Skip to main content
SpringerLink
Log in

Probiotic mediated NF-κB regulation for prospective management of type 2 diabetes

  • Review
  • Published:
Molecular Biology Reports Aims and scope Submit manuscript

Abstract

Diabetes and other lifestyle disorders have been recognized as the leading cause of morbidity and mortality globally. Nuclear factor kappa B (NF-κB) is a major factor involved in the early pathobiology of diabetes and studies reveal that hyperglycemic conditions in body leads to NF-κB mediated activation of several cytokines, chemokines and inflammatory molecules. NF-κB family comprises of certain DNA-binding protein factors that elicit the transcription of pro-inflammatory molecules. Various studies have identified NF-κB as a promising target for diabetic management. Probiotics have been proposed as bio-therapeutic agents for treatment of inflammatory disorders and many other chronic clinical stages. The precise mechanisms by which probiotics acts is yet to be fully understood, however research findings have indicated their role in NF-κB modulation. The current review highlights NF-κB as a bio-therapeutic target for probable management of type 2 diabetes through probiotic intervention.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

Abbreviations

NF-κB:

Nuclear factor kappa B

LAB:

Lactic acid bacteria

IDF:

International diabetes federation

References

  1. Cho N, Shaw JE, Karuranga S, Huang Y, da Rocha Fernandes JD, Ohlrogge AW, Malanda B (2018) IDF Diabetes Atlas: global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract 138:271–281

    CAS  PubMed  Google Scholar 

  2. Panwar H, Rashmi HM, Batish VK, Grover S, (2013) Probiotics as potential biotherapeutics in the management of type 2 diabetes–prospects and perspectives. Diabetes Metab Res Rev 29(2):103–112

    CAS  PubMed  Google Scholar 

  3. Salsali A, Nathan M (2006) A review of types 1 and 2 diabetes mellitus and their treatment with insulin. Am J Ther 13(4):349–361

    PubMed  Google Scholar 

  4. Ndisang JF, Vannacci A, Rastogi S (2017) Insulin resistance, type 1 and type 2 diabetes, and related complications. J Diabetes Res. https://doi.org/10.1155/2017/1478294

    Article  PubMed  PubMed Central  Google Scholar 

  5. Jayachandran M, Vinayagam R, Ambati RR, Xu B, Chung SSM, (2018) Guava leaf extract diminishes hyperglycemia and oxidative stress, prevents β-cell death, inhibits inflammation, and regulates NF-κB signaling pathway in STZ induced diabetic rats. BioMed Res Int. https://doi.org/10.1155/2018/4601649

    Article  PubMed  PubMed Central  Google Scholar 

  6. Lyssenko V, Laakso M (2013) Genetic screening for the risk of type 2 diabetes: worthless or valuable? Diabetes Care 36:S120–S126

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Baeyens L, Lemper M, Staels W, De Groef S, De Leu N, Heremans Y et al (2018) (Re) generating human beta cells: status, pitfalls, and perspectives. Physiol Rev 98(3):1143–1167

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Kulkarni RN (2004) The islet β-cell. Int J Biochem Cell Biol 36(3):365–371

    CAS  PubMed  Google Scholar 

  9. Cnop M, Welsh N, Jonas JC, Jörns A, Lenzen S, Eizirik DL, (2005) Mechanisms of pancreatic β-cell death in type 1 and type 2 diabetes: many differences, few similarities. Diabetes 54(suppl 2):S97–S107

    CAS  PubMed  Google Scholar 

  10. Nogueira TC, Paula FM, Villate O, Colli ML, Moura RF, Cunha DA et al (2013) GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim. PLoS Genet. https://doi.org/10.1371/journal.pgen.1003532

    Article  PubMed  PubMed Central  Google Scholar 

  11. Ardestani A, Paroni F, Azizi Z, Kaur S, Khobragade V, Yuan T et al (2014) MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes. Nat Med 20(4):385

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Coto E, Díaz-Corte C, Tranche S, Gómez J, Alonso B, Iglesias S et al (2018) Gene variants in the NF-KB pathway (NFKB1, NFKBIA, NFKBIZ) and their association with type 2 diabetes and impaired renal function. Hum Immunol 79(6):494–498

    CAS  PubMed  Google Scholar 

  13. Chen H, Zhou W, Ruan Y, Yang L, Xu N, Chen R et al (2018) Reversal of angiotensin ll-induced β-cell dedifferentiation via inhibition of NF-κb signaling. Mol Med 24(1):43

