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Co-occurrence of pain syndromes

  • Neurology and Preclinical Neurological Studies - Review Article
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Abstract

Many pain conditions in patients tend to co-occur, influencing the clinical expressions of each other in various ways. This paper summarizes the main concurrent pain conditions by analyzing the major interactions observed. In particular, co-occurrence will be examined in: visceral pain (especially ischemic heart disease, irritable bowel syndrome, dysmenorrhea/endometriosis and urinary pain), fibromyalgia, musculoskeletal pain and headache. Two concurrent visceral pains from internal organs sharing at least part of their central sensory projection can give rise to viscero-visceral hyperalgesia, i.e., enhancement of typical pain symptoms from both districts. Visceral pain, headache and musculoskeletal pains (myofascial pain from trigger points, joint pain) can enhance pain and hyperalgesia from fibromyalgia. Myofascial pain from trigger points can perpetuate pain symptoms from visceral pain conditions and trigger migraine attacks when located in the referred pain area from an internal organ or in cervico-facial areas, respectively. The pathophysiology of these pain associations is complex and probably multifactorial; among the possible processes underlying the mutual influence of symptoms recorded in the associations is modulation of central sensitization phenomena by nociceptive inputs from one or the other condition. A strong message in these pain syndrome co-occurrence is that effective treatment of one of the conditions can also improve symptoms from the other, thus suggesting a systematic and thorough evaluation of the pain patient for a global effective management of his/her suffering.

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References

  • Aamodt AH, Stovner LJ, Hagen K, Zwart JA (2008) Comorbidity of headache and gastrointestinal complaints. Head HUNT Study. Cephalalgia 28:144–151

    CAS  PubMed  Google Scholar 

  • Adelborg K, Szépligeti SK, Holland-Bill L, Ehrenstein V, Horváth-Puhó E, Henderson VW, Sørensen HT (2018) Migraine and risk of cardiovascular diseases: Danish population based matched cohort study. BMJ 360:k96

    PubMed  PubMed Central  Google Scholar 

  • Affaitati G, Vecchiet F, Lerza R, De Laurentis S, Iezzi S, Festa F, Giamberardino MA (2001) Effects of topical diclofenac (DHEP plaster) on skin, subcutis and muscle pain thresholds in subjects without spontaneous pain. Drugs Exp Clin Res 27(2):69–76

    CAS  PubMed  Google Scholar 

  • Affaitati G, Giamberardino MA, Lerza R, Lapenna D, De Laurentis S, Vecchiet L (2002) Effects of tramadol on behavioural indicators of colic pain in a rat model of ureteral calculosis. Fundam Clin Pharmacol 16(1):23–30

    CAS  PubMed  Google Scholar 

  • Affaitati G, Fabrizio A, Savini A, Lerza R, Tafuri E, Costantini R, Lapenna D, Giamberardino MA (2009) A randomized, controlled study comparing a lidocaine patch, a placebo patch, and anesthetic injection for treatment of trigger points in patients with myofascial pain syndrome: evaluation of pain and somatic pain thresholds. Clin Ther 31(4):705–720

    CAS  PubMed  Google Scholar 

  • Affaitati G, Costantini R, Fabrizio A, Lapenna D, Tafuri E, Giamberardino MA (2011) Effects of treatment of peripheral pain generators in fibromyalgia patients. Eur J Pain 15:61–69

    PubMed  Google Scholar 

  • Affaitati G, Fabrizio A, Frangione V, Lanzarotti A, Lopopolo M, Tafuri E, Lapenna D, Giamberardino MA, Costantini R (2015) Effects of topical diclofenac plus heparin (DHEP + H plaster) on somatic pain sensitivity in healthy subjects with a latent algogenic condition of the lower limb. Pain Pract 15(1):58–67

    PubMed  Google Scholar 

  • Affaitati G, Martelletti P, Lopopolo M, Tana C, Massimini F, Cipollone F, Lapenna D, Giamberardino MA, Costantini R (2017) Use of nonsteroidal anti-inflammatory drugs for symptomatic treatment of episodic headache. Pain Pract 17(3):392–401

    PubMed  Google Scholar 

  • Affaitati G, Costantini R, Tana C, Lapenna D, Schiavone C, Cipollone F, Giamberardino MA (2018a) Effects of topical vs injection treatment of cervical myofascial trigger points on headache symptoms in migraine patients: a retrospective analysis. J Headache Pain 19(1):104

    PubMed  PubMed Central  Google Scholar 

  • Affaitati G, Giamberardino MA, Lapenna D, Costantini R (2018b) Diclofenac epolamine topical patch for the treatment of pain. J Biol Regul Homeost Agents 32(3):435–441

    CAS  PubMed  Google Scholar 

  • Alabousi A, Patlas MN, Mellnick VM, Chernyak V, Farshait N, Katz DS (2019) Renal colic imaging: myths, recent trends, and controversies. Can Assoc Radiol J 70(2):164–171

    PubMed  Google Scholar 

  • Aloisi AM, Affaitati G, Ceccarelli I, Fiorenzani P, Lerza R, Rossi C, Pace MC, Chiefari M, Aurilio C, Giamberardino MA (2010) Estradiol and testosterone differently affect visceral pain-related behavioural responses in male and female rats. Eur J Pain 14(6):602–607

    CAS  PubMed  Google Scholar 

  • Alonso-Blanco C, Fernández-de-las-Peñas C, Morales-Cabezas M, Zarco-Moreno P, Ge HY, Florez-García M (2011) Multiple active myofascial trigger points reproduce the overall spontaneous pain pattern in women with fibromyalgia and are related to widespread mechanical hypersensitivity. Clin J Pain 27(5):405–413

    PubMed  Google Scholar 

  • Altman G, Cain KC, Motzer S, Jarrett M, Burr R, Heitkemper M (2006) Increased symptoms in female IBS patients with dysmenorrhea and PMS. Gastroenterol Nurs 29:4–11

    PubMed  Google Scholar 

  • Alvarez DJ, Rockwell PG (2002) Trigger points: diagnosis and management. Am Fam Physician 65:653–660

    PubMed  Google Scholar 

  • American Headache Society (2019) The American Headache Society position statement on integrating new migraine treatments into clinical practice. Headache 59:1–18

    Google Scholar 

  • Ammons WS, Blair RW, Foreman RD (1984) Responses of primate T1–T5 spinothalamic neurons to gallbladder distension. Am J Physiol 247:995–1002

    Google Scholar 

  • Arendt-Nielsen L, Schipper KP, Dimcevski G, Sumikura H, Krarup AL, Giamberardino MA, Drewes AM (2008) Viscero-somatic reflexes in referred pain areas evoked by capsaicin stimulation of the human gut. Eur J Pain 12(5):544–551

    CAS  PubMed  Google Scholar 

  • Aziz Q, Giamberardino MA (2017) Visceral pain comorbidity in headache. In: Martelletti P, Giamberardino MA (eds) Comorbidities in headache disorders. Springer International Publishing, Switzerland, pp 65–84

    Google Scholar 

  • Aziz Q, Giamberardino MA, Barke A, Korwisi B, Baranowski AP, Wesselmann U, Rief W, Treede RD (2019) IASP Taskforce for the Classification of Chronic Pain The IASP classification of chronic pain for ICD-11: chronic secondary visceral pain. Pain 160(1):69–76

    PubMed  Google Scholar 

  • Bajaj P, Bajaj P, Madsen H, Arendt-Nielsen L (2003) Endometriosis is associated with central sensitization: a psychophysical controlled study. J Pain 4(7):372–380

    PubMed  Google Scholar 

  • Baranowski AP (2009) Chronic pelvic pain. Best Pract Res Clin Gastroenterol 23:593–610

