Issue 9, 2020
From the journal:

Chemical Communications

Stabilization of Grignard reagents by a pillar[5]arene host – Schlenk equilibria and Grignard reactions†

Lingyi Shen,a   Yanxia Zhao,a   Dihua Dai,b   Ying-Wei Yang, ORCID logo *b   Biao Wu ORCID logo ac  and  Xiao-Juan Yang ORCID logo *a  

* Corresponding authors

a Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi’an 710069, China
E-mail: yangxiaojuan@nwu.edu.cn

b International Joint Research Laboratory of Nano-Micro Architecture Chemistry (NMAC), College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, China
E-mail: ywyang@jlu.edu.cn

c State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China

Abstract

Grignard reagents (RMgX) are widely used in organic synthesis. However, these highly reactive compounds are supplied in inflammable solvents, which causes extra complexity in their transportation. Herein we report that Grignard reagents with linear alkyl chains can be entrapped and stabilized by the macrocyclic host pillar[5]arene while preserving their reactivity.

Graphical abstract: Stabilization of Grignard reagents by a pillar[5]arene host – Schlenk equilibria and Grignard reactions

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C9CC08728A
Article type
Communication
Submitted
08 Nov 2019
Accepted
19 Dec 2019
First published
07 Jan 2020

Chem. Commun., 2020,56, 1381-1384

Permissions

Request permissions

Stabilization of Grignard reagents by a pillar[5]arene host – Schlenk equilibria and Grignard reactions

L. Shen, Y. Zhao, D. Dai, Y. Yang, B. Wu and X. Yang, Chem. Commun., 2020, 56, 1381 DOI: 10.1039/C9CC08728A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements