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Recent advances and applications in LC-HRMS for food and plant natural products: a critical review

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Abstract

In the last decade, interest in food and plant natural products (FPNPs) has been growing due to their medical applications. Liquid chromatography-high-resolution mass spectrometry (LC-HRMS) is the key to obtaining pure natural products for structure elucidation as well as for development into therapeutic agents. In this review, we will provide a summary of recent advances and applications related to the analysis of the most common FPNPs in studied matrices, in particular, polyphenols, peptides, carotenoids, alkaloids, terpenoids and glucosinolates by LC-HRMS. This paper also reviews the critical revision of this topic covering the works published in the last 4 years (early 2016–mid 2019). In addition, it gives an overview of the current state of various screening strategies (e.g. targeted, suspected, untargeted or retrospective) with discussion on future directions and perspectives of this technique.

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Abbreviations

BAs:

Berberine alkaloids

DAD:

Diode array detector

FPNPs:

Food and plant natural products

GOTCABs:

Glucuronide oleanane-type triterpenoid carboxylic acid 3,28-bidesmosides

HCD:

High-energy collisional

HILIC:

Hydrophilic interaction liquid chromatography

HPLC:

High-performance liquid chromatography

HRMS:

High-resolution mass spectrometry

LC:

Liquid chromatography

LC-HRMS:

Liquid chromatography-high-resolution mass spectrometry

LC-LRMS:

Liquid chromatography-low-resolution mass spectrometry

MS:

Mass spectrometry

MS/MS:

Tandem mass spectrometry

Nano LC:

Nano-liquid chromatography

PAC:

Phellodendri Amurensis cortex

PAs:

Pyrrolizidine alkaloids

Q:

Quadrupole

RE:

Recovery

RP:

Reversed-phase

TAs:

Tropane alkaloids

TOF:

Time-of-flight

UHPLC:

Ultra-high-performance liquid chromatography

UPLC:

Ultra-performance liquid chromatography

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  1. Department of Food Engineering, Bingöl University, 12000, Bingöl, Turkey

    Cemil Aydoğan

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Aydoğan, C. Recent advances and applications in LC-HRMS for food and plant natural products: a critical review. Anal Bioanal Chem 412, 1973–1991 (2020). https://doi.org/10.1007/s00216-019-02328-6

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