    PubMed  Google Scholar 

  • Bartolini M, Giamberardino MA, Lisotto C, Martelletti P, Moscato D, Panascia B, Savi L, Pini LA, Sances G, Santoro P, Zanchin G, Omboni S, Ferrari MD, Brighina F, Fierro B (2011) A double-blind, randomized, multicenter, Italian study of frovatriptan versus almotriptan for the acute treatment of migraine. J Headache Pain 12(3):361–368

    CAS  PubMed  PubMed Central  Google Scholar 

  • Berkley KJ (2005) A life of pelvic pain. Physiol Behav 86:272–280

    CAS  PubMed  Google Scholar 

  • Berkley KJ, Cason A, Jacobs H, Bradshaw HB, Wood E (2001) Vaginal hyperalgesia in a rat model of endometriosis. Neurosci Lett 306:185–188

    CAS  PubMed  Google Scholar 

  • Bezov D, Ashina S, Jensen R, Bendtsen L (2011) Pain perception studies in tension-type headache. Headache 51:262–271

    PubMed  Google Scholar 

  • Bigal ME, Kurth T, Santanello N, Buse D, Golden W, Robbins M, Lipton RB (2010) Migraine and cardiovascular disease: a population-based study. Neurology 4(8):628–635

    Google Scholar 

  • Bonica JJ (ed) (1990) The management of pain, 2nd edn. Lea & Febiger, Philadephia

    Google Scholar 

  • Brinkert W, Dimcevski G, Arendt-Nielsen L, Drewes AM, Wilder-Smith OH (2007) Dysmenorrhoea is associated with hypersensitivity in the sigmoid colon and rectum. Pain 132:S46–S51

    PubMed  Google Scholar 

  • Brumovsky PR, Gebhart GF (2010) Visceral organ cross-sensitization: an integrated perspective. Auton Neurosci 153:106–115

    CAS  PubMed  Google Scholar 

  • Cabo-Meseguer A, Cerdá-Olmedo G, Trillo-Mata JL (2017) Fibromyalgia: prevalence, epidemiologic profiles and economic costs. Med Clin (Barc) 149:441–448

    Google Scholar 

  • Cakit BD, Taskin S, Nacir B, Unlu I, Genc H, Erdem HR (2010) Comorbidity of fibromyalgia and cervical myofascial pain. Clin Rheumatol 29:405–411

    PubMed  Google Scholar 

  • Caldarella MP, Giamberardino MA, Sacco F, Affaitati G, Milano A, Lerza R, Balatsinou C, Laterza F, Pierdomenico SD, Cuccurullo F, Neri M (2006) Sensitivity disturbances in patients with irritable bowel syndrome and fibromyalgia. Am J Gastroenterol 101(12):2782–2789

    PubMed  Google Scholar 

  • Cassisi G, Sarzi-Puttini P, Alciati A, Casale R, Bazzichi L, Carignola R, Gracely RH, Salaffi F, Marinangeli F, Torta R, Giamberardino MA, Buskila D, Spath M, Cazzola M, Di Franco M, Biasi G, Stisi S, Altomonte L, Arioli G, Leardini G, Gorla R, Marsico A, Ceccherelli F, Atzeni F, Network Italian Fibromyalgia (2008) Symptoms and signs in fibromyalgia syndrome. Reumatismo 60(Suppl 1):15–24

    PubMed  Google Scholar 

  • Castro Sánchez AM, García López H, Fernández Sánchez M, Pérez Mármol JM, Aguilar-Ferrándiz ME, Luque Suárez A, Matarán Peñarrocha GA (2009) Improvement in clinical outcomes after dry needling versus myofascial release on pain pressure thresholds, quality of life, fatigue, pain intensity, quality of sleep, anxiety, and depression in patients with fibromyalgia syndrome. Disabil Rehabil 41(19):2235–2246

    Google Scholar 

  • Centonze V, Polito BM, Cassiano MA, Doronzo F, Ricchetti G, Portincasa P, Bassi A, Albano O (1996) The dyspeptic syndrome in migraine: morphofunctional evaluation on 53 patients. Headache 36:442–445

    CAS  PubMed  Google Scholar 

  • Cervero F (2000) Visceral pain-central sensitization. Gut 47:56–57

    Google Scholar 

  • Cervero F, Laird JM (2004) Understanding the signaling and transmission of visceral nociceptive events. J Neurobiol 61:45–54

    CAS  PubMed  Google Scholar 

  • Chaban VV (2008) Visceral sensory neurons that innervate both uterus and colon express nociceptive TRPV1 and P2X3 receptors in rats. Ethn Dis 18:S220–S224

    Google Scholar 

  • Chaban V, Christensen A, Wakamatsu M, McDonald M, Rapkin A, McDonald J, Micevych P (2007) The same dorsal root ganglion neurons innervate uterus and colon in the rat. NeuroReport 18:209–212

    PubMed  Google Scholar 

  • Cho S-J, Sohn J-H, Bae JS, Chu MK (2017) Fibromyalgia Among Patients With Chronic Migraine and Chronic Tension-Type Headache: a Multicenter Prospective Cross-Sectional Study. Headache 57:1583–1592

    PubMed  Google Scholar 

  • Chung MK, Chung RP, Gordon D (2005) Interstitial cystitis and endometriosis in patients with chronic pelvic pain: the “Evil Twins” syndrome. JSLS 9(1):25–29

    PubMed  PubMed Central  Google Scholar 

  • Cole JA, Rothman KJ, Cabral HJ, Zhang Y, Farraye FA (2006) Migraine, fibromyalgia, and depression among people with IBS: a prevalence study. BMC Gastroenterol 6:26

    PubMed  PubMed Central  Google Scholar 

  • Colson NJ, Lea RA, Quinlan S, Griffiths LR (2006) No role for estrogen receptor 1 gene intron 1 Pvu II and exon 4 C325G polymorphisms in migraine susceptibility. BMC Med Genet 7:12

    PubMed  PubMed Central  Google Scholar 

  • Coppola G, Di Lorenzo C, Schoenen J, Pierelli F (2013) Habituation and sensitization in primary headaches. J Headache Pain 14:65

    PubMed  PubMed Central  Google Scholar 

  • Costantini R, Di Bartolomeo N, Francomano F, Angelucci D, Innocenti P (2005a) Epithelioid angiosarcoma of the gallbladder: case report. J Gastrointest Surg 9(6):822–825

    PubMed  Google Scholar 

  • Costantini R, Sardellone A, Marino C, Giamberardino MA, Innocenti P, Napolitano AM (2005b) Vacuum-assisted core biopsy (Mammotome) for the diagnosis of non-palpable breast lesions: four-year experience in an Italian center. Tumori 91(4):351–354

    PubMed  Google Scholar 

  • Costantini R, De Nicola P, Bianco F, Cotroneo AR, Iezzi R, Di Bartolomeo N, Innocenti P (2007) Tumor vs non-tumor origin of occult and obscure gastrointestinal bleeding requiring hospitalization. Tumori 93(5):461–466

    PubMed  Google Scholar 

  • Costantini R, Affaitati G, Fabrizio A, Giamberardino MA (2011) Controlling pain in the post-operative setting. Int J Clin Pharmacol Ther 49(2):116–127

    CAS  PubMed  Google Scholar 

  • Costantini R, Caldaralo F, Palmieri C, Napolitano L, Aceto L, Cellini C, Innocenti P (2012) Risk factors for conversion of laparoscopic cholecystectomy. Ann Ital Chir 83(3):245–252

    PubMed  Google Scholar 

  • Costantini R, Affaitati G, Massimini F, Tana C, Innocenti P, Giamberardino MA (2016) Laparoscopic Cholecystectomy for Gallbladder Calculosis in Fibromyalgia Patients: impact on Musculoskeletal Pain, Somatic Hyperalgesia and Central Sensitization. PLoS ONE 11(4):e0153408. https://doi.org/10.1371/journal.pone.0153408

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Costantini R, Affaitati G, Wesselmann U, Czakanski P, Giamberardino MA (2017) Visceral pain as a triggering factor for fibromyalgia symptoms in comorbid patients. Pain 158(10):1925–1937

    PubMed  Google Scholar 

  • Couppe C, Midttun A, Hilden J, Jorgensen U, Oxholm P, Fuglsang-Frederiksen A (2001) Spontaneous needle electromyographic activity in myofascial trigger points in the infraspinatus muscle: a blinded assessment. J Musculoske Pain 9:7–16

    Google Scholar 

  • Cummings M (2007) Regional myofascial pain: diagnosis and management. Best Pract Res Clin Rheumatol 21(2):367–387

    PubMed  Google Scholar 

  • Dahan A, van Velzen M, Niesters M (2014) Comorbidities and the complexities of chronic pain. Anesthesiology 121(4):675–677

    PubMed  Google Scholar 

  • de Tommaso M (2012) Prevalence, clinical features and potential therapies for fibromyalgia in primary headaches. Expert Rev Neurother 12:287–295

    PubMed  Google Scholar 

  • de Tommaso M, Sardaro M, Vecchio E, Serpino C, Stasi M, Ranieri M (2008) Central sensitisation phenomena in primary headaches: overview of a preventive therapeutic approach. CNS Neurol Disord: Drug Targets 7:524–535

    Google Scholar 

  • de Tommaso M, Sardaro M, Serpino C, Costantini F, Vecchio E, Prudenzano MP, Lamberti P, Livrea P (2009) Fibromyalgia comorbidity in primary headaches. Cephalalgia 29:453–464

    PubMed  Google Scholar 

  • de Tommaso M, Federici A, Loiacono A, Delussi M, Todarello O (2014) Personality profiles and coping styles in migraine patients with fibromyalgia comorbidity. Compr Psychiatry 55:80–86

    PubMed  Google Scholar 

  • Dimitrova AK, Ungaro RC, Lebwohl B, Lewis SK, Tennyson CA, Green MW, Babyatsky MW, Green PH (2013) Prevalence of migraine in patients with celiac disease and inflammatory bowel disease. Headache 53:344–355

    PubMed  Google Scholar 

  • Do TP, Heldarskard GF, Kolding LT, Hvedstrup J, Schytz HW (2018) Myofascial trigger points in migraine and tension-type headache. J Headache Pain 19(1):84

    PubMed  PubMed Central  Google Scholar 

  • Dommerholt J, Hooks T, Chou LW, Finnegan M (2019) A critical overview of the current myofascial pain literature - November 2018. J Bodyw Mov Ther 23(1):65–73

    PubMed  Google Scholar 

  • Drewes AM, Jennum P (1995) Epidemiology of myofascial pain, low back pain, morning stiffness and sleep-related complaints in the general population. J Musculoske Pain 3(1):121

    Google Scholar 

  • Duffield SJ, Ellis BM, Goodson N, Walker-Bone K, Conaghan PG, Margham T, Loftis T (2017) The contribution of musculoskeletal disorders in multimorbidity: implications for practice and policy. Best Pract Res Clin Rheumatol 31(2):129–144

    PubMed  Google Scholar 

  • Evans SF, Brooks TA, Esterman AJ, Hull ML, Rolan PE (2018) The comorbidities of dysmenorrhea: a clinical survey comparing symptom profile in women with and without endometriosis. J Pain Res 11:3181–3194

    PubMed  PubMed Central  Google Scholar 

  • Fan YH, Lin AT, Lu SH, Chuang YC, Chen KK (2014) Non-bladder conditions in female Taiwanese patients with interstitial cystitis/hypersensitive bladder syndrome. Int J Urol 21(8):805–809

    PubMed  Google Scholar 

  • Fariello JY, Moldwin RM (2015) Similarities between interstitial cystitis/bladder pain syndrome and vulvodynia: implications for patient management. Transl Androl Urol 4(6):643–652

    PubMed  PubMed Central  Google Scholar 

  • Fernández-de-Las-Peñas C, Dommerholt J (2018) International Consensus on Diagnostic Criteria and Clinical Considerations of Myofascial Trigger Points: a Delphi Study. Pain Med 19(1):142–150

    PubMed  Google Scholar 

  • Fernández-de-Las-Peñas C, Ge HY, Alonso-Blanco C, Gonzalez-Iglesias J, Arendt-Nielsen L (2010) Referred pain areas of active myofascial trigger points in head, neck and shoulder muscles, in chronic tension type headache. J Bodyw Mov Ther 14:391–396

    PubMed  Google Scholar 

  • Ferrero S, Pretta S, Bertoldi S, Anserini P, Remorgida V, Del Sette M, Gandolfo C, Ragni N (2004) Increased frequency of migraine among women with endometriosis. Hum Reprod 19(12):2927–2932

    CAS  PubMed  Google Scholar 

  • Festi D, Dormi A, Capodicasa S, Staniscia T, Attili AF, Loria P, Pazzi P, Gazzella G, Sama C, Roda E, Colecchia A (2008) Incidence of gallstone disease in Italy: results from a multicenter, population based Italian study (the MICOL project). World J Gastroenterol 14:5282–5289

    PubMed  PubMed Central  Google Scholar 

  • Filatova E, Latysheva N, Kurenkov A (2008) Evidence of persistent central sensitization in chronic headaches: a multi-method study. J Headache Pain 9:295–300

    PubMed  PubMed Central  Google Scholar 

  • Frøkjaer JB, Andersen SD, Gale J, Arendt-Nielsen L, Gregersen H, Drewes AM (2005) An experimental study of viscero-visceral hyperalgesia using an ultrasound-based multimodal sensory testing approach. Pain 119:191–200

    PubMed  Google Scholar 

  • García-Leiva JM, Hidalgo J, Rico-Villademoros F, Moreno V, Calandre EP (2007) Effectiveness of ropivacaine trigger points inactivation in the prophylactic management of patients with severe migraine. Pain Med 8(1):65–70

    PubMed  Google Scholar 

  • Ge HY, Nie H, Madeleine P, Danneskiold-Samsøe B, Graven-Nielsen T, Arendt-Nielsen L (2009) Contribution of the local and referred pain from active myofascial trigger points in fibromyalgia syndrome. Pain 147:233–240

    PubMed  Google Scholar 

  • Ge HY, Wang Y, Fernández-de-las-Peñas C, Graven-Nielsen T, Danneskiold-Samsøe B, Arendt-Nielsen L (2011) Reproduction of overall spontaneous pain pattern by manual stimulation of active myofascial trigger points in fibromyalgia patients. Arthritis Res Ther 13(2):R48

    PubMed  PubMed Central  Google Scholar 

  • Gebhart GF, Bielefeldt K (2016) Physiology of Visceral Pain. Compr Physiol 6(4):1609–1633

    CAS  PubMed  Google Scholar 

  • Georgiou I, Syrrou M, Bouba I, Dalkalitsis N, Paschopoulos M, Navrozoglou I, Lolis D (1999) Association of estrogen receptor gene polymorphisms with endometriosis. Fertil Steril 1:164–166

    Google Scholar 

  • Gerwin RD (1999) Myofascial pain syndromes from trigger points. Curr Rev Pain 3:153–159

    Google Scholar 

  • Gerwin RD (2001) Classification, epidemiology, and natural history of myofascial pain syndrome. Curr Pain Headache Rep 5:412–420

    CAS  PubMed  Google Scholar 

  • Gerwin RD (2016) Myofascial Trigger Point Pain Syndromes. Semin Neurol 36(5):469–473

