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Rescue stenting versus medical care alone in refractory large vessel occlusions: a systematic review and meta-analysis

  • Interventional Neuroradiology
  • Published:
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Abstract

Purpose

Mechanical thrombectomy (MT) failure is associated with very poor prognosis. Permanent intracranial stenting (PIS) may be useful in such refractory occlusions. However, this strategy requires an aggressive antithrombotic regimen that may be harmful in extended strokes. The aim of this study was to compare clinical outcomes between patients with refractory acute large vessel occlusions (LVOs) treated by PIS versus patients for whom the procedure was stopped without recanalization.

Methods

We conducted a systematic review by searching for articles in PubMed, the Cochrane Library, and ClinicalTrials.gov from January 2015 to September 2019. Two reviewers independently selected studies comparing PIS after failed MT in addition to usual care versus usual care only. A comparative meta-analysis was performed using random-effects models to estimate odds ratios of favorable clinical outcome at 90 days, defined as a modified Rankin scale 0–2, mortality and symptomatic intracranial hemorrhage (SICH).

Results

Four comparative studies were included for a total of 352 patients: 149 in the PIS group versus 203 in the control group. PIS was associated with significantly higher rates of 90-day favorable clinical outcome (odds ratio [OR], 2.87 [95% confidence interval (95% CI), 1.77–4.66]; p < 0.001; I2, 0%) and lower mortality (OR, 0.39 [0.16–0.93]; p = 0.03; I2, 43%), whereas SICH rates did not significantly differ (OR, 0.68 [0.37–1.27]; p = 0.23; I2, 0%).

Conclusion

From observational study results, attempting PIS after failed MT seems to improve clinical outcomes without increasing the risk of intracranial bleeding. Randomized trials are needed to confirm these results.

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Authors and Affiliations

  1. Department of Interventional Neuroradiology, Sorbonne University, AP-HP, Pitié Salpêtrière - Charles Foix Hospital, 47-83 Boulevard de l’Hôpital, F75013, Paris, France

    Kévin Premat, Stéphanie Lenck, Eimad Shotar, Nader Sourour & Frédéric Clarençon

  2. Departement of Biostatistics, Sorbonne University, INSERM, Pierre Louis Institute of Epidemiology and Public Health, AP-HP, Pitié Salpêtrière - Charles Foix Hospital, Public Health and Medical Information, F75013, Paris, France

    Agnes Dechartres

  3. Departement of Vascular Neurology, Sorbonne University, AP-HP, Pitié Salpêtrière - Charles Foix Hospital, F75013, Paris, France

    Raphaël Le Bouc & Yves Samson

  4. Department of Anesthesiology and Critical Care, Sorbonne University, AP-HP, Pitié Salpêtrière - Charles Foix Hospital, F75013, Paris, France

    Vincent Degos

  5. Departement of Vascular Neurology, Sorbonne University, AP-HP, Saint Antoine Hospital, F75012, Paris, France

    Sonia Alamowitch

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  1. Kévin Premat
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  2. Agnes Dechartres
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Correspondence to Kévin Premat.

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Conflict of Interest

NS reports a conflict of interest with Medtronic, Balt Extrusion, Microvention (consultant) and Stock/Stock Options: Medina. FC reports a conflict of interest with Medtronic, Guerbet, Balt Extrusion (payment for readings), and Codman Neurovascular (core lab).

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Premat, K., Dechartres, A., Lenck, S. et al. Rescue stenting versus medical care alone in refractory large vessel occlusions: a systematic review and meta-analysis. Neuroradiology 62, 629–637 (2020). https://doi.org/10.1007/s00234-020-02360-9

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