    PubMed  PubMed Central  Google Scholar 

  14. Guinane CM, Cotter PD (2013) Role of the gut microbiota in health and chronic gastrointestinal disease: understanding a hidden metabolic organ. Therap Adv Gastroenterol 6(4):295–308

    PubMed  PubMed Central  Google Scholar 

  15. Gomes AC, Bueno AA, de Souza RGM, Mota JF (2014) Gut microbiota, probiotics and diabetes. Nutr J 13(1):60

    PubMed  PubMed Central  Google Scholar 

  16. Holmes E, Li JV, Athanasiou T, Ashrafian H, Nicholson JK, (2011) Understanding the role of gut microbiome–host metabolic signal disruption in health and disease. Trends Microbiol 19(7):349–359

    CAS  PubMed  Google Scholar 

  17. Elshaghabee F, Rokana N, Panwar H, Heller KJ, Schrezenmeir J (2019) Probiotics for dietary management of non-alcoholic fatty liver disease. Environ Chem Lett. https://doi.org/10.1007/s10311-019-00896-8

    Article  Google Scholar 

  18. Thakur N, Rokana N, Panwar H (2016) Probiotics: selection criteria, safety and role in health and disease. J Innov Biol 3(1):259–270

    Google Scholar 

  19. Floch MH, Montrose DC (2005) Use of probiotics in humans: an analysis of the literature. Gastroenterol Clin 34(3):547–570

    Google Scholar 

  20. Panwar H, Calderwood D, Grant IR, Grover S, Green BD (2014) Lactobacillus strains isolated from infant faeces possess potent inhibitory activity against intestinal alpha- and beta-glucosidases suggesting anti-diabetic potential. Eur J Nutr 53(7):1465–1474

    CAS  PubMed  Google Scholar 

  21. Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, Morelli L, Canani RB, Flint HJ, Salminen S, Calder PC (2014) Expert consensus document: the International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol 11(8):506

    Google Scholar 

  22. Llewellyn A, Foey A (2017) Probiotic modulation of innate cell pathogen sensing and signalling events. Nutrients 9(10):1156

    PubMed Central  Google Scholar 

  23. Yan F, Polk DB (2010) Probiotics: progress toward novel therapies for intestinal diseases. Curr Opin Gastroenterol 26(2):95

    PubMed  PubMed Central  Google Scholar 

  24. Ghosh S, May MJ, Kopp EB (1998) NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Ann Rev Immunol 16(1):225–260

    CAS  Google Scholar 

  25. Pahl HL (1999) Activators and target genes of Rel/NF-κB transcription factors. Oncogene. https://doi.org/10.1038/sj.onc.1203239

    Article  PubMed  Google Scholar 

  26. Tang C, Zhu G (2019) Classic and novel signaling pathways involved cancer: targeting the NF-κB and Syk signaling pathways. Curr Stem Cell Res Ther 14(3):219–225

    CAS  PubMed  Google Scholar 

  27. Li Q, Verma IM (2002) NF-κB regulation in the immune system. Nat Rev Immunol 2(10):725

    CAS  PubMed  Google Scholar 

  28. Senftleben U, Karin M (2002) The Ikk/nf-κb pathway. Crit Care Med 30(1):S18–S26

    CAS  PubMed  Google Scholar 

  29. Silverman N, Maniatis T (2001) NF-κB signaling pathways in mammalian and insect innate immunity. Genes Dev 15(18):2321–2342

    CAS  PubMed  Google Scholar 

  30. Chen ZJ, Parent L, Maniatis T (1996) Site-specific phosphorylation of IκBα by a novel ubiquitination-dependent protein kinase activity. Cell 84(6):853–862

    CAS  PubMed  Google Scholar 

  31. Karin M, Ben-Neriah Y (2000) Phosphorylation meets ubiquitination: the control of NF-κB activity. Ann Rev Immunol 18(1):621–663

    CAS  Google Scholar 

  32. Zhou LZH, Johnson AP, Rando TA (2001) NFκB and AP-1 mediate transcriptional responses to oxidative stress in skeletal muscle cells. Free Radic Biol Med 31(11):1405–1416

    CAS  PubMed  Google Scholar 

  33. Serasanambati M, Chilakapati SR (2016) Function of nuclear factor kappa B (NF-kB) in human diseases-a review. South Indian J Biol Sci 2(4):368–387