    PubMed  Google Scholar 

  • Giamberardino MA (2008) Women and visceral pain: are the reproductive organs the main protagonists? Mini-review at the occasion of the “European Week Against Pain in Women 2007”. Eur J Pain 12(3):257–260

    PubMed  Google Scholar 

  • Giamberardino MA, Costantini R (2017) Challenging chronic migraine: targeting the CGRP receptor. Lancet Neurol 16(6):410–411

    PubMed  Google Scholar 

  • Giamberardino MA, Jensen T (eds) (2012) Pain comorbidities: understanding and treating the complex patient. IASP Press, Seattle, pp 1–518

    Google Scholar 

  • Giamberardino MA, Martelletti P (2015) Emerging drugs for migraine treatment. Expert Opin Emerg Drugs 20(1):137–147

    CAS  PubMed  Google Scholar 

  • Giamberardino MA, Vecchiet L (1995) Visceral pain, referred hyperalgesia and outcome: new concepts. Eur J Anaesthesiol Suppl 10:61–66

    CAS  PubMed  Google Scholar 

  • Giamberardino MA, de Bigontina P, Martegiani C, Vecchiet L (1994) Effects of extracorporeal shock-wave lithotripsy on referred hyperalgesia from renal/ureteral calculosis. Pain 56:77–83

    CAS  PubMed  Google Scholar 

  • Giamberardino MA, Dragani L, Valente R, Di Lisa F, Saggini R, Vecchiet L (1996) Effects of prolonged L-carnitine administration on delayed muscle pain and CK release after eccentric effort. Int J Sports Med 17(5):320–324

    CAS  PubMed  Google Scholar 

  • Giamberardino MA, Berkley KJ, Iezzi S, de Bigontina P, Vecchiet L (1997) Pain threshold variations in somatic wall tissues as a function of menstrual cycle, segmental site and tissue depth in non-dysmenorrheic women, dysmenorrheic women and men. Pain 71(2):187–197

    CAS  PubMed  Google Scholar 

  • Giamberardino MA, De Laurentis S, Affaitati G, Lerza R, Lapenna D, Vecchiet L (2001) Modulation of pain and hyperalgesia from the urinary tract by algogenic conditions of the reproductive organs in women. Neurosci Lett 304:61–64

    CAS  PubMed  Google Scholar 

  • Giamberardino MA, Berkley KJ, Affaitati G, Lerza R, Centurione L, Lapenna D, Vecchiet L (2002) Influence of endometriosis on pain behaviors and muscle hyperalgesia induced by a ureteral calculosis in female rats. Pain 95(3):247–257

    PubMed  Google Scholar 

  • Giamberardino MA, Affaitati G, Lerza R, Lapenna D, Costantini R, Vecchiet L (2005) Relationship between pain symptoms and referred sensory and trophic changes in patients with gallbladder pathology. Pain 114(1–2):239–249

    PubMed  Google Scholar 

  • Giamberardino MA, Affaitati G, Costantini R (2006) Chapter 24. Referred pain from internal organs. Handbook of Clinical Neurology 81:343–361

    PubMed  Google Scholar 

  • Giamberardino MA, Tafuri E, Savini A, Fabrizio A, Affaitati G, Lerza R, Di Ianni L, Lapenna D, Mezzetti A (2007) Contribution of myofascial trigger points to migraine symptoms. J Pain 8(11):869–878

    PubMed  Google Scholar 

  • Giamberardino MA, Affaitati G, Costantini R (2010a) Visceral referred pain. J Musculoske. Pain 18:403–410

    Google Scholar 

  • Giamberardino MA, Costantini R, Affaitati G, Fabrizio A, Lapenna D, Tafuri E, Mezzetti A (2010b) Viscero-visceral hyperalgesia: characterization in different clinical models. Pain 151(2):307–322

    PubMed  Google Scholar 

  • Giamberardino MA, Affaitati G, Fabrizio A, Costantini R (2011a) Effects of treatment of myofascial trigger points on the pain of fibromyalgia. Curr Pain Headache Rep 15(5):393–399

    PubMed  Google Scholar 

  • Giamberardino MA, Affaitati G, Fabrizio A, Costantini R (2011b) Myofascial pain syndromes and their evaluation. Best Pract Res Clin Rheumatol 25(2):185–198

    PubMed  Google Scholar 

  • Giamberardino MA, Affaitati G, Costantini R (2012) Concurrent visceral pain syndromes: the concept of viscero-visceral hyperalgesia. In: Giamberardino MA, Jensen TS (eds) Pain comorbidities: Understanding and treating the complex patient. IASP Press, Seattle, pp 309–330

    Google Scholar 

  • Giamberardino MA, Tana C, Costantini R (2014) Pain thresholds in women with chronic pelvic pain. Curr Opin Obstet Gynecol 26(4):253–259

    PubMed  Google Scholar 

  • Giamberardino MA, Affaitati G, Martelletti P, Tana C, Negro A, Lapenna D, Curto M, Schiavone C, Stellin L, Cipollone F, Costantini R (2015) Impact of migraine on fibromyalgia symptoms. J Headache Pain. 17:28

    PubMed  Google Scholar 

  • Giamberardino MA, Affaitati G, Curto M, Negro A, Costantini R, Martelletti P (2016) Anti-CGRP monoclonal antibodies in migraine: current perspectives. Intern Emerg Med 11(8):1045–1057

    PubMed  Google Scholar 

  • Giamberardino MA, Affaitati G, Costantini R, Cipollone F, Martelletti P (2017) Calcitonin gene-related peptide receptor as a novel target for the management of people with episodic migraine: current evidence and safety profile of erenumab. J Pain Res 10:2751–2760

    CAS  PubMed  PubMed Central  Google Scholar 

  • Graff-Radford SB (2004) Myofascial pain: diagnosis and management. Curr Pain Headache Rep 8:463–467

    PubMed  Google Scholar 

  • Grayston R, Czanner G, Elhadd K, Goebel A, Frank B, Üçeyler N, Malik RA, Alam U (2019) A systematic review and meta-analysis of the prevalence of small fiber pathology in fibromyalgia: implications for a new paradigm in fibromyalgia etiopathogenesis. Semin Arthritis Rheum 48:933–940

    PubMed  Google Scholar 

  • Graziano E, Hagemeier J, Weinstock-Guttman B, Ramasamy DP, Zivadinov R (2015) Increased contrast enhancing lesion activity in relapsing-remitting multiple sclerosis migraine patients. NeuroImage Clin 9:110–116

    PubMed  PubMed Central  Google Scholar 

  • Greenland P, Alpert JS, Beller GA, Benjamin EJ, Budoff MJ, Fayad ZA, Foster E, Hlatky MA, Hodgson JM, Kushner FG, Lauer MS, Shaw LJ, Smith SC Jr, Taylor AJ, Weintraub WS, Wenger NK, Jacobs AK, Smith SC Jr, Anderson JL, Albert N, Buller CE, Creager MA, Ettinger SM, Guyton RA, Halperin JL, Hochman JS, Kushner FG, Nishimura R, Ohman EM, Page RL et al (2010) 2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 56(25):e50–e103

    PubMed  Google Scholar 

  • Halder SLS, Locke GR III (2009) Epidemiology and social impact of visceral pain. In: Giamberardino MA (ed) Visceral pain:clinical, pathophysiological and therapeutic aspects. Oxford University Press, Oxford, pp 1–8

    Google Scholar 

  • Häuser W, Marschall U, Layer P, Grobe T (2019) The Prevalence, Comorbidity, Management and Costs of Irritable Bowel Syndrome. Dtsch Arztebl Int 116(27–28):463–470

    PubMed  PubMed Central  Google Scholar 

  • Headache Classification Committee of the International Headache Society (IHS) (2018) The international classification of headache disorders, 3rd edition. Cephalalgia 38:1–211

