Multicomponent nanomaterials (MCNs) fabricated by rationally coupling distinct compositions in a controlled manner have shown improved chemical and physical properties when compared to any of the individual components. Such hybridization can not only efficiently retain the respective features of each ingredient but also provide more possibilities for controlling the surface states through as-generated synergistic effects. Great demands have been placed on the innovation of synthetic strategies for efficient fabrication with precisely controlled size, shape, composition and hybridization of nanostructures. Recently, redox interaction-engaged strategies (RIESs), which are performed by manipulating distinct precursors with suitable reduction and oxidation capabilities, have attracted tremendous interest of researchers, and great achievements have been made. During the synthesis process, no mass exchange occurs, which is completely different from a classic galvanic replacement reaction (GRR). Electron transmission and particle generation occur simultaneously, resulting in the formation of strongly coupled MCNs. Herein, we attempt to offer a systematic review of current achievements based on RIESs, beginning with a detailed summary of the operational process, sphere of applications and formation mechanism. Next, we focus on the improved performance of as-fabricated materials in catalytic reactions, and a comprehensive discussion of the structure–performance relationships is also presented. Last, we end with a brief conclusion and some prospects for future development trends in this promising research area.