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d-ribose and pathogenesis of Alzheimer’s disease

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Abstract

It is estimated that the global prevalence of dementia will rise as high as 24 million and predicted to be double in every 20 years which is attributed to the fact that the ageing population is increasing and so more individuals are at risk of developing neurodegenerative diseases like Alzheimer’s. Many scientists favored glycation of proteins such as tau, amyloid beta (Aβ) etc. as one of the important risk factor in Alzheimer’s disease (AD). Since, d-ribose shows highest glycation ability among other sugars hence, produces advanced glycation end products (AGEs) rapidly. However, there are several other mechanisms suggested by researchers through which d-ribose may cause cognitive impairments. There is a concern related to diabetic patients since they also suffer from d-ribose metabolism, may be more prone to AD risk. Thus, it is imperative that the pathogenesis and the pathways involved in AD progression are explored in the light of ribosylation and AGEs formation for identifying suitable diagnostics marker for early diagnosis or finding promising therapeutic outcomes.

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adapted from with some modifications [89])

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Acknowledgements

The authors are thankful to the Chairperson of Department of Biochemistry, Faculty of Medicine, Aligarh Muslim University, Aligarh.

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  1. Aquatic Toxicology Research Laboratory, Department of Zoology, Aligarh Muslim University, Aligarh, U.P., India

    Mehjbeen Javed

  2. Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, U.P., India

    Md. Irshad Ahmad

  3. Department of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India

    Md. Irshad Ahmad

  4. Department of Chemistry, Aligarh Muslim University, Aligarh, U.P., India

    Hina Javed

  5. Department of Biochemistry, Faculty of Medicine, Aligarh Muslim University, Aligarh, U.P., India

    Sufia Naseem

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MJ, MIA and HJ have equal contributions. SN guided, conceptualized and provided intellectual input and revise the final draft of the manuscript.

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Javed, M., Ahmad, M.I., Javed, H. et al. d-ribose and pathogenesis of Alzheimer’s disease. Mol Biol Rep 47, 2289–2299 (2020). https://doi.org/10.1007/s11033-020-05243-7

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