    Google Scholar 

  • Heidari F, Afshari M, Moosazadeh M (2017) Prevalence of fibromyalgia in general population and patients, a systematic review and meta-analysis. Rheumatol Int 37:1527–1539

    PubMed  Google Scholar 

  • Heitkemper MM, Jarrett ME (2008) Update on irritable bowel syndrome and gender differences. Nutr Clin Pract 23:275–283

    PubMed  Google Scholar 

  • Hejazi RA, McCallum RW (2011) Review article: cyclic vomiting syndrome in adults: rediscovering and redefining an old entity. Aliment Pharmacol Ther 4:263–273

    Google Scholar 

  • Hong C-Z, Chen Y-N, Twehous DA, Hong D (1996) Pressure threshold for referred pain by compression on the trigger point and adjacent areas. J Musculoske Pain 4:61–79

    Google Scholar 

  • Houghton LA, Lea R, Jackson N, Whorwell PJ (2002) The menstrual cycle affects rectal sensitivity in patients with irritable bowel syndrome but not healthy volunteers. Gut 50:471–474

    CAS  PubMed  PubMed Central  Google Scholar 

  • Iacovides S, Avidon I, Baker FC (2015) What we know about primary dysmenorrhea today: a critical review. Hum Reprod Update 21(6):762–778

    CAS  PubMed  Google Scholar 

  • Iuvone T, Affaitati G, De Filippis D, Lopopolo M, Grassia G, Lapenna D, Negro L, Costantini R, Vaia M, Cipollone F, Ialenti A, Giamberardino MA (2016) Ultramicronized palmitoylethanolamide reduces viscerovisceral hyperalgesia in a rat model of endometriosis plus ureteral calculosis: role of mast cells. Pain 157(1):80–91

    CAS  PubMed  Google Scholar 

  • Jarrell J, Giamberardino MA, Robert M, Nasr-Esfahani M (2011) Bedside testing for chronic pelvic pain: discriminating visceral from somatic pain. Pain Res Treat 2011:692102

    PubMed  PubMed Central  Google Scholar 

  • Jarrell J, Ross S, Robert M, Wood S, Tang S, Stephanson K, Giamberardino MA (2014) Prediction of postoperative pain after gynecologic laparoscopy for nonacute pelvic pain. Am J Obstet Gynecol 211(4):360.e1–360.e8

    Google Scholar 

  • Johnson CM, Makai GEH (2018) Fibromyalgia and Irritable Bowel Syndrome in Female Pelvic Pain. Semin Reprod Med 36(2):136–142

    PubMed  Google Scholar 

  • Kahriman A, Zhu S (2018) Migraine and Tension-Type Headache. Semin Neurol 38(6):608–618

    PubMed  Google Scholar 

  • Kato K, Sullivan PF, Evengard B, Pedersen NL (2006) Chronic widespread pain and its comorbidities: a population-based study. Arch Intern Med 166:1649–1654

    PubMed  Google Scholar 

  • Katz VL (2007) Endometriosis. In: Katz VL (ed) Comprehensive gynecology, 5th edn. Philadelphia, Mosby Elsevier, MD Consult

    Google Scholar 

  • Kaunisto MA, Kallela M, Hamalainen E, Kilpikari R, Havanka H, Harno H, Nissilä M, Säkö E, Ilmavirta M, Liukkonen J, Teirmaa H, Törnwall O, Jussila M, Terwilliger J, Färkkilä M, Kaprio J, Palotie A, Wessman M (2006) Testing of variants of the MTHFR and ESR1 genes in 1798 Finnish individuals fails to confirm the association with migraine with aura. Cephalalgia 26(12):1462–1472

    CAS  PubMed  Google Scholar 

  • Kim HJ (2016) Update on the pathology and diagnosis of interstitial cystitis/bladder pain syndrome: a review. Int Neurourol J 20(1):13–17

    PubMed  PubMed Central  Google Scholar 

  • Kim SH, Choi YM, Jun JK, Kim JG, Moon SY (2005) Estrogen receptor dinucleotide repeat polymorphism is associated with minimal or mild endometriosis. Fertil Steril 84(3):774–777

    CAS  PubMed  Google Scholar 

  • Kuan TS (2009) Current studies on myofascial pain syndrome. Curr Pain Headache Rep 13:365–369

    PubMed  Google Scholar 

  • Küçükşen S, Genç E, Yılmaz H, Sallı A, Gezer İA, Karahan AY, Salbaş E, Cingöz HT, Nas Ö, Uğurlu H (2013) The prevalence of fibromyalgia and its relation with headache characteristics in episodic migraine. Clin Rheumatol 32:983–990

    PubMed  Google Scholar 

  • Kurth T, Gaziano JM, Cook NR, Logroscino G, Diener HC, Buring JE (2006) Migraine and risk of cardiovascular disease in women. JAMA 296(3):283–291

    CAS  PubMed  Google Scholar 

  • Kurth T, Gaziano JM, Cook NR, Bubes V, Logroscino G, Diener HC, Buring JE (2007) Migraine and risk of cardiovascular disease in men. Arch Intern Med 167(8):795–801

    PubMed  Google Scholar 

  • Kurth T, Diener HC, Buring JE (2011) Migraine and cardiovascular disease in women and the role of aspirin: subgroup analyses in the Women’s Health Study. Cephalalgia 31(10):1106–1115

    PubMed  PubMed Central  Google Scholar 

  • Lackner JM, Ma C-X, Keefer LA, Brenner DM, Gudleski GD, Satchidanand N, Firth R, Sitrin MD, Katz L, Krasner SS, Ballou SK, Naliboff BD, Mayer EA (2013) Type, rather than number, of mental and physical comorbidities increases the severity of symptoms in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol 11(9):1147–1157

    PubMed  PubMed Central  Google Scholar 

  • Leo MM, Langlois BK, Pare JR, Mitchell P, Linden J, Nelson KP, Amanti C, Carmody KA (2017) Ultrasound vs. computed tomography for severity of hydronephrosis and its importance in renal colic. West J Emerg Med 18(4):559–668

    PubMed  PubMed Central  Google Scholar 

  • Li J, Micevych P, McDonald J, Rapkin A, Chaban V (2008) Inflammation in the uterus induces phosphorylated extracellular signal-regulated kinase and substance P immunoreactivity in dorsal root ganglia neurons innervating both uterus and colon in rats. J Neurosci Res 86:2746–2752

    CAS  PubMed  PubMed Central  Google Scholar 

  • Lichtenstein A, Tiosano S, Amital H (2018) The complexities of fibromyalgia and its comorbidities. Curr Opin Rheumatol 30(1):94–100

    PubMed  Google Scholar 

  • Loeser JD (2001) Bonica’s management of pain. Lippincott, Williams & Wilkins, Philadelphia

    Google Scholar 

  • Lopopolo M, Affaitati G, Fabrizio A, Massimini F, Lapenna D, Giamberardino MA, Costantini R (2014) Effects of tramadol on viscero-visceral hyperalgesia in a rat model of endometriosis plus ureteral calculosis. Fundam Clin Pharmacol 28(3):331–341

    CAS  PubMed  Google Scholar 

  • Lucas N, Macaskill P, Irwing L, Moran R, Bogduk N (2009) Reliability of physical examination for diagnosis of myofascial trigger points: a systematic review of the literature. Clin J Pain 25:80–89

    PubMed  Google Scholar 

  • Maggioni F, Palmieri A, Tropea M, Zanchin G (2008) Influence of physiologic hormonal modification and of hormonal treatment in a patient with a history of migraine with aura. J Headache Pain 9(2):129–131

    PubMed  PubMed Central  Google Scholar 

  • Majlesi J, Unalan H (2010) Effect of treatment on trigger points. Curr Pain Headache Rep 14:353–360