    Google Scholar 

  34. Patel S, Santani D (2009) Role of NF-κB in the pathogenesis of diabetes and its associated complications. Pharmacol Rep 61(4):595–603

    CAS  PubMed  Google Scholar 

  35. Arakelyan A, Nersisyan L, Poghosyan D, Khondkaryan L, Hakobyan A, Löffler-Wirth H et al (2017) Autoimmunity and autoinflammation: a systems view on signaling pathway dysregulation profiles. PLoS ONE. https://doi.org/10.1371/journal.pone.0187572

    Article  PubMed  PubMed Central  Google Scholar 

  36. Eizirik DL, Mandrup-Poulsen T (2001) A choice of death–the signal-transduction of immune-mediated beta-cell apoptosis. Diabetologia 44(12):2115–2133

    CAS  PubMed  Google Scholar 

  37. Cardozo AK, Heimberg H, Heremans Y, Leeman R, Kutlu B, Kruhøffer M et al (2001) A comprehensive analysis of cytokine-induced and nuclear factor-κB-dependent genes in primary rat pancreatic β-cells. J Biol Chem 276(52):48879–48886

    CAS  PubMed  Google Scholar 

  38. Ding L, Fan L, Xu X, Fu J, Xue Y (2019) Identification of core genes and pathways in type 2 diabetes mellitus by bioinformatics analysis. Mol Med Rep 20:2597–2608

    CAS  PubMed  PubMed Central  Google Scholar 

  39. Li L, Pan Z, Yang S, Shan W, Yang Y (2018) Identification of key gene pathways and coexpression networks of islets in human type 2 diabetes. Diabetes Metab Syndr Obes 11:553–563

    CAS  PubMed  PubMed Central  Google Scholar 

  40. Luo B, Huang F, Liu Y, Liang Y, Wei Z, Ke H, Zeng Z, Huang W, He Y (2017) NLRP3 inflammasome as a molecular marker in diabetic cardiomyopathy. Front physiol 8:519

    PubMed  PubMed Central  Google Scholar 

  41. Zhang N, Valentine JM, Zhou Y, Li ME, Zhang Y, Bhattacharya A, Walsh ME, Fisher KE, Austad SN, Osmulski P, Gaczynska M, Shoelson SE, Remmen HV, Chen HI, Chen Y, Liang H, Musi N (2017) Sustained NFkB inhibition improves insulin sensitivity but is detrimental to muscle health. Aging Cell 16:847–858

    CAS  PubMed  PubMed Central  Google Scholar 

  42. Giannoukakis N, Mi Z, Rudert WA, Gambotto A, Trucco M, Robbins P (2000) Prevention of beta cell dysfunction and apoptosis activation in human islets by adenoviral gene transfer of the insulin-like growth factor I. Gene Thera 7(23):2015

    CAS  PubMed  Google Scholar 

  43. Ho E, Quan N, Tsai YH, Lai W, Bray TM (2001) Dietary zinc supplementation inhibits NFκB activation and protects against chemically induced diabetes in CD1 mice. Exp Biol Med 226(2):103–111

    CAS  Google Scholar 

  44. Mabley JG, Hasko G, Liaudet L, Soriano F, Southan GJ, Salzman AL et al (2002) NFkappaB1 (p50)-deficient mice are not susceptible to multiple low-dose streptozotocin-induced diabetes. J Endocrinol 173(3):457–464

    CAS  PubMed  Google Scholar 

  45. Lamhamedi-Cherradi SE, Zheng S, Hilliard BA, Xu L, Sun J, Alsheadat S et al (2003) Transcriptional regulation of type I diabetes by NF-κB. J Immunol 171(9):4886–4892

    CAS  PubMed  Google Scholar 

  46. Kumar D, Robertson S, Burns KD (2004) Evidence of apoptosis in human diabetic kidney. Mol Cell Biochem 259(1–2):67–70

    CAS  PubMed  Google Scholar 

  47. Song MY, Jeong GS, Kwon KB, Ka SO, Jang HY, Park JW et al (2010) Sulfuretin protects against cytokine-induced beta-cell damage and prevents streptozotocin-induced diabetes. Exp Mol Med 42(9):628–638

    CAS  PubMed  PubMed Central  Google Scholar 

  48. Collier JJ, Burke SJ, Eisenhauer ME, Lu D, Sapp RC, Frydman CJ et al (2011) Pancreatic β-cell death in response to pro-inflammatory cytokines is distinct from genuine apoptosis. PLoS ONE. https://doi.org/10.1371/journal.pone.0022485

