Journal of Lipid Research
Research ArticlesEpoxyeicosatrienoic acid (EET)-stimulated angiogenesis is mediated by epoxy hydroxyeicosatrienoic acids (EHETs) formed from COX-2
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This work was supported by National Institutes of Health Grants RO1 ES0027010, P42 ES004699, R35 ES030443 (B.D.H.), T32 CA108459 (A.A.R.), and R01 HL082689 (A.G.P.); the 2016 American Association for Cancer Research Judah Folkman Fellowship for Angiogenesis Research (A.A.R.); and Natural Sciences and Engineering Research Council of Canada Grant RGPIN-2018-05330. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
The online version of this article (available at http://www.jlr.org) contains a supplement.
- ARA
arachidonic acid
- COX
cyclooxygenase
- CYP
cytochrome P450
- DHET
dihydroxyeicosatrienoic acid
- EET
epoxyeicosatrienoic acid
- EHET
epoxy hydroxyeicosatrienoic acid
- HAEC
human aortic endothelial cell
- PDBu
phorbol 12,13-dibutyrate
- sEH
soluble epoxide hydrolase
- t-AUCB
trans-4-(4-(3-adamantan-1-yl-ureido)-cyclohexloxyl)-benzoic acid
- THET
trihydroxyeicosatrienoic acid
- t-TUCB
trans-4-[4-(3-trifluoromethoxyphenyl-l-ureido)-cyclohexyloxy]benzoic acid
- VEGF
vascular endothelial growth factor
- VEGFR
VEGF receptor
Abbreviations: