One-step in situ synthesis of nano silver-hydrotalcite coating for enhanced antibacterial and degradation property of magnesium alloys
Introduction
Magnesium and its alloys have been greatly paid attention as a hot spot for biomedical fields because of the advantages such as low density, proper elastic modulus, bio-degradation and excellent biocompatibility [1]. However, its inferior property of corrosion resistance, one prominent problem, has always limited the extensive application especially for clinic bone implants. Surface modification by ceramic, an effective method for surface modification of magnesium alloys, can significantly improve its corrosion resistance, biocompatibility and functionality without affecting the bulk properties [2]. Particularly, Layered Double Hydroxide (LDH), one type of ceramic coating with interlayer structure, is of significant capability to improve and enhance the corrosion resistance of magnesium alloys through the presence of anions and impacting corroding process of matrix metal [3], [4]. It has also been reported that the LDH was with various functions, such as drug delivery carrier [5], bone repair materials [6] and so forth.
On the other hand, the postoperative infection of implants has always been one of the urgent problems to be solved for clinical orthopedic surgery [7]. It has been reported that the postoperative infection rate of orthopaedic prosthesis implants can reach up to 4% [8], and that of open fractures even exceeds 30% [9]. Traditionally, antibiotics used after surgery usually lead to the increment of drug-resistant bacteria, while comparatively the modification to the surface of implants for antimicrobial properties may be more effective. Specifically, recent studies have shown the feasibility of silver nanoparticles to prepare antibacterial coatings onto surfaces of medical metals, such as titanium and magnesium alloys [10], [11], [12], because of highly effective antibacterial and helpfully promoting regeneration of soft tissues [13]. However, the preparing procedures for obtaining Ag-contain coating have generally been complicated [10], [14], and few reports were focused on how to obtain Ag/LDH functional coating peculiarly by simple and facile methods. In this study, the coating of Ag-LDH will be prepared by hydrothermal method onto the surface of magnesium alloy. The microstructure and composition of the coating were systematically characterized and its in vitro degradation as well as antimicrobial properties were also investigated.
Section snippets
Experimental
The magnesium alloy of Mg-3Zn-0.5Zr-0.5Sr alloy (Φ8 × 3 mm) were finely polished, cleaned and dried. Then, the LDH and Ag-LDH coatings were prepared on magnesium alloy by a hydrothermal method, respectively. (For all the detailed experiments see the Supporting Information.)
Results and discussion
Fig. 1a shows the surface morphology of Ag-LDH and LDH coatings and the similitude of these samples morphologies are observed at both low and high magnification. Compared with the LDH coating, there are no apparent particles of nano Ag adhering to the LDH nanosheets as displayed in the Ag-LDH graph probably due to the smaller size of particles, but the presence of Ag element is detected through the corresponding EDS spectra in Fig. 1b. Meanwhile, the results in Fig. 1c show that the
Conclusion
In this study, hydrotalcite coating containing silver nanoparticles was successfully prepared on the Mg alloy surface by one-step hydrothermal reaction. The coating can inhibit the over-fast degradation of metal matrix and silver nanoparticles performed the better antibacterial function and activity against E. coli and S. aureus, which may provide the reference for facile preparation process and design of functional coating onto magnesium alloy.
CRediT authorship contribution statement
Yun Zhao: Conceptualization, Writing - original draft, Writing - review & editing, Visualization, Formal analysis. Yangping Chen: Methodology, Formal analysis, Resources. Wei Wang: Methodology, Formal analysis, Resources, Conceptualization. Zhiyu Zhou: Methodology, Investigation. Shuxin Shi: Methodology, Investigation. Wei Li: Conceptualization, Supervision. Minfang Chen: Conceptualization, Supervision, Project administration. Ze Li: Resources.
Declaration of Competing Interest
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Acknowledgements
This work was supported by National Nature Science Foundation of China (51801137, 51871166 and U1764254), and Tianjin Natural Science Foundation (117JCQNJC03100).
References (15)
- et al.
Mater. Sci. Eng. R
(2014) Surf. Coat. Technol.
(2014)- et al.
Int. J. Pharm.
(2014) - et al.
J. Hosp. Infect.
(2001) - et al.
Thin. Solid. Films
(2017) - et al.
Acta Biomater.
(2011) - et al.
J. Colloid Interface Sci.
(2018)
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