    Article  PubMed  PubMed Central  Google Scholar 

  49. Burke SJ, Lu D, Sparer TE, Masi T, Goff MR, Karlstad MD et al (2013) NF-κB and STAT1 control CXCL1 and CXCL2 gene transcription. Am J Physiol Endocrinol Metab 306(2):E131–E149

    PubMed  PubMed Central  Google Scholar 

  50. Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, Long JM et al (2005) IKK-β links inflammation to obesity-induced insulin resistance. Nat Med 11(2):191

    CAS  PubMed  Google Scholar 

  51. Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J et al (2005) Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB. Nat Med 11(2):183

    CAS  PubMed  PubMed Central  Google Scholar 

  52. Hayden MS, Ghosh S (2014) Regulation of NF-kB by TNF family cytokines. Semin Immunol 26(3):253–266

    CAS  PubMed  PubMed Central  Google Scholar 

  53. Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM (1995) Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest 95(5):2409–2415

    CAS  PubMed  PubMed Central  Google Scholar 

  54. Gautam A, Gupta S, Mehndiratta M, Sharma M, Singh K, Kalra OP, Agarwal S, Gambhir JK (2017) Association of NFKB1 gene polymorphism (rs28362491) with levels of inflammatory biomarkers and susceptibility to diabetic nephropathy in Asian Indians. World J Diabetes 8(2):66

    PubMed  PubMed Central  Google Scholar 

  55. Romzova M, Hohenadel D, Kolostova K, Pinterova D, Fojtikova M, Ruzickova S, Dostal C, Bosak V, Rychlik I, Cerna M (2006) NFκB and its inhibitor IκB in relation to type 2 diabetes and its microvascular and atherosclerotic complications. Hum Immunol 67(9):706–713

    CAS  PubMed  Google Scholar 

  56. Cernea S, Dobreanu M (2013) Diabetes and beta cell function: from mechanisms to evaluation and clinical implications. Biochem Med 23(3):266–280

    CAS  Google Scholar 

  57. Norlin S, Ahlgren U, Edlund H (2005) Nuclear factor-κB activity in β-cells is required for glucose-stimulated insulin secretion. Diabetes 54(1):125–132

    CAS  PubMed  Google Scholar 

  58. Liuwantara D, Elliot M, Smith MW, Yam AO, Walters SN, Marino E, McShea A, Grey ST (2006) Nuclear factor- κB regulates β cell death. Diabetes 55(9):2491–2501

    CAS  PubMed  Google Scholar 

  59. Madsen KL (2012) Enhancement of epithelial barrier function by probiotics. J Epithel Biol Pharmacol 5(1):55–59

    CAS  Google Scholar 

  60. Hole AS, Grimmer S, Naterstad K, Jensen MR, Paur I, Johansen SG, Balstad TR, Blomhoff R, Sahlstrom S (2009) Activation and inhibition of nuclear factor kappa B activity by cereal extracts: role of dietary phenolic acids. J Agric Food Chem 57:9481–9488

    CAS  PubMed  Google Scholar 

  61. Wang T, Wu F, Jin Z, Zhai Z, Wang Y, Tu B, Yan W, Tang T (2014) Plumbagin inhibits LPS-induced inflammation through the inactivation of the nuclear factor-kappa B and mitogen activated protein kinase signaling pathways in RAW 264.7 cells. Food Chem Toxicol 64:177–183

    CAS  PubMed  Google Scholar 

  62. Huang CS, Fan YE, Lin CY, Hu ML (2007) Lycopene inhibits matrix metalloproteinase-9 expression and down-regulates the binding activity of nuclear factor-kappa B and stimulatory protein-1. J Nutr Biochem 18(7):449–456

    CAS  PubMed  Google Scholar 

  63. Nurmi A, Vartiainen N, Pihlaja R, Goldsteins G, Yrjanheikki J, Koistinaho J (2004) Pyrrolidine dithiocarbamate inhibits translocation of nuclear factor kappa-B in neurons and protects against brain ischaemia with a wide therapeutic time window. J Neurochem 91(3):755–765

    CAS  PubMed  Google Scholar 

  64. Tien MT, Girardin SE, Regnault B, Le Bourhis L, Dillies MA, Coppée JY et al (2006) Anti-inflammatory effect of Lactobacillus casei on Shigella-infected human intestinal epithelial cells. J Immunol 176(2):1228–1237

