Elsevier

Journal of Clinical Lipidology

Volume 13, Issue 5, September–October 2019, Pages 854-855
Journal of Clinical Lipidology

Letter to the Editor
Screening for hyperglycerolemia by triglyceride assay in urine

https://doi.org/10.1016/j.jacl.2019.09.006Get rights and content

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Case presentation

A 34-year-old man with no toxic habits was referred to the lipid clinic for mild/moderate hypertriglyceridemia known since childhood. He maintains a healthy lifestyle and had received various lipid-lowering drugs (pitavastatin, fenofibrate, gemfibrozil, and omega-3 fatty acids), which failed to reduce his plasma triglycerides. His father has type 2 diabetes with mixed dyslipidemia responding to statin therapy; his mother is hypertensive with a normal lipid profile, and his 41-year-old sister

Discussion

One of the prominent clinical signs suggesting pseudohypertriglyceridemia is the lack of turbidity on visual inspection of the serum sample. Ordinarily, a true serum triglyceride level ≥ 300 mg/dL will lead to turbidity, obscuring newsprint held behind the specimen tube. When glycerolemia masquerading as hypertriglyceridemia is suspected, lipid testing using a blank for free glycerol is recommended.6 Furthermore, marked glyceroluria is observed on urine organic acid chromatography. Because not

Acknowledgments

Authors' contributions: All authors materially participated in the preparation of this article and have approved the final version.

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