiliations

* Corresponding authors

^a College of Chemical and Biological Engineering, Hangzhou, China
E-mail: shenyq@zju.edu.cn

^b Institute of Quantitative Biology and Department of Physics, Zhejiang University, Hangzhou, China
E-mail: shenyq@zju.edu.cn

Abstract

Disulfiram (DSF) exerts potent anticancer activity via the formation of chelates with copper or zinc ions in tumor tissues, but the low abundance of these ions in the tumor cannot sustain its antitumor activity. Herein, we show that a zwitterionic water-soluble N-oxide polymer, poly[2-(N-oxide-N,N-dimethylamino)ethyl methacrylate] (OPDMA), can complex cupric ions and form nanogels (OPDMA/Cu), which efficiently deliver copper ions to tumor tissue to potentiate DSF significantly for effective antitumor therapy.

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Article information

DOI: https://doi.org/10.1039/C9BM01841G
Article type: Paper
Submitted: 13 Nov 2019
Accepted: 13 Jan 2020
First published: 14 Jan 2020

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Biomater. Sci., 2020,8, 1726-1733

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N-Oxide polymer–cupric ion nanogels potentiate disulfiram for cancer therapy

Y. Zhong, R. Sun, Y. Geng, Q. Zhou, Y. Piao, T. Xie, R. Zhou and Y. Shen, Biomater. Sci., 2020, 8, 1726 DOI: 10.1039/C9BM01841G

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Biomaterials Science

N-Oxide polymer–cupric ion nanogels potentiate disulfiram for cancer therapy†

Abstract

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N-Oxide polymer–cupric ion nanogels potentiate disulfiram for cancer therapy

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