    CAS  PubMed  Google Scholar 

  65. Ma D, Forsythe P, Bienenstock J (2004) Live Lactobacillus reuteri is essential for the inhibitory effect on tumor necrosis factor alpha-induced interleukin-8 expression. Infect Immun 72(9):5308–5314

    CAS  PubMed  PubMed Central  Google Scholar 

  66. Zhang L, Li N, Caicedo R, Neu J (2005) Alive and dead Lactobacillus rhamnosus GG decrease tumor necrosis factor-α–induced interleukin-8 production in caco-2 cells. J Nutr 135(7):1752–1756

    CAS  PubMed  Google Scholar 

  67. O'hara AM, O'regan P, Fanning Á, O'mahony C, MacSharry J, Lyons A, et al (2006) Functional modulation of human intestinal epithelial cell responses by Bifidobacterium infantis and Lactobacillus salivarius. Immunology 118(2):202–215

    CAS  PubMed  PubMed Central  Google Scholar 

  68. Bu X, Lian X, Wang Y, Luo C, Tao S, Liao Y, Yang J, Chen A, Yang Y (2019) Dietary yeast culture modulates immune response related to TLR2-MyD88-NF-kβ signaling pathway, antioxidant capability and disease resistance against Aeromonas hydrophila for Ussuri catfish (Pseudobagrus ussuriensis). Fish Shellfish Immunol 84:711–718

    CAS  PubMed  Google Scholar 

  69. Sun KY, Xu DH, Xie C, Plummer S, Tang J, Yang XF et al (2017) Lactobacillus paracasei modulates LPS-induced inflammatory cytokine release by monocyte-macrophages via the up-regulation of negative regulators of NF-kappaB signaling in a TLR2-dependent manner. Cytokine 92:1–11

    CAS  PubMed  Google Scholar 

  70. Kaci G, Lakhdari O, Doré J, Ehrlich SD, Renault P, Blottière HM et al (2011) Inhibition of the NF-κB pathway in human intestinal epithelial cells by commensal Streptococcus salivarius. Appl Environ Microbiol 77(13):4681–4684

    CAS  PubMed  PubMed Central  Google Scholar 

  71. Cosseau C, Devine DA, Dullaghan E, Gardy JL, Chikatamarla A, Gellatly S et al (2008) The commensal Streptococcus salivarius K12 downregulates the innate immune responses of human epithelial cells and promotes host-microbe homeostasis. Infect Immun 76(9):4163–4175

    CAS  PubMed  PubMed Central  Google Scholar 

  72. Kim SW, Kim HM, Yang KM, Kim SA, Kim SK, An MJ et al (2010) Bifidobacterium lactis inhibits NF-κB in intestinal epithelial cells and prevents acute colitis and colitis-associated colon cancer in mice. Inflamm Bowel Dis 16(9):1514–1525

    PubMed  Google Scholar 

  73. Lakhdari O, Tap J, Béguet-Crespel F, Le Roux K, De Wouters T, Cultrone A et al (2011) Identification of NF-κB modulation capabilities within human intestinal commensal bacteria. BioMed Res Int. https://doi.org/10.1155/2011/282356

    Article  Google Scholar 

  74. Lin PW, Myers LE, Ray L, Song SC, Nasr TR, Berardinelli AJ et al (2009) Lactobacillus rhamnosus blocks inflammatory signaling in vivo via reactive oxygen species generation. Free Rad Biol Med 47(8):1205–1211

    CAS  PubMed  Google Scholar 

  75. Johnson-Henry KC, Nadjafi M, Avitzur Y, Mitchell DJ, Ngan BY, Galindo-Mata E et al (2005) Amelioration of the effects of Citrobacter rodentium infection in mice by pretreatment with probiotics. J Infect Dis 191(12):2106–2117

    PubMed  Google Scholar 

  76. Breyner NM, Michon C, de Sousa CS, Vilas Boas PB, Chain F, Azevedo VA, Langella P, Chatel JM (2017) Microbial anti-inflammatory molecule (MAM) from Faecalibacterium prausnitzii shows a protective effect on DNBS and DSS-induced colitis model in mice through inhibition of NF-κB pathway. Front Microbiol. https://doi.org/10.3389/fmicb.2017.00114

