Direct library preparation (DLP) for amplification-free single-cell whole-genome sequencing has been upgraded to a high-throughput, scalable platform for identification of clonal populations and their genomic features, integrating them with single-cell morphology.
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Change history
22 January 2020
A Correction to this paper has been published: https://doi.org/10.1038/s41592-020-0739-6
Research papers
Zahn, H. et al. Scalable whole-genome single-cell library preparation without preamplification. Nat. Methods 14, 167 (2017).
Laks, E. et al. Clonal decomposition and DNA replication states defined by scaled single-cell genome sequencing. Cell 179, 1207 (2019).
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Todorovic, V. Amplification-free single-cell whole-genome sequencing gets a makeover. Nat Methods 17, 27 (2020). https://doi.org/10.1038/s41592-019-0722-2
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DOI: https://doi.org/10.1038/s41592-019-0722-2
