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Curse of the devil: molecular insights into the emergence of transmissible cancers in the Tasmanian devil (Sarcophilus harrisii)

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Abstract

The Tasmanian devil (Sarcophilus harrisii) is the only mammalian species known to be affected by multiple transmissible cancers. Devil facial tumours 1 and 2 (DFT1 and DFT2) are independent neoplastic cell lineages that produce large, disfiguring cancers known as devil facial tumour disease (DFTD). The long-term persistence of wild Tasmanian devils is threatened due to the ability of DFTD cells to propagate as contagious allografts and the high mortality rate of DFTD. Recent studies have demonstrated that both DFT1 and DFT2 cancers originated from founder cells of the Schwann cell lineage, an uncommon origin of malignant cancer in humans. This unprecedented finding has revealed a potential predisposition of Tasmanian devils to transmissible cancers of the Schwann cell lineage. In this review, we compare the molecular nature of human Schwann cells and nerve sheath tumours with DFT1 and DFT2 to gain insights into the emergence of transmissible cancers in the Tasmanian devil. We discuss a potential mechanism, whereby Schwann cell plasticity and frequent wounding in Tasmanian devils combine with an inherent cancer predisposition and low genetic diversity to give rise to transmissible Schwann cell cancers in devils on rare occasions.

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Acknowledgements

The authors wish to thank Narelle Phillips for immunohistochemistry, Karsten Goemann for scanning electron microscopy and Jocelyn Darby, Ruth Pye and Cesar Tovar for useful discussion. Research support was provided by the Australian Research Council (DP130100715, DE180100484, DP180100520) and the University of Tasmania Foundation through funds raised by the Save the Tasmanian Devil Appeal.

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  1. Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool Street, Hobart, TAS, 7000, Australia

    Amanda L. Patchett, Andrew S. Flies & Gregory M. Woods

  2. School of Medicine, University of Tasmania, Hobart, TAS, 7000, Australia

    A. Bruce Lyons

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Patchett, A.L., Flies, A.S., Lyons, A.B. et al. Curse of the devil: molecular insights into the emergence of transmissible cancers in the Tasmanian devil (Sarcophilus harrisii). Cell. Mol. Life Sci. 77, 2507–2525 (2020). https://doi.org/10.1007/s00018-019-03435-4

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