    Article  PubMed  PubMed Central  Google Scholar 

  77. Lee SK, Yang KM, Cheon JH, Kim TI, Kim WH (2012) Anti-inflammatory mechanism of Lactobacillus rhamnosus GG in lipopolysaccharide-stimulated HT-29 cell. Korean J Gastroenterol 60(2):86–93

    PubMed  Google Scholar 

  78. Wagner RD, Johnson SJ (2017) Probiotic bacteria prevent Salmonella–induced suppression of lymphoproliferation in mice by an immunomodulatory mechanism. BMC Microbiol 17(1):77

    PubMed  PubMed Central  Google Scholar 

  79. Kelly D, Campbell JI, King TP, Grant G, Jansson EA, Coutts AG et al (2004) Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelA. Nat Immunol 5:104–112

    CAS  PubMed  Google Scholar 

  80. Voltan S, Martines D, Elli M, Brun P, Longo S, Porzionato A et al (2008) Lactobacillus crispatus M247-derived H2O2 acts as a signal transducing molecule activating peroxisome proliferator activated receptor-γ in the intestinal mucosa. Gastroenterol 135(4):1216–1227

    CAS  Google Scholar 

  81. Volpe C, Villar-Delfino PH, Dos Anjos P, Nogueira-Machado JA (2018) Cellular death, reactive oxygen species (ROS) and diabetic complications. Cell Death Dis 9(2):119

    PubMed  PubMed Central  Google Scholar 

  82. Kumar A, Wu H, Collier-Hyams LS, Hansen JM, Li T, Yamoah K et al (2007) Commensal bacteria modulate cullin-dependent signaling via generation of reactive oxygen species. EMBO J 26(21):4457–4466

    CAS  PubMed  PubMed Central  Google Scholar 

  83. Donato KA, Gareau MG, Wang YJJ, Sherman PM (2010) Lactobacillus rhamnosus GG attenuates interferon-γ and tumour necrosis factor-α-induced barrier dysfunction and pro-inflammatory signalling. Microbiol 156(11):3288–3297

    CAS  Google Scholar 

  84. Liu Y, Fatheree NY, Mangalat N, Rhoads JM (2012) Lactobacillus reuteri strains reduce incidence and severity of experimental necrotizing enterocolitis via modulation of TLR4 and NFκB signaling in the intestine. Am J Physiol Heart Circ Physiol 302(6):G608–G617

    CAS  Google Scholar 

  85. Iyer C, Kosters A, Sethi G, Kunnumakkara AB, Aggarwal BB, Versalovic J, (2008) Probiotic Lactobacillus reuteri promotes TNF-induced apoptosis in human myeloid leukemia-derived cells by modulation of NF-κB and MAPK signalling. Cell Microbiol 10(7):1442–1452

    CAS  PubMed  Google Scholar 

  86. Menard S, Candalh C, Bambou JC, Terpend K, Cerf-Bensussan N, Heyman M (2004) Lactic acid bacteria secrete metabolites retaining anti-inflammatory properties after intestinal transport. Gut 53(6):821–828

    CAS  PubMed  PubMed Central  Google Scholar 

  87. Nishitani Y, Tanoue T, Yamada K, Ishida T, Yoshida M, Azuma T et al (2009) Lactococcus lactis subsp. cremoris FC alleviates symptoms of colitis induced by dextran sulfate sodium in mice. Int Immunopharmacol 9(12):1444–1451

    CAS  PubMed  Google Scholar 

  88. Versalovic J, Iyer C, Ping Lin Y, Huang Y, Dobrogosz W (2008) Commensal-derived probiotics as anti-inflammatory agents. Microbial Ecol Health Dis 20(2):86–93

    CAS  Google Scholar 

  89. Rahman MM, McFadden G (2011) Modulation of NF-κB signalling by microbial pathogens. Nat Rev Microbiol 9(4):291

    CAS  PubMed  PubMed Central  Google Scholar 

  90. Lee JM, Hwang KT, Jun WJ, Park CS, Lee MY (2008) Antiinflammatory effect of lactic acid bacteria: inhibition of cyclooxygenase-2 by suppressing nuclear factor-kappaB in Raw 264.7 macrophage cells. J Microbiol Biotechnol 18(10):1683–1688

    CAS  PubMed  Google Scholar 

  91. Petrof EO, Claud EC, Sun J, Abramova T, Guo Y, Waypa TS et al (2009) Bacteria-free solution derived from Lactobacillus plantarum inhibits multiple NF-kappaB pathways and inhibits proteasome function. Inflamm Bowel Dis 15(10):1537–1547

