Chem
Volume 6, Issue 1, 9 January 2020, Pages 10-11
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Deconstructive Functionalization of Ketones via an LMCT-Promoted C–C Cleavage

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In this issue of Chem, Zuo and coworkers report an exciting new strategy for the deconstructive functionalization of ketones. Through merging Lewis-acid-catalyzed nucleophilic 1,2-addition and ligand-to-metal charge transfer (LMCT)-promoted C–C cleavage, common strained and unstrained ketones are transformed into synthetically valuable scaffolds with high efficiency under mild conditions.

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