    PubMed  Google Scholar 

  • Malykhina AP (2007) Neural mechanisms of pelvic organ cross-sensitization. Neuroscience 149(3):660–672

    CAS  PubMed  Google Scholar 

  • Malykhina AP (2012) Experimental animal models of pain and non-pain comorbidities. In: Giamberardino MA, Jensen TS (eds) Pain comorbidities: Understanding and treating the complex patient. IASP Press, Seattle, pp 37–56

    Google Scholar 

  • Malykhina AP, Qin C, Greenwood-van Meerveld B, Foreman RD, Lupu F, Akbarali HI (2006) Hyperexcitability of convergent colon and bladder dorsal root ganglion neurons after colonic inflammation: mechanism for pelvic organ cross-talk. Neurogastroenterol Motil 18:936–948

    CAS  PubMed  Google Scholar 

  • Mannix LK (2008) Menstrual-related pain conditions: dysmenorrhea and migraine. J Womens Health (Larchmt) 17(5):879–891

    Google Scholar 

  • Marcus DA, Bhowmick A (2013) Fibromyalgia comorbidity in a community sample of adults with migraine. Clin Rheumatol 32:1553–1556

    PubMed  Google Scholar 

  • Marjoribanks J, Ayeleke RO, Farquhar C, Proctor M (2015) Nonsteroidal anti-inflammatory drugs for dysmenorrhoea. Cochrane Database Syst Rev 7:CD001751

    Google Scholar 

  • Marson L, Giamberardino MA, Costantini R, Czakanski P, Wesselmann U (2013) Animal models for the study of female sexual dysfunction. Sex Med Rev 1(2):108–122

    PubMed  PubMed Central  Google Scholar 

  • Matalliotakis IM, Cakmak H, Fragouli YG, Goumenou AG, Mahutte NG, Arici A (2008) Epidemiological characteristics in women with and without endometriosis in the Yale series. Arch Gynecol Obstet 277(5):389–393

    PubMed  Google Scholar 

  • Mense S, Simons DG, Russell IJ (2001) Muscle pain. Understanding its nature, diagnosis, and treatment. Lippincott, Williams & Wilkins, Philadelphia

    Google Scholar 

  • Merskey H (2012) Introduction. In: Giamberardino MA, Jensen TS (eds) Pain comorbidities. Understanding and treating the complex patient. IASP Press, Seattle, pp 1–17

    Google Scholar 

  • Meucci G, Radaelli F, Prada A, Bortoli A, Crotta S, Cerrato C, Minoli G (2005) Increased prevalence of migraine in patients with uninvestigated dyspepsia referred for open access upper gastrointestinal endoscopy. Endoscopy 37:622–625

    CAS  PubMed  Google Scholar 

  • Milligan ED, Watkins LR (2009) Pathological and protective roles of glia in chronic pain. Nat Rev Neurosci 10:23–36

    CAS  PubMed  PubMed Central  Google Scholar 

  • Möhrke J, Kropp P, Zettl UK (2013) Headaches in multiple sclerosis patients might imply an inflammatorial process. PLoS One 8:e69570

    PubMed  PubMed Central  Google Scholar 

  • Moisset X, Ouchchane L, Guy N, Bayle DJ, Dallel R, Clavelou P (2013) Migraine headaches and pain with neuropathic characteristics: comorbid conditions in patients with multiple sclerosis. Pain 154:2691–2699

    PubMed  Google Scholar 

  • Moisset X, Bommelaer G, Boube M, Ouchchane L, Goutte M, Dapoigny M, Dallel R, Guttmann A, Clavelou P, Buisson A (2017) Migraine prevalence in inflammatory bowel disease patients: a tertiary-care centre cross-sectional study. Eur J Pain 21(9):1550–1560

    CAS  PubMed  Google Scholar 

  • Money S (2017) Pathophysiology of trigger points in myofascial pain syndrome. J Pain Palliat Care Pharmacother 31(2):158–159

    PubMed  Google Scholar 

  • Morrison T, Dmitrieva N, Winnard KP, Berkley KJ (2006) Opposing viscerovisceral effects of surgically induced endometriosis and a control abdominal surgery on the rat bladder. Fertil Steril 86:1067–1073

    PubMed  Google Scholar 

  • Munakata J, Naliboff B, Harraf F, Kodner A, Lembo T, Chang L, Silverman DH, Mayer EA (1997) Repetitive sigmoid stimulation induces rectal hyperalgesia in patients with irritable bowel syndrome. Gastroenterology 112(1):55–63

    CAS  PubMed  Google Scholar 

  • Nicholas M, Vlaeyen JWS, Rief W, Barke A, Aziz Q, Benoliel R, Cohen M, Evers S, Giamberardino MA, Goebel A, Korwisi B, Perrot S, Svensson P, Wang SJ, Treede RD, IASP taskforce for the classification of chronic pain (2019) The IASP classification of chronic pain for ICD-11: chronic primary pain. Pain 160(1):28–37

    PubMed  Google Scholar 

  • Nierenburg Hdel C, Ailani J, Malloy M, Siavoshi S, Hu NN, Yusuf N (2015) Systematic review of preventive and acute treatment of menstrual migraine. Headache 55(8):1052–1071

    PubMed  Google Scholar 

  • Nunes FR, Ferreira JM, Bahamondes L (2014) Prevalence of fibromyalgia and quality of life in women with and without endometriosis. Gynecol Endocrinol 30:307–310

    PubMed  Google Scholar 

  • Nyholt DR, Gillespie NG, Merikangas KR, Treloar SA, Martin NG, Montgomery GW (2009) Common genetic influences underlie comorbidity of migraine and endometriosis. Genet Epidemiol 33(2):105–113

    PubMed  PubMed Central  Google Scholar 

  • Oaklander AL, Herzog ZD, Downs HM, Klein MM (2013) Objective evidence that small-fiber polyneuropathy underlies some illnesses currently labeled as fibromyalgia. Pain 154:2310–2316

    PubMed  Google Scholar 

  • Onder H, Hamamci M, Alpua M, Ulusoy EK (2019) Comorbid fibromyalgia in migraine patients: clinical significance and impact on daily life. Neurol Res 20:1–7

    Google Scholar 

  • Panerai AE, Vecchiet J, Panzeri P, Meroni P, Scarone S, Pizzigallo E, Giamberardino MA, Sacerdote P (2002) Peripheral blood mononuclear cell beta-endorphin concentration is decreased in chronic fatigue syndrome and fibromyalgia but not in depression: preliminary report. Clin J Pain 18(4):270–273

    PubMed  Google Scholar 

  • Park JW, Cho Y-S, Lee SY, Kim E-S, Cho H, Shin HE, Suh GI, Choi M-G (2013) Concomitant functional gastrointestinal symptoms influence psychological status in Korean migraine patients. Gut Liver 7(6):668–674

    PubMed  PubMed Central  Google Scholar 

  • Parthasarathy S, Sundar S, Mishra G (2019) Assessment of predisposing factors in myofascial pain syndrome and the analgesic effect of trigger point injections—a primary therapeutic interventional clinical trial. Indian J Anaesth 63(4):300–303

    CAS  PubMed  PubMed Central  Google Scholar 

  • Pezzone MA, Liang R, Fraser MO (2005) A model of neural cross-talk and irritation in the pelvis: implications for the overlap of chronic pelvic pain disorders. Gastroenterology 128:1953–1964

    PubMed  Google Scholar 

  • Podichetty VK, Mazanec DJ, Biscup RS (2003) Chronic non-malignant musculoskeletal pain in older adults: clinical issues and opioid intervention. Postgrad Med J 79:627–633

    CAS  PubMed  PubMed Central  Google Scholar 

  • Pomes LM, Guglielmetti M, Bertamino E, Simmaco M, Borro M, Martelletti P (2019) Optimising migraine treatment: from drug–drug interactions to personalized medicine. J Headache Pain 20(1):56