    PubMed  PubMed Central  Google Scholar 

  92. Ma X, Hua J, Li Z (2008) Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cells. J Hepatol 49:821–830

    CAS  PubMed  PubMed Central  Google Scholar 

  93. Jang SE, Hyam SR, Han MJ, Kim SY, Lee BG, Kim DH (2013) Lactobacillus brevis G-101 ameliorates colitis in mice by inhibiting NF-κB, MAPK and AKT pathways and by polarizing M1 macrophages to M2-like macrophages. J Appl Microbiol 115(3):888–896

    CAS  PubMed  Google Scholar 

  94. Eom JS, Song J, Choi HS (2015) Protective effects of a novel probiotic strain of Lactobacillus plantarum JSA22 from traditional fermented soybean food against infection by Salmonella enterica serovar Typhimurium. J Microbiol Biotechnol 25(4):479–491

    PubMed  Google Scholar 

  95. Sougioultzis S, Simeonidis S, Bhaskar KR, Chen X, Anton PM, Keates S et al (2006) Saccharomyces boulardii produces a soluble anti-inflammatory factor that inhibits NF-κB-mediated IL-8 gene expression. Biochem Biophys Res Commun 343(1):69–76

    CAS  PubMed  Google Scholar 

  96. Zhang M, Jin X, Yang YF (2019) β-Glucan from Saccharomyces cerevisiae induces SBD-1 production in ovine ruminal epithelial cells via the dectin-1–Syk–NF-κB signaling pathway. Cell Signal 53:304–315

    CAS  PubMed  Google Scholar 

  97. Le TK, Hosaka T, Nguyen TT, Kassu A, Dang TO, Tran HB, Pham TP, Tran QB, Le TH, Da Pham X (2015) Bifidobacterium species lower serum glucose, increase expressions of insulin signaling proteins, and improve adipokine profile in diabetic mice. Biomed Res 36(1):63–70

    CAS  PubMed  Google Scholar 

  98. O'Mahony C, Scully P, O'Mahony D, Murphy S, O'Brien F, Lyons A et al (2008) Commensal-induced regulatory T cells mediate protection against pathogen-stimulated NF-κB activation. PLoS Pathog. https://doi.org/10.1371/journal.ppat.1000112

    Article  PubMed  PubMed Central  Google Scholar 

  99. Khan S, Maremanda KP, Jena G. (2019) Butyrate, a short-chain fatty acid and histone deacetylases inhibitor: nutritional, physiological, and pharmacological aspects in diabetes. In: Handbook of nutrition, diet, and epigenetics Cham: Springer. 793–807

    Google Scholar 

  100. Kumar A, Wu H, Collier-Hyams LS, Kwon YM, Hanson JM, Neish AS, (2009) The bacterial fermentation product butyrate influences epithelial signaling via reactive oxygen species-mediated changes in cullin-1 neddylation. J Immunol 182(1):538–546

    CAS  PubMed  PubMed Central  Google Scholar 

  101. Toumi R, Soufli I, Rafa H, Belkhelfa M, Biad A, Touil-Boukoffa C (2014) Probiotic bacteria lactobacillus and bifidobacterium attenuate inflammation in dextran sulfate sodium-induced experimental colitis in mice. Int J Immunopathol Pharmacol 27(4):615–627

    CAS  PubMed  Google Scholar 

  102. Maciel FR, Punaro GR, Rodrigues AM, Bogsan CS, Rogero MM, Oliveira MN, Mouro MG, Higa EM (2016) Immunomodulation and nitric oxide restoration by a probiotic and its activity in gut and peritoneal macrophages in diabetic rats. Clin Nutr 35(5):1066–1072

    CAS  PubMed  Google Scholar 

  103. Bernini LJ, Simão ANC, de Souza CH, Alfieri DF, Segura LG, Costa GN, Dichi I (2018) Effect of Bifidobacterium lactis HN019 on inflammatory markers and oxidative stress in subjects with and without the metabolic syndrome. Br J Nutr 120(6):645–652

    CAS  PubMed  Google Scholar 

  104. Calcinaro F, Dionisi S, Marinaro M, Candeloro P, Bonato V, Marzotti S, Corneli RB, Ferretti E, Gulino A, Grasso F, De Simone C (2005) Oral probiotic administration induces interleukin-10 production and prevents spontaneous autoimmune diabetes in the non-obese diabetic mouse. Diabetologia 48(8):1565–1575

    CAS  PubMed  Google Scholar 

  105. Lavasani S, Dzhambazov B, Nouri M, Fåk F, Buske S, Molin G, Thorlacius H, Alenfall J, Jeppsson B, Weström B (2010) A novel probiotic mixture exerts a therapeutic effect on experimental autoimmune encephalomyelitis mediated by IL-10 producing regulatory T cells. PLoS ONE. https://doi.org/10.1371/journal.pone.0009009

    Article  PubMed  PubMed Central  Google Scholar 

  106. Garidou L, Pomie C, Klopp P, Waget A, Charpentier J, Aloulou M, Giry A, Serino M, Stenman L, Lahtinen S, Dray C, Iacovoni JS, Courtney M, Collet X, Amar J, Servant F, Lelouvier B, Valet P, Eberl G, Fazilleau N, Douin-Echinard V, Heymes C, Burcelin R (2015) The gut microbiota regulates intestinal CD4 T cells expressing RORγt and controls metabolic disease. Cell Metab 22(1):100–112

    CAS  PubMed  Google Scholar 

  107. Topol I, Kamyshny A (2013) Study of expression of TLR2, TLR4 and transckription factor NF-kB structures of galt of rats in the conditions of the chronic social stress and modulation of structure of intestinal microflora. Georgian Med News 12(225):115–120

    Google Scholar 

  108. Ganesan K, Chung SK, Vanamala J, Xu B (2018) Causal relationship between diet-induced gut microbiota changes and diabetes: a novel strategy to transplant Faecalibacterium prausnitzii in preventing diabetes. Int J Mol 19(12):3720

    Google Scholar 

  109. Bagarolli RA, Tobar N, Oliveira AG, Araújo TG, Carvalho BM, Rocha GZ, Vecina JF, Calisto K, Guadagnini D, Prada PO, Santos A (2017) Probiotics modulate gut microbiota and improve insulin sensitivity in DIO mice. J Nutr Biochem 50:16–25

    CAS  PubMed  Google Scholar 

  110. Trapecar M, Goropevsek A, Gorenjak M, Gradisnik L, Rupnik MS (2014) A co-culture model of the developing small intestine offers new insight in the early immunomodulation of enterocytes and macrophages by Lactobacillus spp. through STAT1 and NF-kB p65 Translocation. PLoS ONE. https://doi.org/10.1371/journal.pone.0086297

    Article  PubMed  PubMed Central  Google Scholar 

  111. Li Z, Yang S, Lin H, Huang J, Watkins PA, Moser AB et al (2003) Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatol 37(2):343–435

    CAS  Google Scholar 

  112. Reichold A, Brenner SA, Spruss A, Förster-Fromme K, Bergheim I, Bischoff SC (2014) Bifidobacterium adolescentis protects from the development of nonalcoholic steatohepatitis in a mouse model. J Nutr Biochem 25(2):118–125

    CAS  PubMed  Google Scholar 

Download references

Funding

This study did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Author information

Authors and Affiliations

  1. Department of Dairy Microbiology, College of Dairy Science and Technology, Guru Angad Dev Veterinary and Animal Sciences University (GADVASU), Ludhiana, Punjab, India

    Rabia Bhardwaj, Brij Pal Singh, Niharika Singh, Ravinder Kaur, Namita Rokana & Harsh Panwar

  2. Punjab Agricultural University, Ludhiana, Punjab, India

    Nitika Sandhu & Vishu Chaudhary

  3. National Centre for Cell Science (NCCS), Pune, Maharashtra, India

    Kumar Siddharth Singh

Authors
  1. Rabia Bhardwaj
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Brij Pal Singh
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Nitika Sandhu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Niharika Singh
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ravinder Kaur
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Namita Rokana
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Kumar Siddharth Singh
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Vishu Chaudhary
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Harsh Panwar
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Harsh Panwar.

Ethics declarations

Conflict of interest

All authors declare that they have no conflict of interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bhardwaj, R., Singh, B.P., Sandhu, N. et al. Probiotic mediated NF-κB regulation for prospective management of type 2 diabetes. Mol Biol Rep 47, 2301–2313 (2020). https://doi.org/10.1007/s11033-020-05254-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11033-020-05254-4

Keywords

Search

Navigation