Cell Metabolism
Volume 31, Issue 1, 7 January 2020, Pages 6-8
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Loss of TAZ Boosts PPARγ to Cope with Insulin Resistance

https://doi.org/10.1016/j.cmet.2019.12.006Get rights and content
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In this issue of Cell Metabolism, El Ouarrat et al. identify the Hippo signaling terminal effector TAZ as an endogenous negative regulator of PPARγ, a master transcriptional regulator of lipid metabolism and insulin sensitivity. Selective destruction of TAZ in adipocytes lowers inflammation and restores insulin sensitivity and glucose homeostasis.

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