    PubMed  PubMed Central  Google Scholar 

  • Procacci P, Zoppi M, Maresca M (1986) Clinical approach to visceral sensation. In: Cervero F, Morrison JFB (eds) Visceral sensation. Progress in brain research. Elsevier, Amsterdam, pp 21–28

    Google Scholar 

  • Qin C, Malykhina AP, Thompson AM, Farber JP, Foreman RD (2010) Cross-organ sensitization of thoracic spinal neurons receiving noxious cardiac input in rats with gastroesophageal reflux. Am J Physiol Gastrointest Liver Physiol 298:934–942

    Google Scholar 

  • Reeves JL, Jaeger B, Graff-Radford A (1986) Reliability of the pressure algometer as a measure of myofascial trigger point sensitivity. Pain 24:313–321

    CAS  PubMed  Google Scholar 

  • Rist PM, Tzourio C, Kurth T (2011) Associations between lipid levels and migraine: cross-sectional analysis in the epidemiology of vascular ageing study. Cephalalgia 31(14):1459–1465

    PubMed  PubMed Central  Google Scholar 

  • Rodríguez-Osorio X, Sobrino T, Brea D, Martínez F, Leira CJ (2012) Endothelial progenitor cells: a new key for endothelial dysfunction in migraine. Neurology 79(5):474–479

    PubMed  Google Scholar 

  • Sacco S, Ricci S, Carolei A (2011) Tension-type headache and systemic medical disorders. Curr Pain Headache Rep 15:438–443

    PubMed  Google Scholar 

  • Sacco S, Ornello R, Ripa P, Tiseo C, Degan D, Pistoia F, Carolei A (2015) Migraine and risk of ischaemic heart disease: a systematic review and meta-analysis of observational studies. Eur J Neurol 22(6):1001–1011

    CAS  PubMed  Google Scholar 

  • Saggini R, Bellomo RG, Affaitati G, Lapenna D, Giamberardino MA (2007) Sensory and biomechanical characterization of two painful syndromes in the heel. J Pain 8(3):215–222

    PubMed  Google Scholar 

  • Sandner P, Tinel H, Affaitati G, Costantini R, Giamberardino MA (2015) Effects of PDE5 inhibitors and sGC stimulators in a rat model of artificial ureteral calculosis. PLoS One 10(10):e0141477

    PubMed  PubMed Central  Google Scholar 

  • Sasmaz Mİ, Kirpat V (2019) The relationship between the severity of pain and stone size, hydronephrosis and laboratory parameters in renal colic attack. Am J Emerg Med. https://doi.org/10.1016/j.ajem.2019.06.013. (Epub ahead of print)

    Article  PubMed  Google Scholar 

  • Schmidt-Hansen PT, Svensson P, Bendtsen L, Graven-Nielsen T, Bach FW (2007) Increased muscle pain sensitivity in patients with tension-type headache. Pain 129:113–121

    PubMed  Google Scholar 

  • Scott NA, Guo B, Barton PM, Gerwin RD (2009) Trigger point injections for chronic non-malignant musculoskeletal pain: a systematic review. Pain Med 10(1):54–69

    PubMed  Google Scholar 

  • Scripter C (2018) Headache: tension-type headache. FP Essent 473:17–20

    PubMed  Google Scholar 

  • Sengupta JN (2009) Visceral pain: the neurophysiological mechanism. Handb Exp Pharmacol 194:131–174

    Google Scholar 

  • Serra J, Collado A, Solà R, Antonelli F, Torres X, Salgueiro M, Quiles C, Bostock H (2014) Hyperexcitable C nociceptors in fibromyalgia. Ann Neurol 75:196–208

    CAS  PubMed  Google Scholar 

  • Shah JP, Phillips TM, Danoff JV, Gerber LH (2005) A in vivo microanalytical technique for measuring the local biochemical mileu of human skeletal muscle. J Appl Physiol 99:1977–1984

    CAS  PubMed  Google Scholar 

  • Shimomura T, Kowa H, Nakano T, Kitano A, Marukawa H, Urakami K, Takahashi K (1994) Platelet superoxide dismutase in migraine and tension-type headache. Cephalalgia 14(3):215–218

    CAS  PubMed  Google Scholar 

  • Simons DG (1990) Muscular pain syndromes. Adv Pain Res Ther 17:1–41

    Google Scholar 

  • Simons DG (2008) New views of myofascial trigger points: etiology and diagnosis. Arch Phys Med Rehabil 89(1):157–159

    PubMed  Google Scholar 

  • Simons DG, Travell JG, Simons LS (1999) Upper half of body. In: Travell & Simons’ myofascial pain and dysfunction. The trigger point manual, 2nd edn, vol 1. Williams & Wilkins, Baltimore, p 1038

  • Slade GD, Sanders AE, Bair E, Brownstein N, Dampier D, Knott C, Fillingim R, Maixner WO, Smith S, Greenspan J, Dubner R, Ohrbach R (2013) Preclinical episodes of orofacial pain symptoms and their association with health care behaviors in the OPPERA prospective cohort study. Pain 154:750–760

    PubMed  PubMed Central  Google Scholar 

  • Srbely JZ (2010) New trends in the treatment and management of myofascial pain syndrome. Curr Pain Headache Rep 14:346–352

    PubMed  Google Scholar 

  • Stanford EJ, Dell JR, Parsons CL (2007) The emerging presence of interstitial cystitis in gynecologic patients with chronic pelvic pain. Urology 69:53–59

    PubMed  Google Scholar 

  • Staud R (2007) Future perspectives: pathogenesis of chronic muscle pain. Best Pract Res Clin Rheumatol 21:581–596

    PubMed  Google Scholar 

  • Staud R, Nagel S, Robinson ME, Price DD (2009) Enhanced central pain processing of fibromyalgia patients is maintained by muscle afferent input: a randomized, double-blind, placebo-controlled study. Pain 145:96–104

    PubMed  PubMed Central  Google Scholar 

  • Steiner TJ, Stovner LJ, Vos T, Jensen R, Katsarava Z (2018) Migraine is first cause of disability in under 50 s: will health politicians now take notice? J Headache Pain 19(1):17

    PubMed  PubMed Central  Google Scholar 

  • Stickler GB (2005) Relationship between cyclic vomiting syndrome and migraine. Clin Pediatr (Phila) 44:505–508

    Google Scholar 

  • Stisi S, Cazzola M, Buskila D, Spath M, Giamberardino MA, Sarzi-Puttini P, Arioli G, Alciati A, Leardini G, Gorla R, Marsico A, Ceccherelli F, Bazzichi L, Carignola R, Gracely RH, Salaffi F, Marinangeli F, Torta R, Di Franco M, Biasi G, Cassisi G, Casale R, Altomonte L, Atzeni F (2008) Italian fibromyalgia network. Etiopathogenetic mechanisms of fibromyalgia syndrome. Reumatismo 60(Suppl 1):25–35

    PubMed  Google Scholar 

  • Stovner LJ, Ægidius K, Linde M (2011) Endometriosis and headache. Curr Pain Headache Rep 15:415–419

    PubMed  PubMed Central  Google Scholar 

  • Stratton P, Berkley KJ (2011) Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications. Hum Reprod Update 17(3):327–346

    PubMed  Google Scholar 

  • Tafuri E, Santovito D, de Nardis V, Marcantonio P, Paganelli C, Affaitati G, Bucci M, Mezzetti A, Giamberardino MA, Cipollone F (2015) MicroRNA profiling in migraine without aura: pilot study. Ann Med 47(6):468–473

