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Kamonolol acetate from Ferula pseudalliacea as AChE inhibitor: in vitro and in silico studies

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Abstract

Alzheimer’s disease is one of the most common causes of dementia. Acetylcholinesterase has been considered as the main therapeutic target in the treatment of Alzheimer’s disease. Natural products are the richest source of lead compounds for the discovery and development of new drugs. In the present contribution, the hierarchical biology–oriented method was applied to discover the active gradients of F. pseudalliacea root as AChE inhibitors. The Kamonolol acetate was extracted and identified from the n-hexane extract of F. pseudalliacea root. The Kamonolol acetate inhibited the AChE with IC50: 63.9 μM. Molecular modeling studies showed that Kamonolol acetate interacted with CAS and PAS of AChE active site. Kinetics in accompany with molecular modeling studies demonstrated that Kamonolol acetate inhibited AChE in the mixed-type model. The results indicated that Kamonolol acetate could be considered as a valuable lead compound in the design of AChE inhibitors.

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Funding

The study was funded by the Vice-chancellor for Research and Technology, Hamadan University of Medical Sciences (No. 950117130).

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Authors and Affiliations

  1. Department of Pharmacognosy, School of Pharmacy, Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran

    Dara Dastan

  2. Department of Medicinal Chemistry, School of Pharmacy, Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran

    Samane Validi & Ahmad Ebadi

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  1. Dara Dastan
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  2. Samane Validi
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Correspondence to Ahmad Ebadi.

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Dastan, D., Validi, S. & Ebadi, A. Kamonolol acetate from Ferula pseudalliacea as AChE inhibitor: in vitro and in silico studies. Struct Chem 31, 965–973 (2020). https://doi.org/10.1007/s11224-019-01473-z

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  • DOI: https://doi.org/10.1007/s11224-019-01473-z

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