Elsevier

Advanced Drug Delivery Reviews

Volumes 149–150, September–October 2019, Page 1
Advanced Drug Delivery Reviews

Sequential drug/gene delivery in tissue engineering & regenerative medicine

https://doi.org/10.1016/j.addr.2019.11.007Get rights and content

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    In sequential release systems, the carriers can be functionalized with two or more components that respond to multiple stimuli, in order to precisely release two or more -cargos at the target site at different times [61]. Recently, in a thematic issue of the journal of “Advanced Drug Delivery Reviews” Becker et al. and Chew et al. highlighted the aspects of sequential release in delivery systems [62,63]. Several studies have so far been conducted, investigating DGDS systems specifically designed to provide SR-based on pH changes, and the fact that different tissues of the body (especially tumors) have different pH ranges.

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