    PubMed  Google Scholar 

  • Tana C, Tafuri E, Tana M, Martelletti P, Negro A, Affaitati G, Fabrizio A, Costantini R, Mezzetti A, Giamberardino MA (2013) New insights into the cardiovascular risk of migraine and the role of white matter hyperintensities: is gold all that glitters? J Headache Pain 14:9

    PubMed  PubMed Central  Google Scholar 

  • Tana C, Caulo M, Tafuri E, Di Vincenzo A, Tana M, De Angelis MV, Mezzetti A, Giamberardino MA (2014) Teaching neuroimages: a dangerous complication of spontaneous intracranial hypotension. Neurology 82(11):e94–e95

    PubMed  Google Scholar 

  • Tana C, Santilli F, Martelletti P, di Vincenzo A, Cipollone F, Davì G, Giamberardino MA (2015) Correlation between migraine severity and cholesterol levels. Pain Pract 15(7):662–670

    PubMed  Google Scholar 

  • Tana C, Giamberardino MA, Cipollone F (2017) microRNA profiling in atherosclerosis, diabetes, and migraine. Ann Med 49(2):93–105

    CAS  PubMed  Google Scholar 

  • Tchivileva IE, Ohrbach R, Fillingim RB, Greenspan JD, Maixner W, Slade GD (2017) Temporal change in headache and its contribution to the risk of developing first-onset temporomandibular disorder in the orofacial pain: prospective Evaluation and Risk Assessment (OPPERA) study. Pain 158:120–129

    PubMed  PubMed Central  Google Scholar 

  • Tervila L, Marttila P (1975) Headache as a symptom of endometriosis externa. Ann Chir Gynaecol Fenn 64(4):239–241

    CAS  PubMed  Google Scholar 

  • Tietjen GE, Bushnell CD, Herial NA, Utley C, White L, Hafeez F (2007) Endometriosis is associated with prevalence of comorbid conditions in migraine. Headache 47(7):1069–1078

    PubMed  Google Scholar 

  • Tough EA, White AR, Richards S, Campbell J (2007) Variability of criteria used to diagnose myofascial trigger point syndrome: evidence from a review of literature. Clin J Pain 23:276–286

    Google Scholar 

  • Treede RD, Rief W, Barke A, Aziz Q, Bennett MI, Benoliel R, Cohen M, Evers S, Finnerup NB, First MB, Giamberardino MA, Kaasa S, Korwisi B, Kosek E, Lavandʼhomme P, Nicholas M, Perrot S, Scholz J, Schug S, Smith BH, Svensson P, Vlaeyen JWS, Wang SJ (2019) Chronic pain as a symptom or a disease: the IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11). Pain 160(1):19–27

    PubMed  Google Scholar 

  • Treloar SA, Bell TA, Nagle CM, Purdie DM, Green AC (2010) Early menstrual characteristics associated with subsequent diagnosis of endometriosis. Am J Obstet Gynecol 202(6):534 (e1–6)

    PubMed  Google Scholar 

  • Vecchiet L, Giamberardino MA, Dragani L, Albe-Fessard D (1989) Pain from renal/ureteral calculosis: evaluation of sensory thresholds in the lumbar area. Pain 36:289–295

    CAS  PubMed  Google Scholar 

  • Vecchiet L, Giamberardino MA, Dragani L, de Bigontina P, Albe-Fessard D (1990) Latent myofascial trigger points: changes in muscular and subcutaneous pain thresholds at trigger point and target level. J Ma Med 5:151–154

    Google Scholar 

  • Vecchiet L, Giamberardino MA, Saggini R (1991) Myofascial pain syndromes: clinical and pathophysiological aspects. Clin J Pain 7(Suppl 1):S16–S22

    PubMed  Google Scholar 

  • Vecchiet L, Giamberardino MA, de Bigontina P (1992) Referred pain from viscera: when the symptom persists despite the extinction of the visceral focus. Adv Pain Res Ther 20:101–110

    Google Scholar 

  • Vecchiet L, Montanari G, Pizzigallo E, Iezzi S, de Bigontina P, Dragani L, Vecchiet J, Giamberardino MA (1996) Sensory characterization of somatic parietal tissues in chronic fatigue syndrome. Neurosci Lett 208:117–120

    CAS  PubMed  Google Scholar 

  • Vecchiet L, Pizzigallo E, Lezzi S, Affaitati G, Vecchiet J, Giamberardino MA (1998) Differentiation of sensitivity in different tissues and its clinical significance. J Musculoske Pain 6(1):33–45

    Google Scholar 

  • Vera-Portocarrero LP, Ossipov MH, King T, Porreca F (2008) Reversal of inflammatory and noninflammatory visceral pain by central or peripheral actions of sumatriptan. Gastroenterology 135(4):1369–1378

    CAS  PubMed  PubMed Central  Google Scholar 

  • Vij B, Whipple MO, Tepper SJ, Mohabbat AB, Stillman M, Vincent A (2015) Frequency of migraine headaches in patients with fibromyalgia. Headache 55:860–865

    PubMed  Google Scholar 

  • Wesselmann U, Czakanski PP, Affaitati G, Giamberardino MA (1998) Uterine inflammation as a noxious visceral stimulus: behavioral characterization in the rat. Neurosci Lett 246(2):73–76

    CAS  PubMed  Google Scholar 

  • Wilder-Smith CH, Robert-Yap J (2007) Abnormal endogenous pain modulation and somatic and visceral hypersensitivity in female patients with irritable bowel syndrome. World J Gastroenterol 13(27):3699–3704

    PubMed  PubMed Central  Google Scholar 

  • Winnard KP, Dmitrieva N, Berkley KJ (2006) Cross-organ interactions between reproductive, gastrointestinal, and urinary tracts: modulation by estrous stage and involvement of the hypogastric nerve. Am J Physiol Regul Integr Comp Physiol 291:R1592–R1601

    CAS  PubMed  Google Scholar 

  • Winsvold BS, Hagen K, Aamodt AH, Stovner LJ, Holmen J, Zwart JA (2011) Headache, migraine and cardiovascular risk factors: the HUNT study. Eur J Neurol 18(3):504–511

    CAS  PubMed  Google Scholar 

  • Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, Tugwell P, Campbell SM, Abeles M, Clark P, Fam AG, Farber SJ, Fiechtner JJ, Franklin CM, Gatter RA, Hamaty D, Lessard J, Lichtbroun AS, Masi AT, Mccain GA, Reynolds WJ, Romano TJ, Russell IJ, Sheon RP (1990) The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Report of the multicenter criteria committee. Arthritis Rheum 33:160–172

    CAS  PubMed  Google Scholar 

  • Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Katz RS, Mease P, Russell AS, Russell IJ, Winfield JB, Yunus MB (2010) The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res (Hoboken) 62:600–610

    Google Scholar 

  • Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Häuser W, Katz RL, Mease PJ, Russell AS, Russell IJ, Walitt B (2016) 2016 revisions to the 2010/2011 fibromyalgia diagnostic criteria. Semin Arthritis Rheum 46(3):319–329

    PubMed  Google Scholar 

  • Xu YM, Ge HY, Arendt-Nielsen L (2010) Sustained nociceptive mechanical stimulation of latent myofascial trigger point induces central sensitization in healthy subjects. J Pain 11:1348–1355

    PubMed  Google Scholar 

  • Zohsel K, Hohmeister J, Oelkers-Ax R, Flor H, Hermann C (2006) Quantitative sensory testing in children with migraine: preliminary evidence for enhanced sensitivity to painful stimuli especially in girls. Pain 123:10–18

    PubMed  Google Scholar 

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Correspondence to Maria Adele Giamberardino.

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Affaitati, G., Costantini, R., Tana, C. et al. Co-occurrence of pain syndromes. J Neural Transm 127, 625–646 (2020). https://doi.org/10.1007/s00702-019-02107-8

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