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Ancestry informative DIP loci for dissecting genetic structure and ancestry proportions of Qinghai Tibetan and Tibet Tibetan groups

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Abstract

Tibetans living in the Qing-Tibet plateau show unique genetic features since they are exposed to the high altitude environment. Accordingly, it is necessary for us to analyze genetic components of the Tibetan groups. Here, genetic structure and ancestry proportions of Tibet Tibetan and Qinghai Tibetan groups are dissected by using a previously published ancestral deletion/insertion polymorphisms (DIPs) panel. Genetic distributions of the analyzed DIPs in both Tibetan groups reveal that some DIPs show relatively balanced frequency distributions with the values ranging from 0.4 to 0.6, implying that these DIPs could be used as individual identification loci for forensic applications in both groups. Besides, the cumulative power of discrimination of the panel also reflects that the panel could serve as a valuable tool for forensic individual identifications in Tibet Tibetan and Qinghai Tibetan groups. Population genetic analyses including principal component analysis, DA genetic distances, phylogenetic tree, and genetic structure reveal that two studied Tibetan groups have closer genetic affiliations with East Asian populations. Genetic differentiation analyses of two Han populations, Xinjiang Uyghur and two Tibetan groups reveal that some DIP loci might be informative for differentiating Uyghurs from the other populations.

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Acknowledgements

This study is supported by the National Natural Science Foundation of China (81525015, 81471824), Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme (GDUPS, 2017).

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Author notes

  1. Xiao-Ye Jin and Chun-Mei Shen both have contributed equally to this study.

Authors and Affiliations

  1. Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an, China

    Xiao-Ye Jin, Chong Chen, Yu-Xin Guo, Wei Cui, Yi-Jie Wang, Wen-Qing Zhang, Ting-Ting Kong & Bo-Feng Zhu

  2. Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi’an Jiaotong University, Xi’an, China

    Xiao-Ye Jin, Chong Chen, Yu-Xin Guo, Wei Cui, Yi-Jie Wang, Wen-Qing Zhang, Ting-Ting Kong & Bo-Feng Zhu

  3. College of Forensic Medicine, Xi’an Jiaotong University Health Science Center, Xi’an, China

    Xiao-Ye Jin, Chong Chen, Yu-Xin Guo & Wei Cui

  4. Institute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi Normal University, Xi’an, China

    Chun-Mei Shen

  5. Department of Forensic Genetics, School of Forensic Medicine, Southern Medical University, Guangzhou, China

    Bo-Feng Zhu

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  1. Xiao-Ye Jin
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11033_2019_5202_MOESM1_ESM.png

Fig. S1. Population genetic structure analyses of different continental populations and two studied Tibetan populations at K = 2–7 (a) and the cross-validation errors of each K value (b). Supplementary material 1 (PNG 8517 kb)

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Jin, XY., Shen, CM., Chen, C. et al. Ancestry informative DIP loci for dissecting genetic structure and ancestry proportions of Qinghai Tibetan and Tibet Tibetan groups. Mol Biol Rep 47, 1079–1087 (2020). https://doi.org/10.1007/s11033-019-05202-x

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