Trends in Immunology
SpotlightACLY-matizing Macrophages to Histone Modification during Immunometabolic Reprogramming
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Acknowledgments
This work was supported by funding from the Wellcome Trust, Irish Research Council, and the European Research Council.
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Cited by (9)
Extracellular citrate serves as a DAMP to activate macrophages and promote LPS-induced lung injury in mice
2021, International ImmunopharmacologyCitation Excerpt :Cytosol citrate is cleaved by ATP citrate lyase (ACLY) into acetyl-CoA and OA [14]. Acetyl-CoA is an essential precursor for histone acetylation [15]. An increasing body of evidence suggests that histone acetylation is involved in the activation of NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome [16,17].
Nuclear-translocation of ACLY induced by obesity-related factors enhances pyrimidine metabolism through regulating histone acetylation in endometrial cancer
2021, Cancer LettersCitation Excerpt :However, the understanding of the lipid metabolism distribution in EC and how the related lipid metabolism works remain poorly understood. ATP-citrate lyase (ACLY), an enzyme that catalyzes ATP-dependent citrate cleavage to produce acetyl-CoA, is a pivotal nucleocytoplasmic metabolic enzyme since it interconnects aberrant glucose and lipid metabolism [50]. ACLY can mediate various fundamental cellular processes, including membrane composition, signal transduction, epigenetic regulation and therapy response by catalyzing acetyl-CoA production, all of which are notable processes of tumor cells in cell survival, proliferation and metastasis [48,53].
Metabolic adaptations of cells at the vascular-immune interface during atherosclerosis
2021, Molecular Aspects of MedicineCitation Excerpt :Similar to statins, treatment with bempedoic acid reduces CRP levels (Laufs et al., 2019; Ruscica et al., 2020), thus suggesting that the immunomodulatory effect could depend on the inhibition of cholesterol biosynthesis in the liver and the reduction of lipoprotein burden. ACLY has been recently shown to be critical also in contributing the acetyl-CoA pool required for histone acetylation and the regulation of TLR-driven gene expression after LPS stimulation (Lauterbach et al., 2019; Williams and O'Neill, 2020). This implies that approaches able to target ACLY specifically in macrophages in the atherosclerotic plaque could reduce their activation.
Angiotensin-(1-7) Modulates the Warburg Effect to Alleviate Inflammation in LPS-Induced Macrophages and Septic Mice
2024, Journal of Inflammation ResearchIdentifying Oxidized Lipid Metabolism-Related LncRNAs as Prognostic Biomarkers of Head and Neck Squamous Cell Carcinoma
2023, Journal of Personalized MedicineMetabolic reprogramming and epigenetic modifications on the path to cancer
2022, Protein and Cell